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Time trends in psychotropic drug prescriptions in Dutch nursing home residents with dementia between 2003 and 2018

OBJECTIVE: Several European studies investigated the trends in psychotropic drug prescriptions (PDPs) among nursing home (NH) residents and reported a decline in antipsychotics prescriptions. Since the Dutch long‐term care system differs from other European systems (e.g. higher threshold for NH admi...

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Autores principales: Du, Jiamin, Janus, Sarah, Voorthuis, Brenda, van Manen, Jeannette, Achterberg, Wilco, Smalbrugge, Martin, Zwijsen, Sandra, Gerritsen, Debby, Koopmans, Raymond, Zuidema, Sytse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311063/
https://www.ncbi.nlm.nih.gov/pubmed/35297551
http://dx.doi.org/10.1002/gps.5697
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author Du, Jiamin
Janus, Sarah
Voorthuis, Brenda
van Manen, Jeannette
Achterberg, Wilco
Smalbrugge, Martin
Zwijsen, Sandra
Gerritsen, Debby
Koopmans, Raymond
Zuidema, Sytse
author_facet Du, Jiamin
Janus, Sarah
Voorthuis, Brenda
van Manen, Jeannette
Achterberg, Wilco
Smalbrugge, Martin
Zwijsen, Sandra
Gerritsen, Debby
Koopmans, Raymond
Zuidema, Sytse
author_sort Du, Jiamin
collection PubMed
description OBJECTIVE: Several European studies investigated the trends in psychotropic drug prescriptions (PDPs) among nursing home (NH) residents and reported a decline in antipsychotics prescriptions. Since the Dutch long‐term care system differs from other European systems (e.g. higher threshold for NH admission and trained elderly care physicians), this study explores the trends in PDPs in Dutch NH residents with dementia. METHODS: The study used data from nine studies, comprising two cross‐sectional studies, one cohort study, and six cluster‐randomized controlled trials, collected in Dutch NHs between 2003 and 2018. With multilevel logistic regression analysis, NHs as a random effect, we estimated the trends in PDPs overall and for five specific psychotropic drug groups (antipsychotics, antidepressants, anxiolytics, hypnotics, and anti‐dementia drugs), adjusting for confounders: age, gender, severity of dementia, severity of neuropsychiatric symptoms, and length of stay in NHs. RESULTS: The absolute prescription rate of antipsychotics was 37.5% in 2003 and decreased (OR = 0.947, 95% CI [0.926, 0.970]) every year. The absolute prescription rate of anti‐dementia drugs was 0.8% in 2003 and increased (OR = 1.162, 95% CI [1.105, 1.223]) per year. The absolute rate of overall PDPs declined from 62.7% in 2003 to 40.4% in 2018. CONCLUSIONS: Among Dutch NH residents with dementia, the odds of antipsychotics prescriptions decreased by 5.3% per year while the odds of anti‐dementia drug prescriptions increased by 16.2%. There were no distinct trends in antidepressants, anxiolytics, and hypnotics prescriptions. However, overall PDPs were still high. The PDPs in NH residents remain an issue of concern.
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spelling pubmed-93110632022-07-29 Time trends in psychotropic drug prescriptions in Dutch nursing home residents with dementia between 2003 and 2018 Du, Jiamin Janus, Sarah Voorthuis, Brenda van Manen, Jeannette Achterberg, Wilco Smalbrugge, Martin Zwijsen, Sandra Gerritsen, Debby Koopmans, Raymond Zuidema, Sytse Int J Geriatr Psychiatry Research Article OBJECTIVE: Several European studies investigated the trends in psychotropic drug prescriptions (PDPs) among nursing home (NH) residents and reported a decline in antipsychotics prescriptions. Since the Dutch long‐term care system differs from other European systems (e.g. higher threshold for NH admission and trained elderly care physicians), this study explores the trends in PDPs in Dutch NH residents with dementia. METHODS: The study used data from nine studies, comprising two cross‐sectional studies, one cohort study, and six cluster‐randomized controlled trials, collected in Dutch NHs between 2003 and 2018. With multilevel logistic regression analysis, NHs as a random effect, we estimated the trends in PDPs overall and for five specific psychotropic drug groups (antipsychotics, antidepressants, anxiolytics, hypnotics, and anti‐dementia drugs), adjusting for confounders: age, gender, severity of dementia, severity of neuropsychiatric symptoms, and length of stay in NHs. RESULTS: The absolute prescription rate of antipsychotics was 37.5% in 2003 and decreased (OR = 0.947, 95% CI [0.926, 0.970]) every year. The absolute prescription rate of anti‐dementia drugs was 0.8% in 2003 and increased (OR = 1.162, 95% CI [1.105, 1.223]) per year. The absolute rate of overall PDPs declined from 62.7% in 2003 to 40.4% in 2018. CONCLUSIONS: Among Dutch NH residents with dementia, the odds of antipsychotics prescriptions decreased by 5.3% per year while the odds of anti‐dementia drug prescriptions increased by 16.2%. There were no distinct trends in antidepressants, anxiolytics, and hypnotics prescriptions. However, overall PDPs were still high. The PDPs in NH residents remain an issue of concern. John Wiley and Sons Inc. 2022-03-17 2022-04 /pmc/articles/PMC9311063/ /pubmed/35297551 http://dx.doi.org/10.1002/gps.5697 Text en © 2022 The Authors. International Journal of Geriatric Psychiatry published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Article
Du, Jiamin
Janus, Sarah
Voorthuis, Brenda
van Manen, Jeannette
Achterberg, Wilco
Smalbrugge, Martin
Zwijsen, Sandra
Gerritsen, Debby
Koopmans, Raymond
Zuidema, Sytse
Time trends in psychotropic drug prescriptions in Dutch nursing home residents with dementia between 2003 and 2018
title Time trends in psychotropic drug prescriptions in Dutch nursing home residents with dementia between 2003 and 2018
title_full Time trends in psychotropic drug prescriptions in Dutch nursing home residents with dementia between 2003 and 2018
title_fullStr Time trends in psychotropic drug prescriptions in Dutch nursing home residents with dementia between 2003 and 2018
title_full_unstemmed Time trends in psychotropic drug prescriptions in Dutch nursing home residents with dementia between 2003 and 2018
title_short Time trends in psychotropic drug prescriptions in Dutch nursing home residents with dementia between 2003 and 2018
title_sort time trends in psychotropic drug prescriptions in dutch nursing home residents with dementia between 2003 and 2018
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311063/
https://www.ncbi.nlm.nih.gov/pubmed/35297551
http://dx.doi.org/10.1002/gps.5697
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