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Development of a Modular Tissue Phantom for Evaluating Vascular Access Devices
Central vascular access (CVA) may be critical for trauma care and stabilizing the casualty. However, it requires skilled personnel, often unavailable during remote medical situations and combat casualty care scenarios. Automated CVA medical devices have the potential to make life-saving therapeutics...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311941/ https://www.ncbi.nlm.nih.gov/pubmed/35877370 http://dx.doi.org/10.3390/bioengineering9070319 |
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author | Boice, Emily N. Berard, David Gonzalez, Jose M. Hernandez Torres, Sofia I. Knowlton, Zechariah J. Avital, Guy Snider, Eric J. |
author_facet | Boice, Emily N. Berard, David Gonzalez, Jose M. Hernandez Torres, Sofia I. Knowlton, Zechariah J. Avital, Guy Snider, Eric J. |
author_sort | Boice, Emily N. |
collection | PubMed |
description | Central vascular access (CVA) may be critical for trauma care and stabilizing the casualty. However, it requires skilled personnel, often unavailable during remote medical situations and combat casualty care scenarios. Automated CVA medical devices have the potential to make life-saving therapeutics available in these resource-limited scenarios, but they must be properly designed. Unfortunately, currently available tissue phantoms are inadequate for this use, resulting in delayed product development. Here, we present a tissue phantom that is modular in design, allowing for adjustable flow rate, circulating fluid pressure, vessel diameter, and vessel positions. The phantom consists of a gelatin cast using a 3D-printed mold with inserts representing vessels and bone locations. These removable inserts allow for tubing insertion which can mimic normal and hypovolemic flow, as well as pressure and vessel diameters. Trauma to the vessel wall is assessed using quantification of leak rates from the tubing after removal from the model. Lastly, the phantom can be adjusted to swine or human anatomy, including modeling the entire neurovascular bundle. Overall, this model can better recreate severe hypovolemic trauma cases and subject variability than commercial CVA trainers and may potentially accelerate automated CVA device development. |
format | Online Article Text |
id | pubmed-9311941 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93119412022-07-26 Development of a Modular Tissue Phantom for Evaluating Vascular Access Devices Boice, Emily N. Berard, David Gonzalez, Jose M. Hernandez Torres, Sofia I. Knowlton, Zechariah J. Avital, Guy Snider, Eric J. Bioengineering (Basel) Article Central vascular access (CVA) may be critical for trauma care and stabilizing the casualty. However, it requires skilled personnel, often unavailable during remote medical situations and combat casualty care scenarios. Automated CVA medical devices have the potential to make life-saving therapeutics available in these resource-limited scenarios, but they must be properly designed. Unfortunately, currently available tissue phantoms are inadequate for this use, resulting in delayed product development. Here, we present a tissue phantom that is modular in design, allowing for adjustable flow rate, circulating fluid pressure, vessel diameter, and vessel positions. The phantom consists of a gelatin cast using a 3D-printed mold with inserts representing vessels and bone locations. These removable inserts allow for tubing insertion which can mimic normal and hypovolemic flow, as well as pressure and vessel diameters. Trauma to the vessel wall is assessed using quantification of leak rates from the tubing after removal from the model. Lastly, the phantom can be adjusted to swine or human anatomy, including modeling the entire neurovascular bundle. Overall, this model can better recreate severe hypovolemic trauma cases and subject variability than commercial CVA trainers and may potentially accelerate automated CVA device development. MDPI 2022-07-15 /pmc/articles/PMC9311941/ /pubmed/35877370 http://dx.doi.org/10.3390/bioengineering9070319 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Boice, Emily N. Berard, David Gonzalez, Jose M. Hernandez Torres, Sofia I. Knowlton, Zechariah J. Avital, Guy Snider, Eric J. Development of a Modular Tissue Phantom for Evaluating Vascular Access Devices |
title | Development of a Modular Tissue Phantom for Evaluating Vascular Access Devices |
title_full | Development of a Modular Tissue Phantom for Evaluating Vascular Access Devices |
title_fullStr | Development of a Modular Tissue Phantom for Evaluating Vascular Access Devices |
title_full_unstemmed | Development of a Modular Tissue Phantom for Evaluating Vascular Access Devices |
title_short | Development of a Modular Tissue Phantom for Evaluating Vascular Access Devices |
title_sort | development of a modular tissue phantom for evaluating vascular access devices |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311941/ https://www.ncbi.nlm.nih.gov/pubmed/35877370 http://dx.doi.org/10.3390/bioengineering9070319 |
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