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Regional Variations in Outpatient Antibiotic Prescribing in Germany: A Small Area Analysis Based on Claims Data

A comprehensive small area description of regional variations in outpatient antibiotic prescribing in Germany is lacking. Using the German Pharmacoepidemiological Research Database (GePaRD), a claims database covering ~20% of the German population, we determined the age- and sex-standardized prescri...

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Autores principales: Scholle, Oliver, Asendorf, Marieke, Buck, Christoph, Grill, Susann, Jones, Christopher, Kollhorst, Bianca, Riedel, Oliver, Schüz, Benjamin, Haug, Ulrike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312140/
https://www.ncbi.nlm.nih.gov/pubmed/35884090
http://dx.doi.org/10.3390/antibiotics11070836
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author Scholle, Oliver
Asendorf, Marieke
Buck, Christoph
Grill, Susann
Jones, Christopher
Kollhorst, Bianca
Riedel, Oliver
Schüz, Benjamin
Haug, Ulrike
author_facet Scholle, Oliver
Asendorf, Marieke
Buck, Christoph
Grill, Susann
Jones, Christopher
Kollhorst, Bianca
Riedel, Oliver
Schüz, Benjamin
Haug, Ulrike
author_sort Scholle, Oliver
collection PubMed
description A comprehensive small area description of regional variations in outpatient antibiotic prescribing in Germany is lacking. Using the German Pharmacoepidemiological Research Database (GePaRD), a claims database covering ~20% of the German population, we determined the age- and sex-standardized prescription rates of antibiotics (number of outpatient prescriptions per 1000 persons/year). We calculated these prescription rates overall and on the level of 401 German districts for the calendar years 2010 and 2018. In 2018, the standardized prescription rate of antibiotics in the total study population was 23% lower than in 2010 (442 vs. 575 per 1000 persons/year). Among 0–17-year-olds, prescription rates across districts ranged from 312 to 1205 in 2010 and from 188 to 710 in 2018 per 1000 persons/year; among adults (≥18 years), they ranged from 388 to 841 in 2010 and from 300 to 693 in 2018 per 1000 persons/year. Despite the overall decline in outpatient antibiotic prescribing between 2010 and 2018, regional variations at the district level remained high in all age groups in Germany. Identifying reasons that explain the persistently high prescription rates in certain regions will be helpful in designing effective and tailored measures to further improve antibiotic stewardship in these regions.
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spelling pubmed-93121402022-07-26 Regional Variations in Outpatient Antibiotic Prescribing in Germany: A Small Area Analysis Based on Claims Data Scholle, Oliver Asendorf, Marieke Buck, Christoph Grill, Susann Jones, Christopher Kollhorst, Bianca Riedel, Oliver Schüz, Benjamin Haug, Ulrike Antibiotics (Basel) Article A comprehensive small area description of regional variations in outpatient antibiotic prescribing in Germany is lacking. Using the German Pharmacoepidemiological Research Database (GePaRD), a claims database covering ~20% of the German population, we determined the age- and sex-standardized prescription rates of antibiotics (number of outpatient prescriptions per 1000 persons/year). We calculated these prescription rates overall and on the level of 401 German districts for the calendar years 2010 and 2018. In 2018, the standardized prescription rate of antibiotics in the total study population was 23% lower than in 2010 (442 vs. 575 per 1000 persons/year). Among 0–17-year-olds, prescription rates across districts ranged from 312 to 1205 in 2010 and from 188 to 710 in 2018 per 1000 persons/year; among adults (≥18 years), they ranged from 388 to 841 in 2010 and from 300 to 693 in 2018 per 1000 persons/year. Despite the overall decline in outpatient antibiotic prescribing between 2010 and 2018, regional variations at the district level remained high in all age groups in Germany. Identifying reasons that explain the persistently high prescription rates in certain regions will be helpful in designing effective and tailored measures to further improve antibiotic stewardship in these regions. MDPI 2022-06-22 /pmc/articles/PMC9312140/ /pubmed/35884090 http://dx.doi.org/10.3390/antibiotics11070836 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Scholle, Oliver
Asendorf, Marieke
Buck, Christoph
Grill, Susann
Jones, Christopher
Kollhorst, Bianca
Riedel, Oliver
Schüz, Benjamin
Haug, Ulrike
Regional Variations in Outpatient Antibiotic Prescribing in Germany: A Small Area Analysis Based on Claims Data
title Regional Variations in Outpatient Antibiotic Prescribing in Germany: A Small Area Analysis Based on Claims Data
title_full Regional Variations in Outpatient Antibiotic Prescribing in Germany: A Small Area Analysis Based on Claims Data
title_fullStr Regional Variations in Outpatient Antibiotic Prescribing in Germany: A Small Area Analysis Based on Claims Data
title_full_unstemmed Regional Variations in Outpatient Antibiotic Prescribing in Germany: A Small Area Analysis Based on Claims Data
title_short Regional Variations in Outpatient Antibiotic Prescribing in Germany: A Small Area Analysis Based on Claims Data
title_sort regional variations in outpatient antibiotic prescribing in germany: a small area analysis based on claims data
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312140/
https://www.ncbi.nlm.nih.gov/pubmed/35884090
http://dx.doi.org/10.3390/antibiotics11070836
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