Cargando…

Development of a Modular Tissue Phantom for Evaluating Vascular Access Devices

Central vascular access (CVA) may be critical for trauma care and stabilizing the casualty. However, it requires skilled personnel, often unavailable during remote medical situations and combat casualty care scenarios. Automated CVA medical devices have the potential to make life-saving therapeutics...

Descripción completa

Detalles Bibliográficos
Autores principales: Boice, Emily N., Berard, David, Gonzalez, Jose M., Hernandez Torres, Sofia I., Knowlton, Zechariah J., Avital, Guy, Snider, Eric J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311941/
https://www.ncbi.nlm.nih.gov/pubmed/35877370
http://dx.doi.org/10.3390/bioengineering9070319
_version_ 1784753717542649856
author Boice, Emily N.
Berard, David
Gonzalez, Jose M.
Hernandez Torres, Sofia I.
Knowlton, Zechariah J.
Avital, Guy
Snider, Eric J.
author_facet Boice, Emily N.
Berard, David
Gonzalez, Jose M.
Hernandez Torres, Sofia I.
Knowlton, Zechariah J.
Avital, Guy
Snider, Eric J.
author_sort Boice, Emily N.
collection PubMed
description Central vascular access (CVA) may be critical for trauma care and stabilizing the casualty. However, it requires skilled personnel, often unavailable during remote medical situations and combat casualty care scenarios. Automated CVA medical devices have the potential to make life-saving therapeutics available in these resource-limited scenarios, but they must be properly designed. Unfortunately, currently available tissue phantoms are inadequate for this use, resulting in delayed product development. Here, we present a tissue phantom that is modular in design, allowing for adjustable flow rate, circulating fluid pressure, vessel diameter, and vessel positions. The phantom consists of a gelatin cast using a 3D-printed mold with inserts representing vessels and bone locations. These removable inserts allow for tubing insertion which can mimic normal and hypovolemic flow, as well as pressure and vessel diameters. Trauma to the vessel wall is assessed using quantification of leak rates from the tubing after removal from the model. Lastly, the phantom can be adjusted to swine or human anatomy, including modeling the entire neurovascular bundle. Overall, this model can better recreate severe hypovolemic trauma cases and subject variability than commercial CVA trainers and may potentially accelerate automated CVA device development.
format Online
Article
Text
id pubmed-9311941
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93119412022-07-26 Development of a Modular Tissue Phantom for Evaluating Vascular Access Devices Boice, Emily N. Berard, David Gonzalez, Jose M. Hernandez Torres, Sofia I. Knowlton, Zechariah J. Avital, Guy Snider, Eric J. Bioengineering (Basel) Article Central vascular access (CVA) may be critical for trauma care and stabilizing the casualty. However, it requires skilled personnel, often unavailable during remote medical situations and combat casualty care scenarios. Automated CVA medical devices have the potential to make life-saving therapeutics available in these resource-limited scenarios, but they must be properly designed. Unfortunately, currently available tissue phantoms are inadequate for this use, resulting in delayed product development. Here, we present a tissue phantom that is modular in design, allowing for adjustable flow rate, circulating fluid pressure, vessel diameter, and vessel positions. The phantom consists of a gelatin cast using a 3D-printed mold with inserts representing vessels and bone locations. These removable inserts allow for tubing insertion which can mimic normal and hypovolemic flow, as well as pressure and vessel diameters. Trauma to the vessel wall is assessed using quantification of leak rates from the tubing after removal from the model. Lastly, the phantom can be adjusted to swine or human anatomy, including modeling the entire neurovascular bundle. Overall, this model can better recreate severe hypovolemic trauma cases and subject variability than commercial CVA trainers and may potentially accelerate automated CVA device development. MDPI 2022-07-15 /pmc/articles/PMC9311941/ /pubmed/35877370 http://dx.doi.org/10.3390/bioengineering9070319 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Boice, Emily N.
Berard, David
Gonzalez, Jose M.
Hernandez Torres, Sofia I.
Knowlton, Zechariah J.
Avital, Guy
Snider, Eric J.
Development of a Modular Tissue Phantom for Evaluating Vascular Access Devices
title Development of a Modular Tissue Phantom for Evaluating Vascular Access Devices
title_full Development of a Modular Tissue Phantom for Evaluating Vascular Access Devices
title_fullStr Development of a Modular Tissue Phantom for Evaluating Vascular Access Devices
title_full_unstemmed Development of a Modular Tissue Phantom for Evaluating Vascular Access Devices
title_short Development of a Modular Tissue Phantom for Evaluating Vascular Access Devices
title_sort development of a modular tissue phantom for evaluating vascular access devices
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311941/
https://www.ncbi.nlm.nih.gov/pubmed/35877370
http://dx.doi.org/10.3390/bioengineering9070319
work_keys_str_mv AT boiceemilyn developmentofamodulartissuephantomforevaluatingvascularaccessdevices
AT berarddavid developmentofamodulartissuephantomforevaluatingvascularaccessdevices
AT gonzalezjosem developmentofamodulartissuephantomforevaluatingvascularaccessdevices
AT hernandeztorressofiai developmentofamodulartissuephantomforevaluatingvascularaccessdevices
AT knowltonzechariahj developmentofamodulartissuephantomforevaluatingvascularaccessdevices
AT avitalguy developmentofamodulartissuephantomforevaluatingvascularaccessdevices
AT sniderericj developmentofamodulartissuephantomforevaluatingvascularaccessdevices