Activation of a Bacterial Mechanosensitive Channel, MscL, Underlies the Membrane Permeabilization of Dual-Targeting Antibacterial Compounds

Resistance to antibiotics is a serious and worsening threat to human health worldwide, and there is an urgent need to develop new antibiotics that can avert it. One possible solution is the development of compounds that possess multiple modes of action, requiring at least two mutations to acquire re...

Descripción completa

Detalles Bibliográficos
Autores principales: Wray, Robin, Wang, Junmei, Blount, Paul, Iscla, Irene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312261/
https://www.ncbi.nlm.nih.gov/pubmed/35884223
http://dx.doi.org/10.3390/antibiotics11070970

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312261/
https://www.ncbi.nlm.nih.gov/pubmed/35884223
http://dx.doi.org/10.3390/antibiotics11070970

Ejemplares similares