Mislocalization of protein kinase A drives pathology in Cushing’s syndrome

Mutations in the catalytic subunit of protein kinase A (PKAc) drive the stress hormone disorder adrenal Cushing’s syndrome. We define mechanisms of action for the PKAc-L205R and W196R variants. Proximity proteomic techniques demonstrate that both Cushing’s mutants are excluded from A kinase-anchorin...

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Detalles Bibliográficos
Autores principales: Omar, Mitchell H., Byrne, Dominic P., Jones, Kiana N., Lakey, Tyler M., Collins, Kerrie B., Lee, Kyung-Soon, Daly, Leonard A., Forbush, Katherine A., Lau, Ho-Tak, Golkowski, Martin, McKnight, G. Stanley, Breault, David T., Lefrançois-Martinez, Anne-Marie, Martinez, Antoine, Eyers, Claire E., Baird, Geoffrey S., Ong, Shao-En, Smith, F. Donelson, Eyers, Patrick A., Scott, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311266/
https://www.ncbi.nlm.nih.gov/pubmed/35830806
http://dx.doi.org/10.1016/j.celrep.2022.111073

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