Therapeutic Potential of a Novel Vitamin D(3) Oxime Analogue, VD1-6, with CYP24A1 Enzyme Inhibitory Activity and Negligible Vitamin D Receptor Binding

The regulation of vitamin D(3) actions in humans occurs mainly through the Cytochrome P450 24-hydroxylase (CYP24A1) enzyme activity. CYP24A1 hydroxylates both 25-hydroxycholecalciferol (25(OH)D(3)) and 1,25-dihydroxycholecalciferol (1,25(OH)(2)D(3)), which is the first step of vitamin D catabolism....

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Detalles Bibliográficos
Autores principales: Alshabrawy, Ali K., Cui, Yingjie, Sylvester, Cyan, Yang, Dongqing, Petito, Emilio S., Barratt, Kate R., Sawyer, Rebecca K., Heatlie, Jessica K., Polara, Ruhi, Sykes, Matthew J., Atkins, Gerald J., Hickey, Shane M., Wiese, Michael D., Stringer, Andrea M., Liu, Zhaopeng, Anderson, Paul H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312876/
https://www.ncbi.nlm.nih.gov/pubmed/35883516
http://dx.doi.org/10.3390/biom12070960

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