A Factor XIa Inhibitor Engineered from Banded Krait Venom Toxin: Efficacy and Safety in Rodent Models of Arterial and Venous Thrombosis

Activated factor XI (FXIa) is an important antithrombotic drug target. Clinical and pre-clinical data have demonstrated that its inhibition attenuates thrombosis with minimal risk of excessive bleeding. We isolated Fasxiator from the venom of banded krait Bungarus fasciatus and subsequently engineer...

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Detalles Bibliográficos
Autores principales: Chng, Wei Seng, Li, Aaron Wei Liang, Lim, Jasmine Jia Min, Leong, Esther Jia En, Amran, Fathiah S., Kini, R. Manjunatha, Chan, Mark Yan Yee, Koh, Cho Yeow
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312835/
https://www.ncbi.nlm.nih.gov/pubmed/35884984
http://dx.doi.org/10.3390/biomedicines10071679

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312835/
https://www.ncbi.nlm.nih.gov/pubmed/35884984
http://dx.doi.org/10.3390/biomedicines10071679

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