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scEpiLock: A Weakly Supervised Learning Framework for cis-Regulatory Element Localization and Variant Impact Quantification for Single-Cell Epigenetic Data

Recent advances in single-cell transposase-accessible chromatin using a sequencing assay (scATAC-seq) allow cellular heterogeneity dissection and regulatory landscape reconstruction with an unprecedented resolution. However, compared to bulk-sequencing, its ultra-high missingness remarkably reduces...

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Detalles Bibliográficos
Autores principales:	Gong, Yanwen, Srinivasan, Shushrruth Sai, Zhang, Ruiyi, Kessenbrock, Kai, Zhang, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312957/ https://www.ncbi.nlm.nih.gov/pubmed/35883430 http://dx.doi.org/10.3390/biom12070874

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