Isolevuglandins disrupt PU.1-mediated C1q expression and promote autoimmunity and hypertension in systemic lupus erythematosus

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We describe a mechanism responsible for systemic lupus erythematosus (SLE). In humans with SLE and in 2 SLE murine models, there was marked enrichment of isolevuglandin-adducted proteins (isoLG adducts) in monocytes and dendritic cells. We found that antibodies formed against isoLG adducts in both S...

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Detalles Bibliográficos
Autores principales: Patrick, David M., de la Visitación, Néstor, Krishnan, Jaya, Chen, Wei, Ormseth, Michelle J., Stein, C. Michael, Davies, Sean S., Amarnath, Venkataraman, Crofford, Leslie J., Williams, Jonathan M., Zhao, Shilin, Smart, Charles D., Dikalov, Sergey, Dikalova, Anna, Xiao, Liang, Van Beusecum, Justin P., Ao, Mingfang, Fogo, Agnes B., Kirabo, Annet, Harrison, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310530/
https://www.ncbi.nlm.nih.gov/pubmed/35608913
http://dx.doi.org/10.1172/jci.insight.136678
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