Translational Pharmacology of PRAX‐944, a Novel T‐Type Calcium Channel Blocker in Development for the Treatment of Essential Tremor

BACKGROUND: Essential tremor is the most common movement disorder with clear unmet need. Mounting evidence indicates tremor is caused by increased neuronal burst firing and oscillations in cerebello‐thalamo‐cortical circuitry and may be dependent on T‐type calcium channel activity. T‐type calcium ch...

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Detalles Bibliográficos
Autores principales: Scott, Liam, Puryear, Corey B., Belfort, Gabriel M., Raines, Shane, Hughes, Zoë A., Matthews, Lillian G., Ravina, Bernard, Wittmann, Marion
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Regular Issue Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310641/
https://www.ncbi.nlm.nih.gov/pubmed/35257414
http://dx.doi.org/10.1002/mds.28969

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