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Ebselen Interferes with Alzheimer’s Disease by Regulating Mitochondrial Function
(1) Background: With unknown causes and no effective treatment available, Alzheimer’s disease (AD) places enormous pressure on families and society. Our previous study had shown that Ebselen at a high concentration (10.94 μM) improved the cognition of triple-transgenic AD (3×Tg-AD) mice and alleviat...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312019/ https://www.ncbi.nlm.nih.gov/pubmed/35883841 http://dx.doi.org/10.3390/antiox11071350 |
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author | Li, Xuexia Shi, Qingqing Xu, Hao Xiong, Yufang Wang, Chao Le, Linfeng Lian, Junliang Wu, Guoli Peng, Feiyuan Liu, Qiong Du, Xiubo |
author_facet | Li, Xuexia Shi, Qingqing Xu, Hao Xiong, Yufang Wang, Chao Le, Linfeng Lian, Junliang Wu, Guoli Peng, Feiyuan Liu, Qiong Du, Xiubo |
author_sort | Li, Xuexia |
collection | PubMed |
description | (1) Background: With unknown causes and no effective treatment available, Alzheimer’s disease (AD) places enormous pressure on families and society. Our previous study had shown that Ebselen at a high concentration (10.94 μM) improved the cognition of triple-transgenic AD (3×Tg-AD) mice and alleviated the related pathological indicators but showed toxicity to the mice. Here, we dedicated to study the therapeutic effect and molecular mechanism of Ebselen at a much lower concentration on 3×Tg-AD mice. (2) Methods: Various behavioral experiments were applied to detect the behavioral ability of mice. Western blot, thioflavin T staining and a transmission electron microscope were used to evaluate the pathology of AD mice. The mitochondrial membrane potential and respiration were assessed with the corresponding assay kit. (3) Results: Ebselen remarkably increased cognitive ability of AD mice, eliminated β-Amyloid (Aβ) oligomers and recovered the synaptic damage in AD mice brain. In addition, the destroyed mitochondrial morphologies and function were repaired by Ebselen through ameliorating mitochondrial energy metabolism, mitochondrial biogenesis and mitochondrial fusion/fission balance in N2a-SW cells and brain tissues of AD mice. (4) Conclusions: This research indicated that Ebselen might exert its therapeutic effect via protecting mitochondria in AD. |
format | Online Article Text |
id | pubmed-9312019 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93120192022-07-26 Ebselen Interferes with Alzheimer’s Disease by Regulating Mitochondrial Function Li, Xuexia Shi, Qingqing Xu, Hao Xiong, Yufang Wang, Chao Le, Linfeng Lian, Junliang Wu, Guoli Peng, Feiyuan Liu, Qiong Du, Xiubo Antioxidants (Basel) Article (1) Background: With unknown causes and no effective treatment available, Alzheimer’s disease (AD) places enormous pressure on families and society. Our previous study had shown that Ebselen at a high concentration (10.94 μM) improved the cognition of triple-transgenic AD (3×Tg-AD) mice and alleviated the related pathological indicators but showed toxicity to the mice. Here, we dedicated to study the therapeutic effect and molecular mechanism of Ebselen at a much lower concentration on 3×Tg-AD mice. (2) Methods: Various behavioral experiments were applied to detect the behavioral ability of mice. Western blot, thioflavin T staining and a transmission electron microscope were used to evaluate the pathology of AD mice. The mitochondrial membrane potential and respiration were assessed with the corresponding assay kit. (3) Results: Ebselen remarkably increased cognitive ability of AD mice, eliminated β-Amyloid (Aβ) oligomers and recovered the synaptic damage in AD mice brain. In addition, the destroyed mitochondrial morphologies and function were repaired by Ebselen through ameliorating mitochondrial energy metabolism, mitochondrial biogenesis and mitochondrial fusion/fission balance in N2a-SW cells and brain tissues of AD mice. (4) Conclusions: This research indicated that Ebselen might exert its therapeutic effect via protecting mitochondria in AD. MDPI 2022-07-11 /pmc/articles/PMC9312019/ /pubmed/35883841 http://dx.doi.org/10.3390/antiox11071350 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Li, Xuexia Shi, Qingqing Xu, Hao Xiong, Yufang Wang, Chao Le, Linfeng Lian, Junliang Wu, Guoli Peng, Feiyuan Liu, Qiong Du, Xiubo Ebselen Interferes with Alzheimer’s Disease by Regulating Mitochondrial Function |
title | Ebselen Interferes with Alzheimer’s Disease by Regulating Mitochondrial Function |
title_full | Ebselen Interferes with Alzheimer’s Disease by Regulating Mitochondrial Function |
title_fullStr | Ebselen Interferes with Alzheimer’s Disease by Regulating Mitochondrial Function |
title_full_unstemmed | Ebselen Interferes with Alzheimer’s Disease by Regulating Mitochondrial Function |
title_short | Ebselen Interferes with Alzheimer’s Disease by Regulating Mitochondrial Function |
title_sort | ebselen interferes with alzheimer’s disease by regulating mitochondrial function |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312019/ https://www.ncbi.nlm.nih.gov/pubmed/35883841 http://dx.doi.org/10.3390/antiox11071350 |
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