Nonhematopoietic IRAK1 drives arthritis via neutrophil chemoattractants

IL-1 receptor-activated kinase 1 (IRAK1) is involved in signal transduction downstream of many TLRs and the IL-1R. Its potential as a drug target for chronic inflammatory diseases is underappreciated. To study its functional role in joint inflammation, we generated a mouse model expressing a functio...

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Detalles Bibliográficos
Autores principales: Hoyler, Thomas, Bannert, Bettina, André, Cédric, Beck, Damian, Boulay, Thomas, Buffet, David, Caesar, Nadja, Calzascia, Thomas, Dawson, Janet, Kyburz, Diego, Hennze, Robert, Huppertz, Christine, Littlewood-Evans, Amanda, Loetscher, Pius, Mertz, Kirsten D., Niwa, Satoru, Robert, Gautier, Rush, James S., Ruzzante, Giulia, Sarret, Sophie, Stein, Thomas, Touil, Ismahane, Wieczorek, Grazyna, Zipfel, Geraldine, Hawtin, Stuart, Junt, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310529/
https://www.ncbi.nlm.nih.gov/pubmed/35801586
http://dx.doi.org/10.1172/jci.insight.149825

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310529/
https://www.ncbi.nlm.nih.gov/pubmed/35801586
http://dx.doi.org/10.1172/jci.insight.149825

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