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The Role of Mitochondrial Metabolism, AMPK-SIRT Mediated Pathway, LncRNA and MicroRNA in Osteoarthritis

Osteoarthritis (OA) is the most common joint disease characterized by degeneration of articular cartilage and causes severe joint pain, physical disability, and impaired quality of life. Recently, it was found that mitochondria not only act as a powerhouse of cells that provide energy for cellular m...

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Autores principales: Liu, Hao-Yu, Chang, Chi-Fen, Lu, Cheng-Chang, Wu, Shun-Cheng, Huang, Bin, Cheng, Tsung-Lin, Lin, Sung-Yen, Ho, Cheng-Jung, Lee, Mon-Juan, Yang, Chung-Da, Wang, Ying-Chun, Li, Jhong-You, Liu, Ping-Cheng, Wei, Chun-Wang, Kang, Lin, Chen, Chung-Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312479/
https://www.ncbi.nlm.nih.gov/pubmed/35884782
http://dx.doi.org/10.3390/biomedicines10071477
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author Liu, Hao-Yu
Chang, Chi-Fen
Lu, Cheng-Chang
Wu, Shun-Cheng
Huang, Bin
Cheng, Tsung-Lin
Lin, Sung-Yen
Ho, Cheng-Jung
Lee, Mon-Juan
Yang, Chung-Da
Wang, Ying-Chun
Li, Jhong-You
Liu, Ping-Cheng
Wei, Chun-Wang
Kang, Lin
Chen, Chung-Hwan
author_facet Liu, Hao-Yu
Chang, Chi-Fen
Lu, Cheng-Chang
Wu, Shun-Cheng
Huang, Bin
Cheng, Tsung-Lin
Lin, Sung-Yen
Ho, Cheng-Jung
Lee, Mon-Juan
Yang, Chung-Da
Wang, Ying-Chun
Li, Jhong-You
Liu, Ping-Cheng
Wei, Chun-Wang
Kang, Lin
Chen, Chung-Hwan
author_sort Liu, Hao-Yu
collection PubMed
description Osteoarthritis (OA) is the most common joint disease characterized by degeneration of articular cartilage and causes severe joint pain, physical disability, and impaired quality of life. Recently, it was found that mitochondria not only act as a powerhouse of cells that provide energy for cellular metabolism, but are also involved in crucial pathways responsible for maintaining chondrocyte physiology. Therefore, a growing amount of evidence emphasizes that impairment of mitochondrial function is associated with OA pathogenesis; however, the exact mechanism is not well known. Moreover, the AMP-activated protein kinase (AMPK)–Sirtuin (SIRT) signaling pathway, long non-coding RNA (lncRNA), and microRNA (miRNA) are important for regulating the physiological and pathological processes of chondrocytes, indicating that these may be targets for OA treatment. In this review, we first focus on the importance of mitochondria metabolic dysregulation related to OA. Then, we show recent evidence on the AMPK-SIRT mediated pathway associated with OA pathogenesis and potential treatment options. Finally, we discuss current research into the effects of lncRNA and miRNA on OA progression or inhibition.
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spelling pubmed-93124792022-07-26 The Role of Mitochondrial Metabolism, AMPK-SIRT Mediated Pathway, LncRNA and MicroRNA in Osteoarthritis Liu, Hao-Yu Chang, Chi-Fen Lu, Cheng-Chang Wu, Shun-Cheng Huang, Bin Cheng, Tsung-Lin Lin, Sung-Yen Ho, Cheng-Jung Lee, Mon-Juan Yang, Chung-Da Wang, Ying-Chun Li, Jhong-You Liu, Ping-Cheng Wei, Chun-Wang Kang, Lin Chen, Chung-Hwan Biomedicines Review Osteoarthritis (OA) is the most common joint disease characterized by degeneration of articular cartilage and causes severe joint pain, physical disability, and impaired quality of life. Recently, it was found that mitochondria not only act as a powerhouse of cells that provide energy for cellular metabolism, but are also involved in crucial pathways responsible for maintaining chondrocyte physiology. Therefore, a growing amount of evidence emphasizes that impairment of mitochondrial function is associated with OA pathogenesis; however, the exact mechanism is not well known. Moreover, the AMP-activated protein kinase (AMPK)–Sirtuin (SIRT) signaling pathway, long non-coding RNA (lncRNA), and microRNA (miRNA) are important for regulating the physiological and pathological processes of chondrocytes, indicating that these may be targets for OA treatment. In this review, we first focus on the importance of mitochondria metabolic dysregulation related to OA. Then, we show recent evidence on the AMPK-SIRT mediated pathway associated with OA pathogenesis and potential treatment options. Finally, we discuss current research into the effects of lncRNA and miRNA on OA progression or inhibition. MDPI 2022-06-22 /pmc/articles/PMC9312479/ /pubmed/35884782 http://dx.doi.org/10.3390/biomedicines10071477 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Liu, Hao-Yu
Chang, Chi-Fen
Lu, Cheng-Chang
Wu, Shun-Cheng
Huang, Bin
Cheng, Tsung-Lin
Lin, Sung-Yen
Ho, Cheng-Jung
Lee, Mon-Juan
Yang, Chung-Da
Wang, Ying-Chun
Li, Jhong-You
Liu, Ping-Cheng
Wei, Chun-Wang
Kang, Lin
Chen, Chung-Hwan
The Role of Mitochondrial Metabolism, AMPK-SIRT Mediated Pathway, LncRNA and MicroRNA in Osteoarthritis
title The Role of Mitochondrial Metabolism, AMPK-SIRT Mediated Pathway, LncRNA and MicroRNA in Osteoarthritis
title_full The Role of Mitochondrial Metabolism, AMPK-SIRT Mediated Pathway, LncRNA and MicroRNA in Osteoarthritis
title_fullStr The Role of Mitochondrial Metabolism, AMPK-SIRT Mediated Pathway, LncRNA and MicroRNA in Osteoarthritis
title_full_unstemmed The Role of Mitochondrial Metabolism, AMPK-SIRT Mediated Pathway, LncRNA and MicroRNA in Osteoarthritis
title_short The Role of Mitochondrial Metabolism, AMPK-SIRT Mediated Pathway, LncRNA and MicroRNA in Osteoarthritis
title_sort role of mitochondrial metabolism, ampk-sirt mediated pathway, lncrna and microrna in osteoarthritis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312479/
https://www.ncbi.nlm.nih.gov/pubmed/35884782
http://dx.doi.org/10.3390/biomedicines10071477
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