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Chemical Barrier Proteins in Human Body Fluids

Chemical barriers are composed of those sites of the human body where potential pathogens can contact the host cells. A chemical barrier is made up by different proteins that are part of the antimicrobial and immunomodulatory protein/peptide (AMP) family. Proteins of the AMP family exert antibacteri...

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Autores principales: Kalló, Gergő, Kumar, Ajneesh, Tőzsér, József, Csősz, Éva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312486/
https://www.ncbi.nlm.nih.gov/pubmed/35884778
http://dx.doi.org/10.3390/biomedicines10071472
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author Kalló, Gergő
Kumar, Ajneesh
Tőzsér, József
Csősz, Éva
author_facet Kalló, Gergő
Kumar, Ajneesh
Tőzsér, József
Csősz, Éva
author_sort Kalló, Gergő
collection PubMed
description Chemical barriers are composed of those sites of the human body where potential pathogens can contact the host cells. A chemical barrier is made up by different proteins that are part of the antimicrobial and immunomodulatory protein/peptide (AMP) family. Proteins of the AMP family exert antibacterial, antiviral, and/or antifungal activity and can modulate the immune system. Besides these proteins, a wide range of proteases and protease inhibitors can also be found in the chemical barriers maintaining a proteolytic balance in the host and/or the pathogens. In this review, we aimed to identify the chemical barrier components in nine human body fluids. The interaction networks of the chemical barrier proteins in each examined body fluid were generated as well.
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spelling pubmed-93124862022-07-26 Chemical Barrier Proteins in Human Body Fluids Kalló, Gergő Kumar, Ajneesh Tőzsér, József Csősz, Éva Biomedicines Review Chemical barriers are composed of those sites of the human body where potential pathogens can contact the host cells. A chemical barrier is made up by different proteins that are part of the antimicrobial and immunomodulatory protein/peptide (AMP) family. Proteins of the AMP family exert antibacterial, antiviral, and/or antifungal activity and can modulate the immune system. Besides these proteins, a wide range of proteases and protease inhibitors can also be found in the chemical barriers maintaining a proteolytic balance in the host and/or the pathogens. In this review, we aimed to identify the chemical barrier components in nine human body fluids. The interaction networks of the chemical barrier proteins in each examined body fluid were generated as well. MDPI 2022-06-22 /pmc/articles/PMC9312486/ /pubmed/35884778 http://dx.doi.org/10.3390/biomedicines10071472 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kalló, Gergő
Kumar, Ajneesh
Tőzsér, József
Csősz, Éva
Chemical Barrier Proteins in Human Body Fluids
title Chemical Barrier Proteins in Human Body Fluids
title_full Chemical Barrier Proteins in Human Body Fluids
title_fullStr Chemical Barrier Proteins in Human Body Fluids
title_full_unstemmed Chemical Barrier Proteins in Human Body Fluids
title_short Chemical Barrier Proteins in Human Body Fluids
title_sort chemical barrier proteins in human body fluids
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312486/
https://www.ncbi.nlm.nih.gov/pubmed/35884778
http://dx.doi.org/10.3390/biomedicines10071472
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