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Usefulness of the Measurement of Serum Paraoxonase-1 Arylesterase Activity in the Diagnoses of COVID-19

The development of inexpensive, fast, and reliable screening tests for COVID-19 is, as yet, an unmet need. The present study was aimed at evaluating the usefulness of serum arylesterase activity of paraoxonase-1 (PON1) measurement as a screening test in patients with different severity levels of COV...

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Autores principales: Gabaldó, Xavier, Juanpere, Màrius, Castañé, Helena, Rodríguez-Tomàs, Elisabet, López-Azcona, Ana Felisa, Baiges-Gaya, Gerard, Castro, Lourdes, Valverde-Díaz, Enrique, Muñoz-Blázquez, Aida, Giménez-Cuenca, Laura, Felipo-Balada, Laura, Ballester, Frederic, Pujol, Isabel, Simó, Josep M., Castro, Antoni, Iftimie, Simona, Camps, Jordi, Joven, Jorge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312761/
https://www.ncbi.nlm.nih.gov/pubmed/35883435
http://dx.doi.org/10.3390/biom12070879
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author Gabaldó, Xavier
Juanpere, Màrius
Castañé, Helena
Rodríguez-Tomàs, Elisabet
López-Azcona, Ana Felisa
Baiges-Gaya, Gerard
Castro, Lourdes
Valverde-Díaz, Enrique
Muñoz-Blázquez, Aida
Giménez-Cuenca, Laura
Felipo-Balada, Laura
Ballester, Frederic
Pujol, Isabel
Simó, Josep M.
Castro, Antoni
Iftimie, Simona
Camps, Jordi
Joven, Jorge
author_facet Gabaldó, Xavier
Juanpere, Màrius
Castañé, Helena
Rodríguez-Tomàs, Elisabet
López-Azcona, Ana Felisa
Baiges-Gaya, Gerard
Castro, Lourdes
Valverde-Díaz, Enrique
Muñoz-Blázquez, Aida
Giménez-Cuenca, Laura
Felipo-Balada, Laura
Ballester, Frederic
Pujol, Isabel
Simó, Josep M.
Castro, Antoni
Iftimie, Simona
Camps, Jordi
Joven, Jorge
author_sort Gabaldó, Xavier
collection PubMed
description The development of inexpensive, fast, and reliable screening tests for COVID-19 is, as yet, an unmet need. The present study was aimed at evaluating the usefulness of serum arylesterase activity of paraoxonase-1 (PON1) measurement as a screening test in patients with different severity levels of COVID-19 infection. We included 615 COVID-19-positive patients who were classified as asymptomatic, mildly symptomatic, severely symptomatic, or fatally symptomatic. Results were compared with 50 healthy volunteers, 330 patients with cancer, and 343 with morbid obesity. Results showed PON1 activity greatly decreased in COVID-19 compared to healthy volunteers; a receiver operating characteristics plot showed a high diagnostic accuracy. The degree of COVID-19 severity did not influence PON1 levels. Our results indicated that PON1 determination was efficient for disease diagnosis, but not for prognosis. Furthermore, patients with obesity or cancer presented alterations similar to those of COVID-19 patients. As such, elevated levels of PON1 indicate the absence of COVID-19, but low levels may be present in various other chronic diseases. The assay is fast and inexpensive. We suggest that PON1 measurement could be used as an initial, high cut-off point screening method, while lower values should be confirmed with the more expensive nucleic acid amplification test.
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spelling pubmed-93127612022-07-26 Usefulness of the Measurement of Serum Paraoxonase-1 Arylesterase Activity in the Diagnoses of COVID-19 Gabaldó, Xavier Juanpere, Màrius Castañé, Helena Rodríguez-Tomàs, Elisabet López-Azcona, Ana Felisa Baiges-Gaya, Gerard Castro, Lourdes Valverde-Díaz, Enrique Muñoz-Blázquez, Aida Giménez-Cuenca, Laura Felipo-Balada, Laura Ballester, Frederic Pujol, Isabel Simó, Josep M. Castro, Antoni Iftimie, Simona Camps, Jordi Joven, Jorge Biomolecules Article The development of inexpensive, fast, and reliable screening tests for COVID-19 is, as yet, an unmet need. The present study was aimed at evaluating the usefulness of serum arylesterase activity of paraoxonase-1 (PON1) measurement as a screening test in patients with different severity levels of COVID-19 infection. We included 615 COVID-19-positive patients who were classified as asymptomatic, mildly symptomatic, severely symptomatic, or fatally symptomatic. Results were compared with 50 healthy volunteers, 330 patients with cancer, and 343 with morbid obesity. Results showed PON1 activity greatly decreased in COVID-19 compared to healthy volunteers; a receiver operating characteristics plot showed a high diagnostic accuracy. The degree of COVID-19 severity did not influence PON1 levels. Our results indicated that PON1 determination was efficient for disease diagnosis, but not for prognosis. Furthermore, patients with obesity or cancer presented alterations similar to those of COVID-19 patients. As such, elevated levels of PON1 indicate the absence of COVID-19, but low levels may be present in various other chronic diseases. The assay is fast and inexpensive. We suggest that PON1 measurement could be used as an initial, high cut-off point screening method, while lower values should be confirmed with the more expensive nucleic acid amplification test. MDPI 2022-06-23 /pmc/articles/PMC9312761/ /pubmed/35883435 http://dx.doi.org/10.3390/biom12070879 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gabaldó, Xavier
Juanpere, Màrius
Castañé, Helena
Rodríguez-Tomàs, Elisabet
López-Azcona, Ana Felisa
Baiges-Gaya, Gerard
Castro, Lourdes
Valverde-Díaz, Enrique
Muñoz-Blázquez, Aida
Giménez-Cuenca, Laura
Felipo-Balada, Laura
Ballester, Frederic
Pujol, Isabel
Simó, Josep M.
Castro, Antoni
Iftimie, Simona
Camps, Jordi
Joven, Jorge
Usefulness of the Measurement of Serum Paraoxonase-1 Arylesterase Activity in the Diagnoses of COVID-19
title Usefulness of the Measurement of Serum Paraoxonase-1 Arylesterase Activity in the Diagnoses of COVID-19
title_full Usefulness of the Measurement of Serum Paraoxonase-1 Arylesterase Activity in the Diagnoses of COVID-19
title_fullStr Usefulness of the Measurement of Serum Paraoxonase-1 Arylesterase Activity in the Diagnoses of COVID-19
title_full_unstemmed Usefulness of the Measurement of Serum Paraoxonase-1 Arylesterase Activity in the Diagnoses of COVID-19
title_short Usefulness of the Measurement of Serum Paraoxonase-1 Arylesterase Activity in the Diagnoses of COVID-19
title_sort usefulness of the measurement of serum paraoxonase-1 arylesterase activity in the diagnoses of covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312761/
https://www.ncbi.nlm.nih.gov/pubmed/35883435
http://dx.doi.org/10.3390/biom12070879
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