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VhH anti‐thrombomodulin clone 1 inhibits TAFI activation and enhances fibrinolysis in human whole blood under flow

BACKGROUND: Thrombomodulin on endothelial cells can form a complex with thrombin. This complex has both anticoagulant properties, by activating protein C, and clot‐protective properties, by activating thrombin‐activatable fibrinolysis inhibitor (TAFI). Activated TAFI (TAFIa) inhibits plasmin‐mediate...

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Detalles Bibliográficos
Autores principales:	van Moorsel, Marc V. A., Poolen, Geke C., Koekman, Cornelis A., Verhoef, Sandra, de Maat, Steven, Barendrecht, Arjan, van Kleef, Nadine D., Meijers, Joost C. M., Schiffelers, Raymond M., Maas, Coen, Urbanus, Rolf T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	FIBRINOLYSIS
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311061/ https://www.ncbi.nlm.nih.gov/pubmed/35170225 http://dx.doi.org/10.1111/jth.15674

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