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Usefulness of the Measurement of Serum Paraoxonase-1 Arylesterase Activity in the Diagnoses of COVID-19
The development of inexpensive, fast, and reliable screening tests for COVID-19 is, as yet, an unmet need. The present study was aimed at evaluating the usefulness of serum arylesterase activity of paraoxonase-1 (PON1) measurement as a screening test in patients with different severity levels of COV...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312761/ https://www.ncbi.nlm.nih.gov/pubmed/35883435 http://dx.doi.org/10.3390/biom12070879 |
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author | Gabaldó, Xavier Juanpere, Màrius Castañé, Helena Rodríguez-Tomàs, Elisabet López-Azcona, Ana Felisa Baiges-Gaya, Gerard Castro, Lourdes Valverde-Díaz, Enrique Muñoz-Blázquez, Aida Giménez-Cuenca, Laura Felipo-Balada, Laura Ballester, Frederic Pujol, Isabel Simó, Josep M. Castro, Antoni Iftimie, Simona Camps, Jordi Joven, Jorge |
author_facet | Gabaldó, Xavier Juanpere, Màrius Castañé, Helena Rodríguez-Tomàs, Elisabet López-Azcona, Ana Felisa Baiges-Gaya, Gerard Castro, Lourdes Valverde-Díaz, Enrique Muñoz-Blázquez, Aida Giménez-Cuenca, Laura Felipo-Balada, Laura Ballester, Frederic Pujol, Isabel Simó, Josep M. Castro, Antoni Iftimie, Simona Camps, Jordi Joven, Jorge |
author_sort | Gabaldó, Xavier |
collection | PubMed |
description | The development of inexpensive, fast, and reliable screening tests for COVID-19 is, as yet, an unmet need. The present study was aimed at evaluating the usefulness of serum arylesterase activity of paraoxonase-1 (PON1) measurement as a screening test in patients with different severity levels of COVID-19 infection. We included 615 COVID-19-positive patients who were classified as asymptomatic, mildly symptomatic, severely symptomatic, or fatally symptomatic. Results were compared with 50 healthy volunteers, 330 patients with cancer, and 343 with morbid obesity. Results showed PON1 activity greatly decreased in COVID-19 compared to healthy volunteers; a receiver operating characteristics plot showed a high diagnostic accuracy. The degree of COVID-19 severity did not influence PON1 levels. Our results indicated that PON1 determination was efficient for disease diagnosis, but not for prognosis. Furthermore, patients with obesity or cancer presented alterations similar to those of COVID-19 patients. As such, elevated levels of PON1 indicate the absence of COVID-19, but low levels may be present in various other chronic diseases. The assay is fast and inexpensive. We suggest that PON1 measurement could be used as an initial, high cut-off point screening method, while lower values should be confirmed with the more expensive nucleic acid amplification test. |
format | Online Article Text |
id | pubmed-9312761 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93127612022-07-26 Usefulness of the Measurement of Serum Paraoxonase-1 Arylesterase Activity in the Diagnoses of COVID-19 Gabaldó, Xavier Juanpere, Màrius Castañé, Helena Rodríguez-Tomàs, Elisabet López-Azcona, Ana Felisa Baiges-Gaya, Gerard Castro, Lourdes Valverde-Díaz, Enrique Muñoz-Blázquez, Aida Giménez-Cuenca, Laura Felipo-Balada, Laura Ballester, Frederic Pujol, Isabel Simó, Josep M. Castro, Antoni Iftimie, Simona Camps, Jordi Joven, Jorge Biomolecules Article The development of inexpensive, fast, and reliable screening tests for COVID-19 is, as yet, an unmet need. The present study was aimed at evaluating the usefulness of serum arylesterase activity of paraoxonase-1 (PON1) measurement as a screening test in patients with different severity levels of COVID-19 infection. We included 615 COVID-19-positive patients who were classified as asymptomatic, mildly symptomatic, severely symptomatic, or fatally symptomatic. Results were compared with 50 healthy volunteers, 330 patients with cancer, and 343 with morbid obesity. Results showed PON1 activity greatly decreased in COVID-19 compared to healthy volunteers; a receiver operating characteristics plot showed a high diagnostic accuracy. The degree of COVID-19 severity did not influence PON1 levels. Our results indicated that PON1 determination was efficient for disease diagnosis, but not for prognosis. Furthermore, patients with obesity or cancer presented alterations similar to those of COVID-19 patients. As such, elevated levels of PON1 indicate the absence of COVID-19, but low levels may be present in various other chronic diseases. The assay is fast and inexpensive. We suggest that PON1 measurement could be used as an initial, high cut-off point screening method, while lower values should be confirmed with the more expensive nucleic acid amplification test. MDPI 2022-06-23 /pmc/articles/PMC9312761/ /pubmed/35883435 http://dx.doi.org/10.3390/biom12070879 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Gabaldó, Xavier Juanpere, Màrius Castañé, Helena Rodríguez-Tomàs, Elisabet López-Azcona, Ana Felisa Baiges-Gaya, Gerard Castro, Lourdes Valverde-Díaz, Enrique Muñoz-Blázquez, Aida Giménez-Cuenca, Laura Felipo-Balada, Laura Ballester, Frederic Pujol, Isabel Simó, Josep M. Castro, Antoni Iftimie, Simona Camps, Jordi Joven, Jorge Usefulness of the Measurement of Serum Paraoxonase-1 Arylesterase Activity in the Diagnoses of COVID-19 |
title | Usefulness of the Measurement of Serum Paraoxonase-1 Arylesterase Activity in the Diagnoses of COVID-19 |
title_full | Usefulness of the Measurement of Serum Paraoxonase-1 Arylesterase Activity in the Diagnoses of COVID-19 |
title_fullStr | Usefulness of the Measurement of Serum Paraoxonase-1 Arylesterase Activity in the Diagnoses of COVID-19 |
title_full_unstemmed | Usefulness of the Measurement of Serum Paraoxonase-1 Arylesterase Activity in the Diagnoses of COVID-19 |
title_short | Usefulness of the Measurement of Serum Paraoxonase-1 Arylesterase Activity in the Diagnoses of COVID-19 |
title_sort | usefulness of the measurement of serum paraoxonase-1 arylesterase activity in the diagnoses of covid-19 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312761/ https://www.ncbi.nlm.nih.gov/pubmed/35883435 http://dx.doi.org/10.3390/biom12070879 |
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