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Milademetan is a highly potent MDM2 inhibitor in Merkel cell carcinoma

Merkel cell carcinoma (MCC) is an aggressive neuroendocrine carcinoma of the skin with 2 etiologies. Merkel cell polyomavirus (MCPyV) integration is present in about 80% of all MCC. Virus-positive MCC (MCCP) tumors have few somatic mutations and usually express WT p53 (TP53). By contrast, virus-nega...

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Detalles Bibliográficos
Autores principales:	Ananthapadmanabhan, Varsha, Frost, Thomas C., Soroko, Kara M., Knott, Aine, Magliozzi, Brianna J., Gokhale, Prafulla C., Tirunagaru, Vijaya G., Doebele, Robert C., DeCaprio, James A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310528/ https://www.ncbi.nlm.nih.gov/pubmed/35801592 http://dx.doi.org/10.1172/jci.insight.160513

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