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Ambivalent Roles of Oxidative Stress in Triangular Relationships among Arthropod Vectors, Pathogens and Hosts
Blood-feeding arthropods, particularly ticks and mosquitoes are considered the most important vectors of arthropod-borne diseases affecting humans and animals. While feeding on blood meals, arthropods are exposed to high levels of reactive oxygen species (ROS) since heme and other blood components c...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312350/ https://www.ncbi.nlm.nih.gov/pubmed/35883744 http://dx.doi.org/10.3390/antiox11071254 |
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author | Hernandez, Emmanuel Pacia Anisuzzaman, Alim, Md Abdul Kawada, Hayato Kwofie, Kofi Dadzie Ladzekpo, Danielle Koike, Yuki Inoue, Takahiro Sasaki, Sana Mikami, Fusako Matsubayashi, Makoto Tanaka, Tetsuya Tsuji, Naotoshi Hatta, Takeshi |
author_facet | Hernandez, Emmanuel Pacia Anisuzzaman, Alim, Md Abdul Kawada, Hayato Kwofie, Kofi Dadzie Ladzekpo, Danielle Koike, Yuki Inoue, Takahiro Sasaki, Sana Mikami, Fusako Matsubayashi, Makoto Tanaka, Tetsuya Tsuji, Naotoshi Hatta, Takeshi |
author_sort | Hernandez, Emmanuel Pacia |
collection | PubMed |
description | Blood-feeding arthropods, particularly ticks and mosquitoes are considered the most important vectors of arthropod-borne diseases affecting humans and animals. While feeding on blood meals, arthropods are exposed to high levels of reactive oxygen species (ROS) since heme and other blood components can induce oxidative stress. Different ROS have important roles in interactions among the pathogens, vectors, and hosts. ROS influence various metabolic processes of the arthropods and some have detrimental effects. In this review, we investigate the various roles of ROS in these arthropods, including their innate immunity and the homeostasis of their microbiomes, that is, how ROS are utilized to maintain the balance between the natural microbiota and potential pathogens. We elucidate the mechanism of how ROS are utilized to fight off invading pathogens and how the arthropod-borne pathogens use the arthropods’ antioxidant mechanism to defend against these ROS attacks and their possible impact on their vector potentials or their ability to acquire and transmit pathogens. In addition, we describe the possible roles of ROS in chemical insecticide/acaricide activity and/or in the development of resistance. Overall, this underscores the importance of the antioxidant system as a potential target for the control of arthropod and arthropod-borne pathogens. |
format | Online Article Text |
id | pubmed-9312350 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93123502022-07-26 Ambivalent Roles of Oxidative Stress in Triangular Relationships among Arthropod Vectors, Pathogens and Hosts Hernandez, Emmanuel Pacia Anisuzzaman, Alim, Md Abdul Kawada, Hayato Kwofie, Kofi Dadzie Ladzekpo, Danielle Koike, Yuki Inoue, Takahiro Sasaki, Sana Mikami, Fusako Matsubayashi, Makoto Tanaka, Tetsuya Tsuji, Naotoshi Hatta, Takeshi Antioxidants (Basel) Review Blood-feeding arthropods, particularly ticks and mosquitoes are considered the most important vectors of arthropod-borne diseases affecting humans and animals. While feeding on blood meals, arthropods are exposed to high levels of reactive oxygen species (ROS) since heme and other blood components can induce oxidative stress. Different ROS have important roles in interactions among the pathogens, vectors, and hosts. ROS influence various metabolic processes of the arthropods and some have detrimental effects. In this review, we investigate the various roles of ROS in these arthropods, including their innate immunity and the homeostasis of their microbiomes, that is, how ROS are utilized to maintain the balance between the natural microbiota and potential pathogens. We elucidate the mechanism of how ROS are utilized to fight off invading pathogens and how the arthropod-borne pathogens use the arthropods’ antioxidant mechanism to defend against these ROS attacks and their possible impact on their vector potentials or their ability to acquire and transmit pathogens. In addition, we describe the possible roles of ROS in chemical insecticide/acaricide activity and/or in the development of resistance. Overall, this underscores the importance of the antioxidant system as a potential target for the control of arthropod and arthropod-borne pathogens. MDPI 2022-06-25 /pmc/articles/PMC9312350/ /pubmed/35883744 http://dx.doi.org/10.3390/antiox11071254 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hernandez, Emmanuel Pacia Anisuzzaman, Alim, Md Abdul Kawada, Hayato Kwofie, Kofi Dadzie Ladzekpo, Danielle Koike, Yuki Inoue, Takahiro Sasaki, Sana Mikami, Fusako Matsubayashi, Makoto Tanaka, Tetsuya Tsuji, Naotoshi Hatta, Takeshi Ambivalent Roles of Oxidative Stress in Triangular Relationships among Arthropod Vectors, Pathogens and Hosts |
title | Ambivalent Roles of Oxidative Stress in Triangular Relationships among Arthropod Vectors, Pathogens and Hosts |
title_full | Ambivalent Roles of Oxidative Stress in Triangular Relationships among Arthropod Vectors, Pathogens and Hosts |
title_fullStr | Ambivalent Roles of Oxidative Stress in Triangular Relationships among Arthropod Vectors, Pathogens and Hosts |
title_full_unstemmed | Ambivalent Roles of Oxidative Stress in Triangular Relationships among Arthropod Vectors, Pathogens and Hosts |
title_short | Ambivalent Roles of Oxidative Stress in Triangular Relationships among Arthropod Vectors, Pathogens and Hosts |
title_sort | ambivalent roles of oxidative stress in triangular relationships among arthropod vectors, pathogens and hosts |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312350/ https://www.ncbi.nlm.nih.gov/pubmed/35883744 http://dx.doi.org/10.3390/antiox11071254 |
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