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Ebselen Interferes with Alzheimer’s Disease by Regulating Mitochondrial Function

(1) Background: With unknown causes and no effective treatment available, Alzheimer’s disease (AD) places enormous pressure on families and society. Our previous study had shown that Ebselen at a high concentration (10.94 μM) improved the cognition of triple-transgenic AD (3×Tg-AD) mice and alleviat...

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Autores principales: Li, Xuexia, Shi, Qingqing, Xu, Hao, Xiong, Yufang, Wang, Chao, Le, Linfeng, Lian, Junliang, Wu, Guoli, Peng, Feiyuan, Liu, Qiong, Du, Xiubo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312019/
https://www.ncbi.nlm.nih.gov/pubmed/35883841
http://dx.doi.org/10.3390/antiox11071350
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author Li, Xuexia
Shi, Qingqing
Xu, Hao
Xiong, Yufang
Wang, Chao
Le, Linfeng
Lian, Junliang
Wu, Guoli
Peng, Feiyuan
Liu, Qiong
Du, Xiubo
author_facet Li, Xuexia
Shi, Qingqing
Xu, Hao
Xiong, Yufang
Wang, Chao
Le, Linfeng
Lian, Junliang
Wu, Guoli
Peng, Feiyuan
Liu, Qiong
Du, Xiubo
author_sort Li, Xuexia
collection PubMed
description (1) Background: With unknown causes and no effective treatment available, Alzheimer’s disease (AD) places enormous pressure on families and society. Our previous study had shown that Ebselen at a high concentration (10.94 μM) improved the cognition of triple-transgenic AD (3×Tg-AD) mice and alleviated the related pathological indicators but showed toxicity to the mice. Here, we dedicated to study the therapeutic effect and molecular mechanism of Ebselen at a much lower concentration on 3×Tg-AD mice. (2) Methods: Various behavioral experiments were applied to detect the behavioral ability of mice. Western blot, thioflavin T staining and a transmission electron microscope were used to evaluate the pathology of AD mice. The mitochondrial membrane potential and respiration were assessed with the corresponding assay kit. (3) Results: Ebselen remarkably increased cognitive ability of AD mice, eliminated β-Amyloid (Aβ) oligomers and recovered the synaptic damage in AD mice brain. In addition, the destroyed mitochondrial morphologies and function were repaired by Ebselen through ameliorating mitochondrial energy metabolism, mitochondrial biogenesis and mitochondrial fusion/fission balance in N2a-SW cells and brain tissues of AD mice. (4) Conclusions: This research indicated that Ebselen might exert its therapeutic effect via protecting mitochondria in AD.
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spelling pubmed-93120192022-07-26 Ebselen Interferes with Alzheimer’s Disease by Regulating Mitochondrial Function Li, Xuexia Shi, Qingqing Xu, Hao Xiong, Yufang Wang, Chao Le, Linfeng Lian, Junliang Wu, Guoli Peng, Feiyuan Liu, Qiong Du, Xiubo Antioxidants (Basel) Article (1) Background: With unknown causes and no effective treatment available, Alzheimer’s disease (AD) places enormous pressure on families and society. Our previous study had shown that Ebselen at a high concentration (10.94 μM) improved the cognition of triple-transgenic AD (3×Tg-AD) mice and alleviated the related pathological indicators but showed toxicity to the mice. Here, we dedicated to study the therapeutic effect and molecular mechanism of Ebselen at a much lower concentration on 3×Tg-AD mice. (2) Methods: Various behavioral experiments were applied to detect the behavioral ability of mice. Western blot, thioflavin T staining and a transmission electron microscope were used to evaluate the pathology of AD mice. The mitochondrial membrane potential and respiration were assessed with the corresponding assay kit. (3) Results: Ebselen remarkably increased cognitive ability of AD mice, eliminated β-Amyloid (Aβ) oligomers and recovered the synaptic damage in AD mice brain. In addition, the destroyed mitochondrial morphologies and function were repaired by Ebselen through ameliorating mitochondrial energy metabolism, mitochondrial biogenesis and mitochondrial fusion/fission balance in N2a-SW cells and brain tissues of AD mice. (4) Conclusions: This research indicated that Ebselen might exert its therapeutic effect via protecting mitochondria in AD. MDPI 2022-07-11 /pmc/articles/PMC9312019/ /pubmed/35883841 http://dx.doi.org/10.3390/antiox11071350 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Xuexia
Shi, Qingqing
Xu, Hao
Xiong, Yufang
Wang, Chao
Le, Linfeng
Lian, Junliang
Wu, Guoli
Peng, Feiyuan
Liu, Qiong
Du, Xiubo
Ebselen Interferes with Alzheimer’s Disease by Regulating Mitochondrial Function
title Ebselen Interferes with Alzheimer’s Disease by Regulating Mitochondrial Function
title_full Ebselen Interferes with Alzheimer’s Disease by Regulating Mitochondrial Function
title_fullStr Ebselen Interferes with Alzheimer’s Disease by Regulating Mitochondrial Function
title_full_unstemmed Ebselen Interferes with Alzheimer’s Disease by Regulating Mitochondrial Function
title_short Ebselen Interferes with Alzheimer’s Disease by Regulating Mitochondrial Function
title_sort ebselen interferes with alzheimer’s disease by regulating mitochondrial function
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312019/
https://www.ncbi.nlm.nih.gov/pubmed/35883841
http://dx.doi.org/10.3390/antiox11071350
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