The Coordination of mTOR Signaling and Non-Coding RNA in Regulating Epileptic Neuroinflammation

Epilepsy accounts for a significant proportion of the burden of neurological disorders. Neuroinflammation acting as the inflammatory response to epileptic seizures is characterized by aberrant regulation of inflammatory cells and molecules, and has been regarded as a key process in epilepsy where mT...

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Autores principales: Zeng, Chudai, Hu, Jason, Chen, Fenghua, Huang, Tianxiang, Zhang, Longbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310657/
https://www.ncbi.nlm.nih.gov/pubmed/35898503
http://dx.doi.org/10.3389/fimmu.2022.924642
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author Zeng, Chudai
Hu, Jason
Chen, Fenghua
Huang, Tianxiang
Zhang, Longbo
author_facet Zeng, Chudai
Hu, Jason
Chen, Fenghua
Huang, Tianxiang
Zhang, Longbo
author_sort Zeng, Chudai
collection PubMed
description Epilepsy accounts for a significant proportion of the burden of neurological disorders. Neuroinflammation acting as the inflammatory response to epileptic seizures is characterized by aberrant regulation of inflammatory cells and molecules, and has been regarded as a key process in epilepsy where mTOR signaling serves as a pivotal modulator. Meanwhile, accumulating evidence has revealed that non-coding RNAs (ncRNAs) interfering with mTOR signaling are involved in neuroinflammation and therefore articipate in the development and progression of epilepsy. In this review, we highlight recent advances in the regulation of mTOR on neuroinflammatory cells and mediators, and feature the progresses of the interaction between ncRNAs and mTOR in epileptic neuroinflammation.
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spelling pubmed-93106572022-07-26 The Coordination of mTOR Signaling and Non-Coding RNA in Regulating Epileptic Neuroinflammation Zeng, Chudai Hu, Jason Chen, Fenghua Huang, Tianxiang Zhang, Longbo Front Immunol Immunology Epilepsy accounts for a significant proportion of the burden of neurological disorders. Neuroinflammation acting as the inflammatory response to epileptic seizures is characterized by aberrant regulation of inflammatory cells and molecules, and has been regarded as a key process in epilepsy where mTOR signaling serves as a pivotal modulator. Meanwhile, accumulating evidence has revealed that non-coding RNAs (ncRNAs) interfering with mTOR signaling are involved in neuroinflammation and therefore articipate in the development and progression of epilepsy. In this review, we highlight recent advances in the regulation of mTOR on neuroinflammatory cells and mediators, and feature the progresses of the interaction between ncRNAs and mTOR in epileptic neuroinflammation. Frontiers Media S.A. 2022-07-11 /pmc/articles/PMC9310657/ /pubmed/35898503 http://dx.doi.org/10.3389/fimmu.2022.924642 Text en Copyright © 2022 Zeng, Hu, Chen, Huang and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zeng, Chudai
Hu, Jason
Chen, Fenghua
Huang, Tianxiang
Zhang, Longbo
The Coordination of mTOR Signaling and Non-Coding RNA in Regulating Epileptic Neuroinflammation
title The Coordination of mTOR Signaling and Non-Coding RNA in Regulating Epileptic Neuroinflammation
title_full The Coordination of mTOR Signaling and Non-Coding RNA in Regulating Epileptic Neuroinflammation
title_fullStr The Coordination of mTOR Signaling and Non-Coding RNA in Regulating Epileptic Neuroinflammation
title_full_unstemmed The Coordination of mTOR Signaling and Non-Coding RNA in Regulating Epileptic Neuroinflammation
title_short The Coordination of mTOR Signaling and Non-Coding RNA in Regulating Epileptic Neuroinflammation
title_sort coordination of mtor signaling and non-coding rna in regulating epileptic neuroinflammation
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310657/
https://www.ncbi.nlm.nih.gov/pubmed/35898503
http://dx.doi.org/10.3389/fimmu.2022.924642
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