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Characterization of Pathway-Specific Regulator NigR for High Yield Production of Nigericin in Streptomyces malaysiensis F913

Nigericin is a polyether antibiotic with potent antibacterial, antifungal, antimalarial and anticancer activity. NigR, the only regulator in the nigericin biosynthetic gene cluster in Streptomyces malaysiensis F913, was identified as a SARP family regulator. Disruption of nigR abolished nigericin bi...

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Detalles Bibliográficos
Autores principales:	Wei, Junhong, Ma, Mengting, Guo, Senwen, Xu, Yaobo, Xie, Jie, Pan, Guoqing, Zhou, Zeyang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312159/ https://www.ncbi.nlm.nih.gov/pubmed/35884192 http://dx.doi.org/10.3390/antibiotics11070938

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