IL-13–programmed airway tuft cells produce PGE(2), which promotes CFTR-dependent mucociliary function

Chronic type 2 (T2) inflammatory diseases of the respiratory tract are characterized by mucus overproduction and disordered mucociliary function, which are largely attributed to the effects of IL-13 on common epithelial cell types (mucus secretory and ciliated cells). The role of rare cells in airwa...

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Detalles Bibliográficos
Autores principales: Kotas, Maya E., Moore, Camille M., Gurrola, Jose G., Pletcher, Steven D., Goldberg, Andrew N., Alvarez, Raquel, Yamato, Sheyla, Bratcher, Preston E., Shaughnessy, Ciaran A., Zeitlin, Pamela L., Zhang, Irene H., Li, Yingchun, Montgomery, Michael T., Lee, Keehoon, Cope, Emily K., Locksley, Richard M., Seibold, Max A., Gordon, Erin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310525/
https://www.ncbi.nlm.nih.gov/pubmed/35608904
http://dx.doi.org/10.1172/jci.insight.159832

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