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The Role of Inflammatory Cytokines in the Pathogenesis of Colorectal Carcinoma—Recent Findings and Review
The inflammatory process plays a significant role in the development of colon cancer (CRC). Intestinal cytokine networks are critical mediators of tissue homeostasis and inflammation but also impact carcinogenesis at all stages of the disease. Recent studies suggest that inflammation is of greater i...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312930/ https://www.ncbi.nlm.nih.gov/pubmed/35884974 http://dx.doi.org/10.3390/biomedicines10071670 |
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author | Borowczak, Jędrzej Szczerbowski, Krzysztof Maniewski, Mateusz Kowalewski, Adam Janiczek-Polewska, Marlena Szylberg, Anna Marszałek, Andrzej Szylberg, Łukasz |
author_facet | Borowczak, Jędrzej Szczerbowski, Krzysztof Maniewski, Mateusz Kowalewski, Adam Janiczek-Polewska, Marlena Szylberg, Anna Marszałek, Andrzej Szylberg, Łukasz |
author_sort | Borowczak, Jędrzej |
collection | PubMed |
description | The inflammatory process plays a significant role in the development of colon cancer (CRC). Intestinal cytokine networks are critical mediators of tissue homeostasis and inflammation but also impact carcinogenesis at all stages of the disease. Recent studies suggest that inflammation is of greater importance in the serrated pathway than in the adenoma-carcinoma pathway. Interleukins have gained the most attention due to their potential role in CRC pathogenesis and promising results of clinical trials. Malignant transformation is associated with the pro-tumorigenic and anti-tumorigenic cytokines. The harmony between proinflammatory and anti-inflammatory factors is crucial to maintaining homeostasis. Immune cells in the tumor microenvironment modulate immune sensitivity and facilitate cancer escape from immune surveillance. Therefore, clarifying the role of underlying cytokine pathways and the effects of their modulation may be an important step to improve the effectiveness of cancer immunotherapy. |
format | Online Article Text |
id | pubmed-9312930 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93129302022-07-26 The Role of Inflammatory Cytokines in the Pathogenesis of Colorectal Carcinoma—Recent Findings and Review Borowczak, Jędrzej Szczerbowski, Krzysztof Maniewski, Mateusz Kowalewski, Adam Janiczek-Polewska, Marlena Szylberg, Anna Marszałek, Andrzej Szylberg, Łukasz Biomedicines Review The inflammatory process plays a significant role in the development of colon cancer (CRC). Intestinal cytokine networks are critical mediators of tissue homeostasis and inflammation but also impact carcinogenesis at all stages of the disease. Recent studies suggest that inflammation is of greater importance in the serrated pathway than in the adenoma-carcinoma pathway. Interleukins have gained the most attention due to their potential role in CRC pathogenesis and promising results of clinical trials. Malignant transformation is associated with the pro-tumorigenic and anti-tumorigenic cytokines. The harmony between proinflammatory and anti-inflammatory factors is crucial to maintaining homeostasis. Immune cells in the tumor microenvironment modulate immune sensitivity and facilitate cancer escape from immune surveillance. Therefore, clarifying the role of underlying cytokine pathways and the effects of their modulation may be an important step to improve the effectiveness of cancer immunotherapy. MDPI 2022-07-11 /pmc/articles/PMC9312930/ /pubmed/35884974 http://dx.doi.org/10.3390/biomedicines10071670 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Borowczak, Jędrzej Szczerbowski, Krzysztof Maniewski, Mateusz Kowalewski, Adam Janiczek-Polewska, Marlena Szylberg, Anna Marszałek, Andrzej Szylberg, Łukasz The Role of Inflammatory Cytokines in the Pathogenesis of Colorectal Carcinoma—Recent Findings and Review |
title | The Role of Inflammatory Cytokines in the Pathogenesis of Colorectal Carcinoma—Recent Findings and Review |
title_full | The Role of Inflammatory Cytokines in the Pathogenesis of Colorectal Carcinoma—Recent Findings and Review |
title_fullStr | The Role of Inflammatory Cytokines in the Pathogenesis of Colorectal Carcinoma—Recent Findings and Review |
title_full_unstemmed | The Role of Inflammatory Cytokines in the Pathogenesis of Colorectal Carcinoma—Recent Findings and Review |
title_short | The Role of Inflammatory Cytokines in the Pathogenesis of Colorectal Carcinoma—Recent Findings and Review |
title_sort | role of inflammatory cytokines in the pathogenesis of colorectal carcinoma—recent findings and review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312930/ https://www.ncbi.nlm.nih.gov/pubmed/35884974 http://dx.doi.org/10.3390/biomedicines10071670 |
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