A Selective Adenylyl Cyclase 1 Inhibitor Relieves Pain Without Causing Tolerance

Among the ten different adenylyl cyclase isoforms, studies with knockout animals indicate that inhibition of AC1 can relieve pain and reduce behaviors linked to opioid dependence. We previously identified ST034307 as a selective inhibitor of AC1. The development of an AC1-selective inhibitor now pro...

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Detalles Bibliográficos
Autores principales: Giacoletti, Gianna, Price, Tatum, Hoelz, Lucas V. B., Shremo Msdi, Abdulwhab, Cossin, Samantha, Vazquez-Falto, Katerina, Amorim Fernandes, Tácio V., Santos de Pontes, Vinícius, Wang, Hongbing, Boechat, Nubia, Nornoo, Adwoa, Brust, Tarsis F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310748/
https://www.ncbi.nlm.nih.gov/pubmed/35899113
http://dx.doi.org/10.3389/fphar.2022.935588

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310748/
https://www.ncbi.nlm.nih.gov/pubmed/35899113
http://dx.doi.org/10.3389/fphar.2022.935588

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