Cargando…

Oxidative Stress Induced by High Salt Diet—Possible Implications for Development and Clinical Manifestation of Cutaneous Inflammation and Endothelial Dysfunction in Psoriasis vulgaris

Although oxidative stress is recognized as an important effector mechanism of the immune system, uncontrolled formation of reactive oxygen and nitrogen species promotes excessive tissue damage and leads to disease development. In view of this, increased dietary salt intake has been found to damage r...

Descripción completa

Detalles Bibliográficos
Autores principales: Krajina, Ivana, Stupin, Ana, Šola, Marija, Mihalj, Martina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311978/
https://www.ncbi.nlm.nih.gov/pubmed/35883760
http://dx.doi.org/10.3390/antiox11071269
_version_ 1784753726992416768
author Krajina, Ivana
Stupin, Ana
Šola, Marija
Mihalj, Martina
author_facet Krajina, Ivana
Stupin, Ana
Šola, Marija
Mihalj, Martina
author_sort Krajina, Ivana
collection PubMed
description Although oxidative stress is recognized as an important effector mechanism of the immune system, uncontrolled formation of reactive oxygen and nitrogen species promotes excessive tissue damage and leads to disease development. In view of this, increased dietary salt intake has been found to damage redox systems in the vessel wall, resulting in endothelial dysfunction associated with NO uncoupling, inflammation, vascular wall remodeling and, eventually, atherosclerosis. Several studies have reported increased systemic oxidative stress accompanied by reduced antioxidant capacity following a high salt diet. In addition, vigorous ionic effects on the immune mechanisms, such as (trans)differentiation of T lymphocytes are emerging, which together with the evidence of NaCl accumulation in certain tissues warrants a re-examination of the data derived from in vitro research, in which the ionic influence was excluded. Psoriasis vulgaris (PV), as a primarily Th17-driven inflammatory skin disease with proven inflammation-induced accumulation of sodium chloride in the skin, merits our interest in the role of oxidative stress in the pathogenesis of PV, as well as in the possible beneficial effects that could be achieved through modulation of dietary salt intake and antioxidant supplementation.
format Online
Article
Text
id pubmed-9311978
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93119782022-07-26 Oxidative Stress Induced by High Salt Diet—Possible Implications for Development and Clinical Manifestation of Cutaneous Inflammation and Endothelial Dysfunction in Psoriasis vulgaris Krajina, Ivana Stupin, Ana Šola, Marija Mihalj, Martina Antioxidants (Basel) Review Although oxidative stress is recognized as an important effector mechanism of the immune system, uncontrolled formation of reactive oxygen and nitrogen species promotes excessive tissue damage and leads to disease development. In view of this, increased dietary salt intake has been found to damage redox systems in the vessel wall, resulting in endothelial dysfunction associated with NO uncoupling, inflammation, vascular wall remodeling and, eventually, atherosclerosis. Several studies have reported increased systemic oxidative stress accompanied by reduced antioxidant capacity following a high salt diet. In addition, vigorous ionic effects on the immune mechanisms, such as (trans)differentiation of T lymphocytes are emerging, which together with the evidence of NaCl accumulation in certain tissues warrants a re-examination of the data derived from in vitro research, in which the ionic influence was excluded. Psoriasis vulgaris (PV), as a primarily Th17-driven inflammatory skin disease with proven inflammation-induced accumulation of sodium chloride in the skin, merits our interest in the role of oxidative stress in the pathogenesis of PV, as well as in the possible beneficial effects that could be achieved through modulation of dietary salt intake and antioxidant supplementation. MDPI 2022-06-27 /pmc/articles/PMC9311978/ /pubmed/35883760 http://dx.doi.org/10.3390/antiox11071269 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Krajina, Ivana
Stupin, Ana
Šola, Marija
Mihalj, Martina
Oxidative Stress Induced by High Salt Diet—Possible Implications for Development and Clinical Manifestation of Cutaneous Inflammation and Endothelial Dysfunction in Psoriasis vulgaris
title Oxidative Stress Induced by High Salt Diet—Possible Implications for Development and Clinical Manifestation of Cutaneous Inflammation and Endothelial Dysfunction in Psoriasis vulgaris
title_full Oxidative Stress Induced by High Salt Diet—Possible Implications for Development and Clinical Manifestation of Cutaneous Inflammation and Endothelial Dysfunction in Psoriasis vulgaris
title_fullStr Oxidative Stress Induced by High Salt Diet—Possible Implications for Development and Clinical Manifestation of Cutaneous Inflammation and Endothelial Dysfunction in Psoriasis vulgaris
title_full_unstemmed Oxidative Stress Induced by High Salt Diet—Possible Implications for Development and Clinical Manifestation of Cutaneous Inflammation and Endothelial Dysfunction in Psoriasis vulgaris
title_short Oxidative Stress Induced by High Salt Diet—Possible Implications for Development and Clinical Manifestation of Cutaneous Inflammation and Endothelial Dysfunction in Psoriasis vulgaris
title_sort oxidative stress induced by high salt diet—possible implications for development and clinical manifestation of cutaneous inflammation and endothelial dysfunction in psoriasis vulgaris
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311978/
https://www.ncbi.nlm.nih.gov/pubmed/35883760
http://dx.doi.org/10.3390/antiox11071269
work_keys_str_mv AT krajinaivana oxidativestressinducedbyhighsaltdietpossibleimplicationsfordevelopmentandclinicalmanifestationofcutaneousinflammationandendothelialdysfunctioninpsoriasisvulgaris
AT stupinana oxidativestressinducedbyhighsaltdietpossibleimplicationsfordevelopmentandclinicalmanifestationofcutaneousinflammationandendothelialdysfunctioninpsoriasisvulgaris
AT solamarija oxidativestressinducedbyhighsaltdietpossibleimplicationsfordevelopmentandclinicalmanifestationofcutaneousinflammationandendothelialdysfunctioninpsoriasisvulgaris
AT mihaljmartina oxidativestressinducedbyhighsaltdietpossibleimplicationsfordevelopmentandclinicalmanifestationofcutaneousinflammationandendothelialdysfunctioninpsoriasisvulgaris