Cargando…

3,4′,5-Trimethoxy-trans-stilbene Alleviates Endothelial Dysfunction in Diabetic and Obese Mice via Activation of the AMPK/SIRT1/eNOS Pathway

3,4′,5-trimethoxy-trans-stilbene (TMS) is a methoxylated derivative of resveratrol. Previous studies showed the vaso-protective effects of resveratrol; nevertheless, research on this derivative is scarce. The current study aimed to explore whether TMS can alleviate endothelial dysfunction in diabeti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Chunxiu, Tan, Yi, Xu, Baojun, Wang, Yitao, Cheang, Wai-San
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311592/ https://www.ncbi.nlm.nih.gov/pubmed/35883777 http://dx.doi.org/10.3390/antiox11071286

Ejemplares similares

Two methoxy derivatives of resveratrol, 3,3′,4,5′-tetramethoxy-trans-stilbene and 3,4′,5-trimethoxy-trans-stilbene, suppress lipopolysaccharide-induced inflammation through inactivation of MAPK and NF-κB pathways in RAW 264.7 cells
por: Zhou, Chunxiu, et al.
Publicado: (2021)

3,5,4′-trimethoxy-trans-stilbene loaded PEG-PE micelles for the treatment of colon cancer
por: Wu, Jun-Yong, et al.
Publicado: (2019)

Novel indolic AMPK modulators induce vasodilatation through activation of the AMPK–eNOS–NO pathway
por: Sanz-Gómez, Marta, et al.
Publicado: (2022)

3,3′,4,5′-Tetramethoxy-trans-stilbene Improves Insulin Resistance by Activating the IRS/PI3K/Akt Pathway and Inhibiting Oxidative Stress
por: Tan, Yi, et al.
Publicado: (2022)

Kallistatin attenuates endothelial senescence by modulating Let‐7g‐mediated miR‐34a‐SIRT1‐eNOS pathway
por: Guo, Youming, et al.
Publicado: (2018)

Molecular mechanisms underlying pharmacological stimulation of eNOS expression and eNOS activity
por: Li, Huige, et al.
Publicado: (2009)

Lack of Endothelial α1AMPK Reverses the Vascular Protective Effects of Exercise by Causing eNOS Uncoupling
por: Jansen, Thomas, et al.
Publicado: (2021)

Total flavonoids from Astragalus alleviate endothelial dysfunction by activating the Akt/eNOS pathway
por: Liu, Qian, et al.
Publicado: (2017)

Regulation of miRNAs by Natural Antioxidants in Cardiovascular Diseases: Focus on SIRT1 and eNOS
por: Lee, Yunna, et al.
Publicado: (2021)

Multiple inducers of endothelial NOS (eNOS) dysfunction in sickle cell disease
por: Hebbel, Robert P., et al.
Publicado: (2021)

Eicosapentaenoic Acid Protects against Palmitic Acid-Induced Endothelial Dysfunction via Activation of the AMPK/eNOS Pathway
por: Lee, Che-Hsin, et al.
Publicado: (2014)

Berberine Protects against Palmitate-Induced Endothelial Dysfunction: Involvements of Upregulation of AMPK and eNOS and Downregulation of NOX4
por: Zhang, Ming, et al.
Publicado: (2013)

Metformin improves the angiogenic functions of endothelial progenitor cells via activating AMPK/eNOS pathway in diabetic mice
por: Yu, Jia-Wen, et al.
Publicado: (2016)

PKC-Dependent Phosphorylation of eNOS at T495 Regulates eNOS Coupling and Endothelial Barrier Function in Response to G(+) -Toxins
por: Chen, Feng, et al.
Publicado: (2014)

Endothelial NO Production Is Mandatory for Epigallocatechin-3-Gallate–induced Vasodilation: Results From eNOS Knockout (eNOS(−/−)) Mice
por: Lorenz, Mario, et al.
Publicado: (2015)

Recombinant Adiponectin Ameliorates Liver Ischemia Reperfusion Injury via Activating the AMPK/eNOS Pathway
por: Zhang, Chuanzhao, et al.
Publicado: (2013)

Saponin extract from Panax notoginseng promotesangiogenesis through AMPK- and eNOS-dependent pathways in HUVECs
por: Wang, Dongzhi, et al.
Publicado: (2017)

Neurogranin regulates eNOS function and endothelial activation
por: Cheriyan, Vino T., et al.
Publicado: (2020)

(-)-Epigallocatechin-3-Gallate Inhibits eNOS Uncoupling and Alleviates High Glucose-Induced Dysfunction and Apoptosis of Human Umbilical Vein Endothelial Cells by PI3K/AKT/eNOS Pathway
por: Zhang, Zhiyong, et al.
Publicado: (2020)

Heterozygous eNOS Deficient Mice as a Model to Examine the Effects of eNOS Haploinsufficiency on the Cerebral Circulation
por: Didion, Sean P.
Publicado: (2017)

mTOR contributes to endothelium-dependent vasorelaxation by promoting eNOS expression and preventing eNOS uncoupling
por: Wang, Yiying, et al.
Publicado: (2022)

Coptisine Attenuates Diabetes—Associated Endothelial Dysfunction through Inhibition of Endoplasmic Reticulum Stress and Oxidative Stress
por: Zhou, Yan, et al.
Publicado: (2021)

Irisin Lowers Blood Pressure by Improvement of Endothelial Dysfunction via AMPK‐Akt‐eNOS‐NO Pathway in the Spontaneously Hypertensive Rat
por: Fu, Jinjuan, et al.
Publicado: (2016)

Kang Le Xin Reduces Blood Pressure Through Inducing Endothelial-Dependent Vasodilation by Activating the AMPK-eNOS Pathway
por: Zhao, Yixiu, et al.
Publicado: (2020)

Capsaicin Alleviates Vascular Endothelial Dysfunction and Cardiomyopathy via TRPV1/eNOS Pathway in Diabetic Rats
por: Wang, Qiuyue, et al.
Publicado: (2022)

(-)-Epigallocatechin-3-Gallate Inhibits eNOS Uncoupling and Alleviates High Glucose-Induced Dysfunction and Apoptosis of Human Umbilical Vein Endothelial Cells by PI3K/AKT/eNOS Pathway [Corrigendum]
Publicado: (2020)

SIRT1 protects against myocardial ischemia–reperfusion injury via activating eNOS in diabetic rats
por: Ding, Mingge, et al.
Publicado: (2015)

3,4-Dihydroxyphenyl 3,4,5-trimethoxybenzoate
por: Hong, Won Ki, et al.
Publicado: (2007)

Association of genetic polymorphisms of eNOS with glaucoma
por: Liao, Qiong, et al.
Publicado: (2011)

Ursolic acid prevents doxorubicin‐induced cardiac toxicity in mice through eNOS activation and inhibition of eNOS uncoupling
por: Mu, Haiman, et al.
Publicado: (2019)

Activation of AMPK/miR-181b Axis Alleviates Endothelial Dysfunction and Vascular Inflammation in Diabetic Mice
por: Cheng, Chak-Kwong, et al.
Publicado: (2022)

Testosterone Deficiency Accelerates Neuronal and Vascular Aging of SAMP8 Mice: Protective Role of eNOS and SIRT1
por: Ota, Hidetaka, et al.
Publicado: (2012)

S-1-Propenylcysteine, a sulfur compound in aged garlic extract, alleviates cold-induced reduction in peripheral blood flow in rat via activation of the AMPK/eNOS/NO pathway
por: Ushijima, Mitsuyasu, et al.
Publicado: (2020)

Upregulation of iNOS and phosphorylated eNOS in the implantation‐induced blastocysts of mice
por: Seki, Misato, et al.
Publicado: (2023)

Data on eNOS T786 and G894T polymorphisms and peripheral blood eNOS mRNA levels in Sickle Cell Disease
por: Armenis, Iakovos, et al.
Publicado: (2016)

Reciprocal regulation of eNOS and caveolin-1 functions in endothelial cells
por: Chen, Zhenlong, et al.
Publicado: (2018)

Sex-specific eNOS activity and function in human endothelial cells
por: Cattaneo, Maria Grazia, et al.
Publicado: (2017)

Quantification of the Resveratrol Analogs trans-2,3-Dimethoxy-stilbene and trans-3,4-Dimethoxystilbene in Rat Plasma: Application to Pre-Clinical Pharmacokinetic Studies
por: Ng, Shermain Yali, et al.
Publicado: (2014)

Endothelial cell-specific loss of eNOS differentially affects endothelial function
por: Bu, Shuhan, et al.
Publicado: (2022)

Free fatty acids induce coronary microvascular dysfunction via inhibition of the AMPK/KLF2/eNOS signaling pathway
por: Zhang, Yanda, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_nj52ns9qvghi1g3fv129ti12ca