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Ambivalent Roles of Oxidative Stress in Triangular Relationships among Arthropod Vectors, Pathogens and Hosts

Blood-feeding arthropods, particularly ticks and mosquitoes are considered the most important vectors of arthropod-borne diseases affecting humans and animals. While feeding on blood meals, arthropods are exposed to high levels of reactive oxygen species (ROS) since heme and other blood components c...

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Autores principales: Hernandez, Emmanuel Pacia, Anisuzzaman, Alim, Md Abdul, Kawada, Hayato, Kwofie, Kofi Dadzie, Ladzekpo, Danielle, Koike, Yuki, Inoue, Takahiro, Sasaki, Sana, Mikami, Fusako, Matsubayashi, Makoto, Tanaka, Tetsuya, Tsuji, Naotoshi, Hatta, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312350/
https://www.ncbi.nlm.nih.gov/pubmed/35883744
http://dx.doi.org/10.3390/antiox11071254
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author Hernandez, Emmanuel Pacia
Anisuzzaman,
Alim, Md Abdul
Kawada, Hayato
Kwofie, Kofi Dadzie
Ladzekpo, Danielle
Koike, Yuki
Inoue, Takahiro
Sasaki, Sana
Mikami, Fusako
Matsubayashi, Makoto
Tanaka, Tetsuya
Tsuji, Naotoshi
Hatta, Takeshi
author_facet Hernandez, Emmanuel Pacia
Anisuzzaman,
Alim, Md Abdul
Kawada, Hayato
Kwofie, Kofi Dadzie
Ladzekpo, Danielle
Koike, Yuki
Inoue, Takahiro
Sasaki, Sana
Mikami, Fusako
Matsubayashi, Makoto
Tanaka, Tetsuya
Tsuji, Naotoshi
Hatta, Takeshi
author_sort Hernandez, Emmanuel Pacia
collection PubMed
description Blood-feeding arthropods, particularly ticks and mosquitoes are considered the most important vectors of arthropod-borne diseases affecting humans and animals. While feeding on blood meals, arthropods are exposed to high levels of reactive oxygen species (ROS) since heme and other blood components can induce oxidative stress. Different ROS have important roles in interactions among the pathogens, vectors, and hosts. ROS influence various metabolic processes of the arthropods and some have detrimental effects. In this review, we investigate the various roles of ROS in these arthropods, including their innate immunity and the homeostasis of their microbiomes, that is, how ROS are utilized to maintain the balance between the natural microbiota and potential pathogens. We elucidate the mechanism of how ROS are utilized to fight off invading pathogens and how the arthropod-borne pathogens use the arthropods’ antioxidant mechanism to defend against these ROS attacks and their possible impact on their vector potentials or their ability to acquire and transmit pathogens. In addition, we describe the possible roles of ROS in chemical insecticide/acaricide activity and/or in the development of resistance. Overall, this underscores the importance of the antioxidant system as a potential target for the control of arthropod and arthropod-borne pathogens.
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spelling pubmed-93123502022-07-26 Ambivalent Roles of Oxidative Stress in Triangular Relationships among Arthropod Vectors, Pathogens and Hosts Hernandez, Emmanuel Pacia Anisuzzaman, Alim, Md Abdul Kawada, Hayato Kwofie, Kofi Dadzie Ladzekpo, Danielle Koike, Yuki Inoue, Takahiro Sasaki, Sana Mikami, Fusako Matsubayashi, Makoto Tanaka, Tetsuya Tsuji, Naotoshi Hatta, Takeshi Antioxidants (Basel) Review Blood-feeding arthropods, particularly ticks and mosquitoes are considered the most important vectors of arthropod-borne diseases affecting humans and animals. While feeding on blood meals, arthropods are exposed to high levels of reactive oxygen species (ROS) since heme and other blood components can induce oxidative stress. Different ROS have important roles in interactions among the pathogens, vectors, and hosts. ROS influence various metabolic processes of the arthropods and some have detrimental effects. In this review, we investigate the various roles of ROS in these arthropods, including their innate immunity and the homeostasis of their microbiomes, that is, how ROS are utilized to maintain the balance between the natural microbiota and potential pathogens. We elucidate the mechanism of how ROS are utilized to fight off invading pathogens and how the arthropod-borne pathogens use the arthropods’ antioxidant mechanism to defend against these ROS attacks and their possible impact on their vector potentials or their ability to acquire and transmit pathogens. In addition, we describe the possible roles of ROS in chemical insecticide/acaricide activity and/or in the development of resistance. Overall, this underscores the importance of the antioxidant system as a potential target for the control of arthropod and arthropod-borne pathogens. MDPI 2022-06-25 /pmc/articles/PMC9312350/ /pubmed/35883744 http://dx.doi.org/10.3390/antiox11071254 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hernandez, Emmanuel Pacia
Anisuzzaman,
Alim, Md Abdul
Kawada, Hayato
Kwofie, Kofi Dadzie
Ladzekpo, Danielle
Koike, Yuki
Inoue, Takahiro
Sasaki, Sana
Mikami, Fusako
Matsubayashi, Makoto
Tanaka, Tetsuya
Tsuji, Naotoshi
Hatta, Takeshi
Ambivalent Roles of Oxidative Stress in Triangular Relationships among Arthropod Vectors, Pathogens and Hosts
title Ambivalent Roles of Oxidative Stress in Triangular Relationships among Arthropod Vectors, Pathogens and Hosts
title_full Ambivalent Roles of Oxidative Stress in Triangular Relationships among Arthropod Vectors, Pathogens and Hosts
title_fullStr Ambivalent Roles of Oxidative Stress in Triangular Relationships among Arthropod Vectors, Pathogens and Hosts
title_full_unstemmed Ambivalent Roles of Oxidative Stress in Triangular Relationships among Arthropod Vectors, Pathogens and Hosts
title_short Ambivalent Roles of Oxidative Stress in Triangular Relationships among Arthropod Vectors, Pathogens and Hosts
title_sort ambivalent roles of oxidative stress in triangular relationships among arthropod vectors, pathogens and hosts
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312350/
https://www.ncbi.nlm.nih.gov/pubmed/35883744
http://dx.doi.org/10.3390/antiox11071254
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