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Estimation of Redox Status in Military Pilots during Hypoxic Flight-Simulation Conditions—A Pilot Study

At high altitude conditions, the low-pressure atmospheric oxygen reduces the generation of energy, thus inducing a decrease in oxygen availability. As a result, endurance flights evoke imbalance in redox signaling, posing a safety risk for the pilots involved. The aim of the present study was to ass...

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Autores principales: Petraki, Konstantina, Grammatikopoulou, Maria G., Tekos, Fotios, Skaperda, Zoi, Orfanou, Marina, Mesnage, Robin, Vassilakou, Tonia, Kouretas, Demetrios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312332/
https://www.ncbi.nlm.nih.gov/pubmed/35883732
http://dx.doi.org/10.3390/antiox11071241
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author Petraki, Konstantina
Grammatikopoulou, Maria G.
Tekos, Fotios
Skaperda, Zoi
Orfanou, Marina
Mesnage, Robin
Vassilakou, Tonia
Kouretas, Demetrios
author_facet Petraki, Konstantina
Grammatikopoulou, Maria G.
Tekos, Fotios
Skaperda, Zoi
Orfanou, Marina
Mesnage, Robin
Vassilakou, Tonia
Kouretas, Demetrios
author_sort Petraki, Konstantina
collection PubMed
description At high altitude conditions, the low-pressure atmospheric oxygen reduces the generation of energy, thus inducing a decrease in oxygen availability. As a result, endurance flights evoke imbalance in redox signaling, posing a safety risk for the pilots involved. The aim of the present study was to assess changes in the redox status of military pilots during flight simulation conditions according to their flight hours (experts vs. novice). A total of seven expert pilots and an equal number of novice pilots (trainees) were recruited from the Center for Airforce Medicine of the Greek Military Airforce. Glutathione (GSH) levels, catalase activity (CAT), total antioxidant capacity (TAC), lipid peroxidation through the thiobarbituric acid-reactive substances (TBARS), and protein oxidative damage through the assay of protein carbonyls (PCs) levels were assessed at two time points, once prior to and once immediately post a scheduled flight simulation. In the experienced pilots’ arms, GSH was significantly increased post-flight simulation, with TAC being simultaneously reduced. On the other hand, in the trainees’ arms, CAT and TAC were both increased post-flight. No differences were noted with regard to the TBARS and PCs post-simulation. When the two groups were compared, TAC and PCs were significantly lower in the trainees compared to the experienced pilots. The present study provides useful insight into the physiological redox status adaptations to hypobaric hypoxic flight conditions among pilots. In a further detail, an increase in GSH response post-flight simulation is being evoked in more experienced pilots, indicating an adaptation to the extreme flight conditions, as they battle oxidative stress.
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spelling pubmed-93123322022-07-26 Estimation of Redox Status in Military Pilots during Hypoxic Flight-Simulation Conditions—A Pilot Study Petraki, Konstantina Grammatikopoulou, Maria G. Tekos, Fotios Skaperda, Zoi Orfanou, Marina Mesnage, Robin Vassilakou, Tonia Kouretas, Demetrios Antioxidants (Basel) Article At high altitude conditions, the low-pressure atmospheric oxygen reduces the generation of energy, thus inducing a decrease in oxygen availability. As a result, endurance flights evoke imbalance in redox signaling, posing a safety risk for the pilots involved. The aim of the present study was to assess changes in the redox status of military pilots during flight simulation conditions according to their flight hours (experts vs. novice). A total of seven expert pilots and an equal number of novice pilots (trainees) were recruited from the Center for Airforce Medicine of the Greek Military Airforce. Glutathione (GSH) levels, catalase activity (CAT), total antioxidant capacity (TAC), lipid peroxidation through the thiobarbituric acid-reactive substances (TBARS), and protein oxidative damage through the assay of protein carbonyls (PCs) levels were assessed at two time points, once prior to and once immediately post a scheduled flight simulation. In the experienced pilots’ arms, GSH was significantly increased post-flight simulation, with TAC being simultaneously reduced. On the other hand, in the trainees’ arms, CAT and TAC were both increased post-flight. No differences were noted with regard to the TBARS and PCs post-simulation. When the two groups were compared, TAC and PCs were significantly lower in the trainees compared to the experienced pilots. The present study provides useful insight into the physiological redox status adaptations to hypobaric hypoxic flight conditions among pilots. In a further detail, an increase in GSH response post-flight simulation is being evoked in more experienced pilots, indicating an adaptation to the extreme flight conditions, as they battle oxidative stress. MDPI 2022-06-24 /pmc/articles/PMC9312332/ /pubmed/35883732 http://dx.doi.org/10.3390/antiox11071241 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Petraki, Konstantina
Grammatikopoulou, Maria G.
Tekos, Fotios
Skaperda, Zoi
Orfanou, Marina
Mesnage, Robin
Vassilakou, Tonia
Kouretas, Demetrios
Estimation of Redox Status in Military Pilots during Hypoxic Flight-Simulation Conditions—A Pilot Study
title Estimation of Redox Status in Military Pilots during Hypoxic Flight-Simulation Conditions—A Pilot Study
title_full Estimation of Redox Status in Military Pilots during Hypoxic Flight-Simulation Conditions—A Pilot Study
title_fullStr Estimation of Redox Status in Military Pilots during Hypoxic Flight-Simulation Conditions—A Pilot Study
title_full_unstemmed Estimation of Redox Status in Military Pilots during Hypoxic Flight-Simulation Conditions—A Pilot Study
title_short Estimation of Redox Status in Military Pilots during Hypoxic Flight-Simulation Conditions—A Pilot Study
title_sort estimation of redox status in military pilots during hypoxic flight-simulation conditions—a pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312332/
https://www.ncbi.nlm.nih.gov/pubmed/35883732
http://dx.doi.org/10.3390/antiox11071241
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