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The role of sex in the association between cannabis use and working memory‐related brain activity
Although cannabis use patterns differ between men and women, studies on sex differences on the effects of cannabis on the brain and cognitive control are largely lacking. Working memory (WM) is a component of cognitive control believed to be involved in the development and maintenance of addiction....
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311233/ https://www.ncbi.nlm.nih.gov/pubmed/35293008 http://dx.doi.org/10.1002/jnr.25041 |
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author | Kroon, Emese Kuhns, Lauren N. Kaag, Anne Marije Filbey, Francesca Cousijn, Janna |
author_facet | Kroon, Emese Kuhns, Lauren N. Kaag, Anne Marije Filbey, Francesca Cousijn, Janna |
author_sort | Kroon, Emese |
collection | PubMed |
description | Although cannabis use patterns differ between men and women, studies on sex differences on the effects of cannabis on the brain and cognitive control are largely lacking. Working memory (WM) is a component of cognitive control believed to be involved in the development and maintenance of addiction. In this study, we evaluated the association between cannabis use and WM (load) related brain activity in a large sample, enabling us to assess sex effects in this association. The brain activity of 104 frequent cannabis users (63% men) and 85 controls (53% men) was recorded during an N‐back WM task. Behavioral results showed a significant interaction between WM load and group for both accuracy and reaction time, with cannabis users showing a relatively larger decrease in performance with increasing WM load. Cannabis users compared to controls showed a relatively smaller reduction in WM (load) related activity in the precuneus and posterior cingulate cortex at higher WM load. This WM (load) related activity was not associated with performance nor cannabis use and related problems. An exploratory analysis showed higher WM‐related activity in the superior frontal gyrus in men compared to women. While cannabis users showed higher WM (load) related activity in central nodes of the default mode network, this was not directly attributable to group specific worsening of performance under higher cognitive load. Further research is necessary to assess whether observed group differences increase with higher cognitive load, how group differences relate to measures of cannabis use, and how sex affects these group differences. |
format | Online Article Text |
id | pubmed-9311233 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93112332022-07-29 The role of sex in the association between cannabis use and working memory‐related brain activity Kroon, Emese Kuhns, Lauren N. Kaag, Anne Marije Filbey, Francesca Cousijn, Janna J Neurosci Res Research Articles Although cannabis use patterns differ between men and women, studies on sex differences on the effects of cannabis on the brain and cognitive control are largely lacking. Working memory (WM) is a component of cognitive control believed to be involved in the development and maintenance of addiction. In this study, we evaluated the association between cannabis use and WM (load) related brain activity in a large sample, enabling us to assess sex effects in this association. The brain activity of 104 frequent cannabis users (63% men) and 85 controls (53% men) was recorded during an N‐back WM task. Behavioral results showed a significant interaction between WM load and group for both accuracy and reaction time, with cannabis users showing a relatively larger decrease in performance with increasing WM load. Cannabis users compared to controls showed a relatively smaller reduction in WM (load) related activity in the precuneus and posterior cingulate cortex at higher WM load. This WM (load) related activity was not associated with performance nor cannabis use and related problems. An exploratory analysis showed higher WM‐related activity in the superior frontal gyrus in men compared to women. While cannabis users showed higher WM (load) related activity in central nodes of the default mode network, this was not directly attributable to group specific worsening of performance under higher cognitive load. Further research is necessary to assess whether observed group differences increase with higher cognitive load, how group differences relate to measures of cannabis use, and how sex affects these group differences. John Wiley and Sons Inc. 2022-03-15 2022-06 /pmc/articles/PMC9311233/ /pubmed/35293008 http://dx.doi.org/10.1002/jnr.25041 Text en © 2022 The Authors. Journal of Neuroscience Research published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Kroon, Emese Kuhns, Lauren N. Kaag, Anne Marije Filbey, Francesca Cousijn, Janna The role of sex in the association between cannabis use and working memory‐related brain activity |
title | The role of sex in the association between cannabis use and working memory‐related brain activity |
title_full | The role of sex in the association between cannabis use and working memory‐related brain activity |
title_fullStr | The role of sex in the association between cannabis use and working memory‐related brain activity |
title_full_unstemmed | The role of sex in the association between cannabis use and working memory‐related brain activity |
title_short | The role of sex in the association between cannabis use and working memory‐related brain activity |
title_sort | role of sex in the association between cannabis use and working memory‐related brain activity |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311233/ https://www.ncbi.nlm.nih.gov/pubmed/35293008 http://dx.doi.org/10.1002/jnr.25041 |
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