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Undiagnosed diabetes: Prevalence and cardiovascular risk profile in a population‐based study of 52,856 individuals. The HUNT Study, Norway

AIMS: We investigated the current extent of undiagnosed diabetes and prediabetes and their associated cardiovascular risk profile in a population‐based study. METHODS: All residents aged ≥20 years in the Nord‐Trøndelag region, Norway, were invited to the HUNT4 Survey in 2017–2019, and 54% attended....

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Autores principales: Bjarkø, Vera Vik, Haug, Eirin B., Sørgjerd, Elin P., Stene, Lars C., Ruiz, Paz Lopez‐Doriga, Birkeland, Kåre I., Berg, Tore Julsrud, Gulseth, Hanne Løvdal, Iversen, Marjolein M., Langhammer, Arnulf, Åsvold, Bjørn Olav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310609/
https://www.ncbi.nlm.nih.gov/pubmed/35288977
http://dx.doi.org/10.1111/dme.14829
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author Bjarkø, Vera Vik
Haug, Eirin B.
Sørgjerd, Elin P.
Stene, Lars C.
Ruiz, Paz Lopez‐Doriga
Birkeland, Kåre I.
Berg, Tore Julsrud
Gulseth, Hanne Løvdal
Iversen, Marjolein M.
Langhammer, Arnulf
Åsvold, Bjørn Olav
author_facet Bjarkø, Vera Vik
Haug, Eirin B.
Sørgjerd, Elin P.
Stene, Lars C.
Ruiz, Paz Lopez‐Doriga
Birkeland, Kåre I.
Berg, Tore Julsrud
Gulseth, Hanne Løvdal
Iversen, Marjolein M.
Langhammer, Arnulf
Åsvold, Bjørn Olav
author_sort Bjarkø, Vera Vik
collection PubMed
description AIMS: We investigated the current extent of undiagnosed diabetes and prediabetes and their associated cardiovascular risk profile in a population‐based study. METHODS: All residents aged ≥20 years in the Nord‐Trøndelag region, Norway, were invited to the HUNT4 Survey in 2017–2019, and 54% attended. Diagnosed diabetes was self‐reported, and in those reporting no diabetes HbA1c was used to classify undiagnosed diabetes (≥48 mmol/mol [6.5%]) and prediabetes (39–47 mmol/mol [5.7%–6.4%]). We estimated the age‐ and sex‐standardized prevalence of these conditions and their age‐ and sex‐adjusted associations with other cardiovascular risk factors. RESULTS: Among 52,856 participants, the prevalence of diabetes was 6.0% (95% CI 5.8, 6.2), of which 11.1% were previously undiagnosed (95% CI 10.1, 12.2). The prevalence of prediabetes was 6.4% (95% CI 6.2, 6.6). Among participants with undiagnosed diabetes, 58% had HbA1c of 48–53 mmol/mol (6.5%–7.0%), and only 14% (i.e., 0.1% of the total study population) had HbA1c >64 mmol/mol (8.0%). Compared with normoglycaemic participants, those with undiagnosed diabetes or prediabetes had higher body mass index, waist circumference, systolic blood pressure, triglycerides and C‐reactive protein but lower low‐density lipoprotein cholesterol (all p < 0.001). Participants with undiagnosed diabetes had less favourable values for every measured risk factor compared with those with diagnosed diabetes. CONCLUSIONS: The low prevalence of undiagnosed diabetes suggests that the current case‐finding‐based diagnostic practice is well‐functioning. Few participants with undiagnosed diabetes had very high HbA1c levels indicating severe hyperglycaemia. Nonetheless, participants with undiagnosed diabetes had a poorer cardiovascular risk profile compared with participants with known or no diabetes.
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spelling pubmed-93106092022-07-29 Undiagnosed diabetes: Prevalence and cardiovascular risk profile in a population‐based study of 52,856 individuals. The HUNT Study, Norway Bjarkø, Vera Vik Haug, Eirin B. Sørgjerd, Elin P. Stene, Lars C. Ruiz, Paz Lopez‐Doriga Birkeland, Kåre I. Berg, Tore Julsrud Gulseth, Hanne Løvdal Iversen, Marjolein M. Langhammer, Arnulf Åsvold, Bjørn Olav Diabet Med Research: Epidemiology AIMS: We investigated the current extent of undiagnosed diabetes and prediabetes and their associated cardiovascular risk profile in a population‐based study. METHODS: All residents aged ≥20 years in the Nord‐Trøndelag region, Norway, were invited to the HUNT4 Survey in 2017–2019, and 54% attended. Diagnosed diabetes was self‐reported, and in those reporting no diabetes HbA1c was used to classify undiagnosed diabetes (≥48 mmol/mol [6.5%]) and prediabetes (39–47 mmol/mol [5.7%–6.4%]). We estimated the age‐ and sex‐standardized prevalence of these conditions and their age‐ and sex‐adjusted associations with other cardiovascular risk factors. RESULTS: Among 52,856 participants, the prevalence of diabetes was 6.0% (95% CI 5.8, 6.2), of which 11.1% were previously undiagnosed (95% CI 10.1, 12.2). The prevalence of prediabetes was 6.4% (95% CI 6.2, 6.6). Among participants with undiagnosed diabetes, 58% had HbA1c of 48–53 mmol/mol (6.5%–7.0%), and only 14% (i.e., 0.1% of the total study population) had HbA1c >64 mmol/mol (8.0%). Compared with normoglycaemic participants, those with undiagnosed diabetes or prediabetes had higher body mass index, waist circumference, systolic blood pressure, triglycerides and C‐reactive protein but lower low‐density lipoprotein cholesterol (all p < 0.001). Participants with undiagnosed diabetes had less favourable values for every measured risk factor compared with those with diagnosed diabetes. CONCLUSIONS: The low prevalence of undiagnosed diabetes suggests that the current case‐finding‐based diagnostic practice is well‐functioning. Few participants with undiagnosed diabetes had very high HbA1c levels indicating severe hyperglycaemia. Nonetheless, participants with undiagnosed diabetes had a poorer cardiovascular risk profile compared with participants with known or no diabetes. John Wiley and Sons Inc. 2022-03-21 2022-06 /pmc/articles/PMC9310609/ /pubmed/35288977 http://dx.doi.org/10.1111/dme.14829 Text en © 2022 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research: Epidemiology
Bjarkø, Vera Vik
Haug, Eirin B.
Sørgjerd, Elin P.
Stene, Lars C.
Ruiz, Paz Lopez‐Doriga
Birkeland, Kåre I.
Berg, Tore Julsrud
Gulseth, Hanne Løvdal
Iversen, Marjolein M.
Langhammer, Arnulf
Åsvold, Bjørn Olav
Undiagnosed diabetes: Prevalence and cardiovascular risk profile in a population‐based study of 52,856 individuals. The HUNT Study, Norway
title Undiagnosed diabetes: Prevalence and cardiovascular risk profile in a population‐based study of 52,856 individuals. The HUNT Study, Norway
title_full Undiagnosed diabetes: Prevalence and cardiovascular risk profile in a population‐based study of 52,856 individuals. The HUNT Study, Norway
title_fullStr Undiagnosed diabetes: Prevalence and cardiovascular risk profile in a population‐based study of 52,856 individuals. The HUNT Study, Norway
title_full_unstemmed Undiagnosed diabetes: Prevalence and cardiovascular risk profile in a population‐based study of 52,856 individuals. The HUNT Study, Norway
title_short Undiagnosed diabetes: Prevalence and cardiovascular risk profile in a population‐based study of 52,856 individuals. The HUNT Study, Norway
title_sort undiagnosed diabetes: prevalence and cardiovascular risk profile in a population‐based study of 52,856 individuals. the hunt study, norway
topic Research: Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310609/
https://www.ncbi.nlm.nih.gov/pubmed/35288977
http://dx.doi.org/10.1111/dme.14829
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