Deletion of the Lmna gene in fibroblasts causes senescence-associated dilated cardiomyopathy by activating the double-stranded DNA damage response and induction of senescence-associated secretory phenotype

INTRODUCTION: Mutations in the LMNA gene, encoding Lamin A/C (LMNA), are established causes of dilated cardiomyopathy (DCM). The phenotype is typically characterized by progressive cardiac conduction defects, arrhythmias, heart failure, and premature death. DCM is primarily considered a disease of c...

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Detalles Bibliográficos
Autores principales: Rouhi, Leila, Auguste, Gaelle, Zhou, Qiong, Lombardi, Raffaella, Olcum, Melis, Pourebrahim, Kimia, Cheedipudi, Sirisha M., Asghar, Saman, Hong, Kui, Robertson, Matthew J., Coarfa, Cristian, Gurha, Priyatansh, Marian, Ali J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311325/
https://www.ncbi.nlm.nih.gov/pubmed/35891706
http://dx.doi.org/10.20517/jca.2022.14

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