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Getting Closer to Decrypting the Phase Transitions of Bacterial Biomolecules
Liquid–liquid phase separation (LLPS) of biomolecules has emerged as a new paradigm in cell biology, and the process is one proposed mechanism for the formation of membraneless organelles (MLOs). Bacterial cells have only recently drawn strong interest in terms of studies on both liquid-to-liquid an...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312465/ https://www.ncbi.nlm.nih.gov/pubmed/35883463 http://dx.doi.org/10.3390/biom12070907 |
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author | Sołtys, Katarzyna Tarczewska, Aneta Bystranowska, Dominika Sozańska, Nikola |
author_facet | Sołtys, Katarzyna Tarczewska, Aneta Bystranowska, Dominika Sozańska, Nikola |
author_sort | Sołtys, Katarzyna |
collection | PubMed |
description | Liquid–liquid phase separation (LLPS) of biomolecules has emerged as a new paradigm in cell biology, and the process is one proposed mechanism for the formation of membraneless organelles (MLOs). Bacterial cells have only recently drawn strong interest in terms of studies on both liquid-to-liquid and liquid-to-solid phase transitions. It seems that these processes drive the formation of prokaryotic cellular condensates that resemble eukaryotic MLOs. In this review, we present an overview of the key microbial biomolecules that undergo LLPS, as well as the formation and organization of biomacromolecular condensates within the intracellular space. We also discuss the current challenges in investigating bacterial biomacromolecular condensates. Additionally, we highlight a summary of recent knowledge about the participation of bacterial biomolecules in a phase transition and provide some new in silico analyses that can be helpful for further investigations. |
format | Online Article Text |
id | pubmed-9312465 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93124652022-07-26 Getting Closer to Decrypting the Phase Transitions of Bacterial Biomolecules Sołtys, Katarzyna Tarczewska, Aneta Bystranowska, Dominika Sozańska, Nikola Biomolecules Review Liquid–liquid phase separation (LLPS) of biomolecules has emerged as a new paradigm in cell biology, and the process is one proposed mechanism for the formation of membraneless organelles (MLOs). Bacterial cells have only recently drawn strong interest in terms of studies on both liquid-to-liquid and liquid-to-solid phase transitions. It seems that these processes drive the formation of prokaryotic cellular condensates that resemble eukaryotic MLOs. In this review, we present an overview of the key microbial biomolecules that undergo LLPS, as well as the formation and organization of biomacromolecular condensates within the intracellular space. We also discuss the current challenges in investigating bacterial biomacromolecular condensates. Additionally, we highlight a summary of recent knowledge about the participation of bacterial biomolecules in a phase transition and provide some new in silico analyses that can be helpful for further investigations. MDPI 2022-06-28 /pmc/articles/PMC9312465/ /pubmed/35883463 http://dx.doi.org/10.3390/biom12070907 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sołtys, Katarzyna Tarczewska, Aneta Bystranowska, Dominika Sozańska, Nikola Getting Closer to Decrypting the Phase Transitions of Bacterial Biomolecules |
title | Getting Closer to Decrypting the Phase Transitions of Bacterial Biomolecules |
title_full | Getting Closer to Decrypting the Phase Transitions of Bacterial Biomolecules |
title_fullStr | Getting Closer to Decrypting the Phase Transitions of Bacterial Biomolecules |
title_full_unstemmed | Getting Closer to Decrypting the Phase Transitions of Bacterial Biomolecules |
title_short | Getting Closer to Decrypting the Phase Transitions of Bacterial Biomolecules |
title_sort | getting closer to decrypting the phase transitions of bacterial biomolecules |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312465/ https://www.ncbi.nlm.nih.gov/pubmed/35883463 http://dx.doi.org/10.3390/biom12070907 |
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