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Relevance of Diabetic Retinopathy with AGEs and Carotenoid Levels Assessed by Skin Sensors

Advanced glycation end products (AGEs) and carotenoids, the major prooxidants and antioxidants in vivo, respectively, are thought to be associated with diabetes mellitus (DM). To estimate AGEs and carotenoid levels simultaneously in patients with DM, we used noninvasive fingertip skin sensors. The s...

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Autores principales: Sasaki, Junichi, Takayanagi, Yuji, Kadoh, Yoichi, Tanito, Masaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311940/
https://www.ncbi.nlm.nih.gov/pubmed/35883861
http://dx.doi.org/10.3390/antiox11071370
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author Sasaki, Junichi
Takayanagi, Yuji
Kadoh, Yoichi
Tanito, Masaki
author_facet Sasaki, Junichi
Takayanagi, Yuji
Kadoh, Yoichi
Tanito, Masaki
author_sort Sasaki, Junichi
collection PubMed
description Advanced glycation end products (AGEs) and carotenoids, the major prooxidants and antioxidants in vivo, respectively, are thought to be associated with diabetes mellitus (DM). To estimate AGEs and carotenoid levels simultaneously in patients with DM, we used noninvasive fingertip skin sensors. The study population included 249 eyes of 249 Japanese subjects (130 men, 119 women; mean age ± standard deviation, 69.9 ± 12.0 years). Ninety-three patients had DM, which included diabetic retinopathy (DR) (n = 44) and no DR (NDR) (n = 49), and 156 controls. Compared to the controls (0.44 ± 0.07 arbitrary unit (A.U.)), the AGEs scores were significantly higher in DM (0.47 ± 0.09, p = 0.029) and DR (0.49 ± 0.08, p = 0.0006) patients; no difference was seen between NDR (0.45 ± 0.09, p = 0.83) and controls. Multivariate analyses indicated that a higher AGEs level is a risk factor for DR (r = 0.030, p = 0.0025). However, the carotenoid scores did not differ in any comparisons between the controls (327.7 ± 137.0 O.D.) and patients with DM (324.7 ± 126.4, p = 0.86), NDR (320.4 ± 123.6, p = 0.93), or DR (329.4 ± 130.8, p = 0.93). The carotenoid scores correlated negatively with the AGEs scores (r = −0.21, p = 0.0007), and reflected the Veggie intake score (p < 0.0001). In patients with DM, estimations of AGEs and carotenoid levels using skin sensors can be useful for assessing their risk of DR and vegetable intake, respectively.
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spelling pubmed-93119402022-07-26 Relevance of Diabetic Retinopathy with AGEs and Carotenoid Levels Assessed by Skin Sensors Sasaki, Junichi Takayanagi, Yuji Kadoh, Yoichi Tanito, Masaki Antioxidants (Basel) Article Advanced glycation end products (AGEs) and carotenoids, the major prooxidants and antioxidants in vivo, respectively, are thought to be associated with diabetes mellitus (DM). To estimate AGEs and carotenoid levels simultaneously in patients with DM, we used noninvasive fingertip skin sensors. The study population included 249 eyes of 249 Japanese subjects (130 men, 119 women; mean age ± standard deviation, 69.9 ± 12.0 years). Ninety-three patients had DM, which included diabetic retinopathy (DR) (n = 44) and no DR (NDR) (n = 49), and 156 controls. Compared to the controls (0.44 ± 0.07 arbitrary unit (A.U.)), the AGEs scores were significantly higher in DM (0.47 ± 0.09, p = 0.029) and DR (0.49 ± 0.08, p = 0.0006) patients; no difference was seen between NDR (0.45 ± 0.09, p = 0.83) and controls. Multivariate analyses indicated that a higher AGEs level is a risk factor for DR (r = 0.030, p = 0.0025). However, the carotenoid scores did not differ in any comparisons between the controls (327.7 ± 137.0 O.D.) and patients with DM (324.7 ± 126.4, p = 0.86), NDR (320.4 ± 123.6, p = 0.93), or DR (329.4 ± 130.8, p = 0.93). The carotenoid scores correlated negatively with the AGEs scores (r = −0.21, p = 0.0007), and reflected the Veggie intake score (p < 0.0001). In patients with DM, estimations of AGEs and carotenoid levels using skin sensors can be useful for assessing their risk of DR and vegetable intake, respectively. MDPI 2022-07-14 /pmc/articles/PMC9311940/ /pubmed/35883861 http://dx.doi.org/10.3390/antiox11071370 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sasaki, Junichi
Takayanagi, Yuji
Kadoh, Yoichi
Tanito, Masaki
Relevance of Diabetic Retinopathy with AGEs and Carotenoid Levels Assessed by Skin Sensors
title Relevance of Diabetic Retinopathy with AGEs and Carotenoid Levels Assessed by Skin Sensors
title_full Relevance of Diabetic Retinopathy with AGEs and Carotenoid Levels Assessed by Skin Sensors
title_fullStr Relevance of Diabetic Retinopathy with AGEs and Carotenoid Levels Assessed by Skin Sensors
title_full_unstemmed Relevance of Diabetic Retinopathy with AGEs and Carotenoid Levels Assessed by Skin Sensors
title_short Relevance of Diabetic Retinopathy with AGEs and Carotenoid Levels Assessed by Skin Sensors
title_sort relevance of diabetic retinopathy with ages and carotenoid levels assessed by skin sensors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311940/
https://www.ncbi.nlm.nih.gov/pubmed/35883861
http://dx.doi.org/10.3390/antiox11071370
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