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Stem Cell-Based Therapy: A Promising Treatment for Diabetic Foot Ulcer

Diabetic foot ulcer (DFU) is a severe complication of diabetes and a challenging medical condition. Conventional treatments for DFU have not been effective enough to reduce the amputation rates, which urges the need for additional treatment. Stem cell-based therapy for DFU has been investigated over...

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Autores principales: El Hage, Racha, Knippschild, Uwe, Arnold, Tobias, Hinterseher, Irene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312797/
https://www.ncbi.nlm.nih.gov/pubmed/35884812
http://dx.doi.org/10.3390/biomedicines10071507
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author El Hage, Racha
Knippschild, Uwe
Arnold, Tobias
Hinterseher, Irene
author_facet El Hage, Racha
Knippschild, Uwe
Arnold, Tobias
Hinterseher, Irene
author_sort El Hage, Racha
collection PubMed
description Diabetic foot ulcer (DFU) is a severe complication of diabetes and a challenging medical condition. Conventional treatments for DFU have not been effective enough to reduce the amputation rates, which urges the need for additional treatment. Stem cell-based therapy for DFU has been investigated over the past years. Its therapeutic effect is through promoting angiogenesis, secreting paracrine factors, stimulating vascular differentiation, suppressing inflammation, improving collagen deposition, and immunomodulation. It is controversial which type and origin of stem cells, and which administration route would be the most optimal for therapy. We reviewed the different types and origins of stem cells and routes of administration used for the treatment of DFU in clinical and preclinical studies. Diabetes leads to the impairment of the stem cells in the diseased patients, which makes it less ideal to use autologous stem cells, and requires looking for a matching donor. Moreover, angioplasty could be complementary to stem cell therapy, and scaffolds have a positive impact on the healing process of DFU by stem cell-based therapy. In short, stem cell-based therapy is promising in the field of regenerative medicine, but more studies are still needed to determine the ideal type of stem cells required in therapy, their safety, proper dosing, and optimal administration route.
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spelling pubmed-93127972022-07-26 Stem Cell-Based Therapy: A Promising Treatment for Diabetic Foot Ulcer El Hage, Racha Knippschild, Uwe Arnold, Tobias Hinterseher, Irene Biomedicines Review Diabetic foot ulcer (DFU) is a severe complication of diabetes and a challenging medical condition. Conventional treatments for DFU have not been effective enough to reduce the amputation rates, which urges the need for additional treatment. Stem cell-based therapy for DFU has been investigated over the past years. Its therapeutic effect is through promoting angiogenesis, secreting paracrine factors, stimulating vascular differentiation, suppressing inflammation, improving collagen deposition, and immunomodulation. It is controversial which type and origin of stem cells, and which administration route would be the most optimal for therapy. We reviewed the different types and origins of stem cells and routes of administration used for the treatment of DFU in clinical and preclinical studies. Diabetes leads to the impairment of the stem cells in the diseased patients, which makes it less ideal to use autologous stem cells, and requires looking for a matching donor. Moreover, angioplasty could be complementary to stem cell therapy, and scaffolds have a positive impact on the healing process of DFU by stem cell-based therapy. In short, stem cell-based therapy is promising in the field of regenerative medicine, but more studies are still needed to determine the ideal type of stem cells required in therapy, their safety, proper dosing, and optimal administration route. MDPI 2022-06-25 /pmc/articles/PMC9312797/ /pubmed/35884812 http://dx.doi.org/10.3390/biomedicines10071507 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
El Hage, Racha
Knippschild, Uwe
Arnold, Tobias
Hinterseher, Irene
Stem Cell-Based Therapy: A Promising Treatment for Diabetic Foot Ulcer
title Stem Cell-Based Therapy: A Promising Treatment for Diabetic Foot Ulcer
title_full Stem Cell-Based Therapy: A Promising Treatment for Diabetic Foot Ulcer
title_fullStr Stem Cell-Based Therapy: A Promising Treatment for Diabetic Foot Ulcer
title_full_unstemmed Stem Cell-Based Therapy: A Promising Treatment for Diabetic Foot Ulcer
title_short Stem Cell-Based Therapy: A Promising Treatment for Diabetic Foot Ulcer
title_sort stem cell-based therapy: a promising treatment for diabetic foot ulcer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312797/
https://www.ncbi.nlm.nih.gov/pubmed/35884812
http://dx.doi.org/10.3390/biomedicines10071507
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