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TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity

Cluster of differentiation 38 (CD38) is an ecto-enzyme expressed primarily on immune cells that metabolize nicotinamide adenine dinucleotide (NAD+) to adenosine diphosphate ribose or cyclic ADP-ribose and nicotinamide. Other substrates of CD38 include nicotinamide adenine dinucleotide phosphate and...

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Detalles Bibliográficos
Autores principales:	Ugamraj, Harshad S., Dang, Kevin, Ouisse, Laure-Hélène, Buelow, Benjamin, Chini, Eduardo N., Castello, Giulia, Allison, James, Clarke, Starlynn C, Davison, Laura M., Buelow, Roland, Deng, Rong, Iyer, Suhasini, Schellenberger, Ute, Manika, Sankar N., Bijpuria, Shipra, Musnier, Astrid, Poupon, Anne, Cuturi, Maria Cristina, van Schooten, Wim, Dalvi, Pranjali
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311320/ https://www.ncbi.nlm.nih.gov/pubmed/35867844 http://dx.doi.org/10.1080/19420862.2022.2095949

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