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The Role of Inflammatory Cytokines in the Pathogenesis of Colorectal Carcinoma—Recent Findings and Review

The inflammatory process plays a significant role in the development of colon cancer (CRC). Intestinal cytokine networks are critical mediators of tissue homeostasis and inflammation but also impact carcinogenesis at all stages of the disease. Recent studies suggest that inflammation is of greater i...

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Autores principales: Borowczak, Jędrzej, Szczerbowski, Krzysztof, Maniewski, Mateusz, Kowalewski, Adam, Janiczek-Polewska, Marlena, Szylberg, Anna, Marszałek, Andrzej, Szylberg, Łukasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312930/
https://www.ncbi.nlm.nih.gov/pubmed/35884974
http://dx.doi.org/10.3390/biomedicines10071670
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author Borowczak, Jędrzej
Szczerbowski, Krzysztof
Maniewski, Mateusz
Kowalewski, Adam
Janiczek-Polewska, Marlena
Szylberg, Anna
Marszałek, Andrzej
Szylberg, Łukasz
author_facet Borowczak, Jędrzej
Szczerbowski, Krzysztof
Maniewski, Mateusz
Kowalewski, Adam
Janiczek-Polewska, Marlena
Szylberg, Anna
Marszałek, Andrzej
Szylberg, Łukasz
author_sort Borowczak, Jędrzej
collection PubMed
description The inflammatory process plays a significant role in the development of colon cancer (CRC). Intestinal cytokine networks are critical mediators of tissue homeostasis and inflammation but also impact carcinogenesis at all stages of the disease. Recent studies suggest that inflammation is of greater importance in the serrated pathway than in the adenoma-carcinoma pathway. Interleukins have gained the most attention due to their potential role in CRC pathogenesis and promising results of clinical trials. Malignant transformation is associated with the pro-tumorigenic and anti-tumorigenic cytokines. The harmony between proinflammatory and anti-inflammatory factors is crucial to maintaining homeostasis. Immune cells in the tumor microenvironment modulate immune sensitivity and facilitate cancer escape from immune surveillance. Therefore, clarifying the role of underlying cytokine pathways and the effects of their modulation may be an important step to improve the effectiveness of cancer immunotherapy.
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spelling pubmed-93129302022-07-26 The Role of Inflammatory Cytokines in the Pathogenesis of Colorectal Carcinoma—Recent Findings and Review Borowczak, Jędrzej Szczerbowski, Krzysztof Maniewski, Mateusz Kowalewski, Adam Janiczek-Polewska, Marlena Szylberg, Anna Marszałek, Andrzej Szylberg, Łukasz Biomedicines Review The inflammatory process plays a significant role in the development of colon cancer (CRC). Intestinal cytokine networks are critical mediators of tissue homeostasis and inflammation but also impact carcinogenesis at all stages of the disease. Recent studies suggest that inflammation is of greater importance in the serrated pathway than in the adenoma-carcinoma pathway. Interleukins have gained the most attention due to their potential role in CRC pathogenesis and promising results of clinical trials. Malignant transformation is associated with the pro-tumorigenic and anti-tumorigenic cytokines. The harmony between proinflammatory and anti-inflammatory factors is crucial to maintaining homeostasis. Immune cells in the tumor microenvironment modulate immune sensitivity and facilitate cancer escape from immune surveillance. Therefore, clarifying the role of underlying cytokine pathways and the effects of their modulation may be an important step to improve the effectiveness of cancer immunotherapy. MDPI 2022-07-11 /pmc/articles/PMC9312930/ /pubmed/35884974 http://dx.doi.org/10.3390/biomedicines10071670 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Borowczak, Jędrzej
Szczerbowski, Krzysztof
Maniewski, Mateusz
Kowalewski, Adam
Janiczek-Polewska, Marlena
Szylberg, Anna
Marszałek, Andrzej
Szylberg, Łukasz
The Role of Inflammatory Cytokines in the Pathogenesis of Colorectal Carcinoma—Recent Findings and Review
title The Role of Inflammatory Cytokines in the Pathogenesis of Colorectal Carcinoma—Recent Findings and Review
title_full The Role of Inflammatory Cytokines in the Pathogenesis of Colorectal Carcinoma—Recent Findings and Review
title_fullStr The Role of Inflammatory Cytokines in the Pathogenesis of Colorectal Carcinoma—Recent Findings and Review
title_full_unstemmed The Role of Inflammatory Cytokines in the Pathogenesis of Colorectal Carcinoma—Recent Findings and Review
title_short The Role of Inflammatory Cytokines in the Pathogenesis of Colorectal Carcinoma—Recent Findings and Review
title_sort role of inflammatory cytokines in the pathogenesis of colorectal carcinoma—recent findings and review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312930/
https://www.ncbi.nlm.nih.gov/pubmed/35884974
http://dx.doi.org/10.3390/biomedicines10071670
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