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Infection Sources and Klebsiella pneumoniae Antibiotic Susceptibilities in Endogenous Klebsiella Endophthalmitis

Endogenous endophthalmitis is an uncommon intraocular infection with potentially devastating consequences on vision. Klebsiella pneumoniae is highly prevalent in East Asian countries, with an increasing incidence recently worldwide. This retrospective study investigates infection sources and antibio...

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Autores principales: Chen, Kuan-Jen, Chen, Yen-Po, Chen, Yi-Hsing, Liu, Laura, Wang, Nan-Kai, Chao, An-Ning, Wu, Wei-Chi, Hwang, Yih-Shiou, Chou, Hung-Da, Kang, Eugene Yu-Chuan, Chen, Yen-Ting, Sun, Ming-Hui, Lai, Chi-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311537/
https://www.ncbi.nlm.nih.gov/pubmed/35884120
http://dx.doi.org/10.3390/antibiotics11070866
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author Chen, Kuan-Jen
Chen, Yen-Po
Chen, Yi-Hsing
Liu, Laura
Wang, Nan-Kai
Chao, An-Ning
Wu, Wei-Chi
Hwang, Yih-Shiou
Chou, Hung-Da
Kang, Eugene Yu-Chuan
Chen, Yen-Ting
Sun, Ming-Hui
Lai, Chi-Chun
author_facet Chen, Kuan-Jen
Chen, Yen-Po
Chen, Yi-Hsing
Liu, Laura
Wang, Nan-Kai
Chao, An-Ning
Wu, Wei-Chi
Hwang, Yih-Shiou
Chou, Hung-Da
Kang, Eugene Yu-Chuan
Chen, Yen-Ting
Sun, Ming-Hui
Lai, Chi-Chun
author_sort Chen, Kuan-Jen
collection PubMed
description Endogenous endophthalmitis is an uncommon intraocular infection with potentially devastating consequences on vision. Klebsiella pneumoniae is highly prevalent in East Asian countries, with an increasing incidence recently worldwide. This retrospective study investigates infection sources and antibiotic susceptibilities of K. pneumoniae in patients with endogenous K. pneumoniae endophthalmitis (EKE) in Northern Taiwan. One hundred and fifty-seven patients with EKE were reviewed between January 1996 and April 2019. Pyogenic liver abscess (120/157, 76.4%) was the most common infection source, followed by pneumonia (13, 8.3%), urinary tract infection (7, 4.5%), and intravenous drug use (4, 2.5%). Bilateral involvement was identified in 12.1% (19/157) of patients, especially in patients with pyogenic liver abscess (16/120, 13.3%), pneumonia (2/13, 15.4%), and urinary tract infection (1/7, 14.3%). The antibiotic susceptibility rates were 98.1%, 92.5%, 97.5%, 96.8%, 100%, 99.3%, and 100% for amikacin, cefuroxime, ceftazidime, ceftriaxone, carbapenems, ciprofloxacin, and levofloxacin, respectively. Four extended-spectrum β-lactamase-producing multidrug-resistant (MDR) K. pneumoniae isolates were identified. In conclusion, pyogenic liver abscess was the major infection source in EKE. In addition, K. pneumoniae was still highly susceptible to ceftazidime and amikacin, and the MDR K. pneumoniae isolates were not common in EKE.
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spelling pubmed-93115372022-07-26 Infection Sources and Klebsiella pneumoniae Antibiotic Susceptibilities in Endogenous Klebsiella Endophthalmitis Chen, Kuan-Jen Chen, Yen-Po Chen, Yi-Hsing Liu, Laura Wang, Nan-Kai Chao, An-Ning Wu, Wei-Chi Hwang, Yih-Shiou Chou, Hung-Da Kang, Eugene Yu-Chuan Chen, Yen-Ting Sun, Ming-Hui Lai, Chi-Chun Antibiotics (Basel) Communication Endogenous endophthalmitis is an uncommon intraocular infection with potentially devastating consequences on vision. Klebsiella pneumoniae is highly prevalent in East Asian countries, with an increasing incidence recently worldwide. This retrospective study investigates infection sources and antibiotic susceptibilities of K. pneumoniae in patients with endogenous K. pneumoniae endophthalmitis (EKE) in Northern Taiwan. One hundred and fifty-seven patients with EKE were reviewed between January 1996 and April 2019. Pyogenic liver abscess (120/157, 76.4%) was the most common infection source, followed by pneumonia (13, 8.3%), urinary tract infection (7, 4.5%), and intravenous drug use (4, 2.5%). Bilateral involvement was identified in 12.1% (19/157) of patients, especially in patients with pyogenic liver abscess (16/120, 13.3%), pneumonia (2/13, 15.4%), and urinary tract infection (1/7, 14.3%). The antibiotic susceptibility rates were 98.1%, 92.5%, 97.5%, 96.8%, 100%, 99.3%, and 100% for amikacin, cefuroxime, ceftazidime, ceftriaxone, carbapenems, ciprofloxacin, and levofloxacin, respectively. Four extended-spectrum β-lactamase-producing multidrug-resistant (MDR) K. pneumoniae isolates were identified. In conclusion, pyogenic liver abscess was the major infection source in EKE. In addition, K. pneumoniae was still highly susceptible to ceftazidime and amikacin, and the MDR K. pneumoniae isolates were not common in EKE. MDPI 2022-06-27 /pmc/articles/PMC9311537/ /pubmed/35884120 http://dx.doi.org/10.3390/antibiotics11070866 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Chen, Kuan-Jen
Chen, Yen-Po
Chen, Yi-Hsing
Liu, Laura
Wang, Nan-Kai
Chao, An-Ning
Wu, Wei-Chi
Hwang, Yih-Shiou
Chou, Hung-Da
Kang, Eugene Yu-Chuan
Chen, Yen-Ting
Sun, Ming-Hui
Lai, Chi-Chun
Infection Sources and Klebsiella pneumoniae Antibiotic Susceptibilities in Endogenous Klebsiella Endophthalmitis
title Infection Sources and Klebsiella pneumoniae Antibiotic Susceptibilities in Endogenous Klebsiella Endophthalmitis
title_full Infection Sources and Klebsiella pneumoniae Antibiotic Susceptibilities in Endogenous Klebsiella Endophthalmitis
title_fullStr Infection Sources and Klebsiella pneumoniae Antibiotic Susceptibilities in Endogenous Klebsiella Endophthalmitis
title_full_unstemmed Infection Sources and Klebsiella pneumoniae Antibiotic Susceptibilities in Endogenous Klebsiella Endophthalmitis
title_short Infection Sources and Klebsiella pneumoniae Antibiotic Susceptibilities in Endogenous Klebsiella Endophthalmitis
title_sort infection sources and klebsiella pneumoniae antibiotic susceptibilities in endogenous klebsiella endophthalmitis
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311537/
https://www.ncbi.nlm.nih.gov/pubmed/35884120
http://dx.doi.org/10.3390/antibiotics11070866
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