Cargando…

A Novel and Selective Dopamine Transporter Inhibitor, (S)-MK-26, Promotes Hippocampal Synaptic Plasticity and Restores Effort-Related Motivational Dysfunctions

Dopamine (DA), the most abundant human brain catecholaminergic neurotransmitter, modulates key behavioral and neurological processes in young and senescent brains, including motricity, sleep, attention, emotion, learning and memory, and social and reward-seeking behaviors. The DA transporter (DAT) r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kouhnavardi, Shima, Ecevitoglu, Alev, Dragačević, Vladimir, Sanna, Fabrizio, Arias-Sandoval, Edgar, Kalaba, Predrag, Kirchhofer, Michael, Lubec, Jana, Niello, Marco, Holy, Marion, Zehl, Martin, Pillwein, Matthias, Wackerlig, Judith, Murau, Rita, Mohrmann, Andrea, Beard, Kathryn R., Sitte, Harald H., Urban, Ernst, Sagheddu, Claudia, Pistis, Marco, Plasenzotti, Roberto, Salamone, John D., Langer, Thierry, Lubec, Gert, Monje, Francisco J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312958/ https://www.ncbi.nlm.nih.gov/pubmed/35883437 http://dx.doi.org/10.3390/biom12070881

Ejemplares similares

Chirality Matters: Fine-Tuning of Novel Monoamine Reuptake Inhibitors Selectivity through Manipulation of Stereochemistry
por: Kalaba, Predrag, et al.
Publicado: (2023)

Neurophysiological and Neurochemical Effects of the Putative Cognitive Enhancer (S)-CE-123 on Mesocorticolimbic Dopamine System
por: Sagheddu, Claudia, et al.
Publicado: (2020)

The Atypical Dopamine Transporter Inhibitor CE-158 Enhances Dopamine Neurotransmission in the Prefrontal Cortex of Male Rats: A Behavioral, Electrophysiological, and Microdialysis Study
por: Sagheddu, Claudia, et al.
Publicado: (2023)

Low-Affinity/High-Selectivity Dopamine Transport Inhibition Sufficient to Rescue Cognitive Functions in the Aging Rat
por: Lubec, Jana, et al.
Publicado: (2023)

The Novel Atypical Dopamine Uptake Inhibitor (S)-CE-123 Partially Reverses the Effort-Related Effects of the Dopamine Depleting Agent Tetrabenazine and Increases Progressive Ratio Responding
por: Rotolo, Renee A., et al.
Publicado: (2019)

The Novel Analogue of Modafinil CE-158 Protects Social Memory against Interference and Triggers the Release of Dopamine in the Nucleus Accumbens of Mice
por: Ebner, Karl, et al.
Publicado: (2022)

A Novel Dopamine Transporter Inhibitor CE-123 Improves Cognitive Flexibility and Maintains Impulsivity in Healthy Male Rats
por: Nikiforuk, Agnieszka, et al.
Publicado: (2017)

Cognitive profiling and proteomic analysis of the modafinil analogue S-CE-123 in experienced aged rats
por: Gyertyán, István, et al.
Publicado: (2021)

Novel Dopamine Transporter Inhibitor, CE-123, Ameliorates Spatial Memory Deficits Induced by Maternal Separation in Adolescent Rats: Impact of Sex
por: Grochecki, Pawel, et al.
Publicado: (2022)

R-Modafinil exerts weak effects on spatial memory acquisition and dentate gyrus synaptic plasticity
por: Shanmugasundaram, Bharanidharan, et al.
Publicado: (2017)

Differential Effects of Novel Dopamine Reuptake Inhibitors on Interference With Long-Term Social Memory in Mice
por: Camats-Perna, Judith, et al.
Publicado: (2019)

Differences in Hypothalamic Lipid Profiles of Young and Aged Male Rats With Impaired and Unimpaired Spatial Cognitive Abilities and Memory
por: Wackerlig, Judith, et al.
Publicado: (2020)

Molecular species of oxidized phospholipids in brain differentiate between learning- and memory impaired and unimpaired aged rats
por: Narzt, Marie-Sophie, et al.
Publicado: (2022)

Cell-Based Radiotracer Binding and Uptake Inhibition Assays: A Comparison of In Vitro Methods to Assess the Potency of Drugs That Target Monoamine Transporters
por: Ilic, Marija, et al.
Publicado: (2020)

Corrigendum: Cell-Based Radiotracer Binding and Uptake Inhibition Assays: A Comparison of In Vitro Methods to Assess the Potency of Drugs That Target Monoamine Transporters
por: Ilic, Marija, et al.
Publicado: (2022)

Interaction Profiles of Central Nervous System Active Drugs at Human Organic Cation Transporters 1–3 and Human Plasma Membrane Monoamine Transporter
por: Angenoorth, Thomas J. F., et al.
Publicado: (2021)

miRNA-132/212 Deficiency Disrupts Selective Corticosterone Modulation of Dorsal vs. Ventral Hippocampal Metaplasticity
por: Kouhnavardi, Shima, et al.
Publicado: (2023)

Scopolamine Administration Modulates Muscarinic, Nicotinic and NMDA Receptor Systems
por: Falsafi, Soheil Keihan, et al.
Publicado: (2012)

Multilevel Impact of Prenatal Risk and Protective Factors on Stress Biology and Infant Development: Study protocol of BABIP prospective birth cohort from Turkey
por: Duman, Elif Aysimi, et al.
Publicado: (2019)

Endocannabinoid-Like Lipid Neuromodulators in the Regulation of Dopamine Signaling: Relevance for Drug Addiction
por: Sagheddu, Claudia, et al.
Publicado: (2020)

Repurposing Peroxisome Proliferator-Activated Receptor Agonists in Neurological and Psychiatric Disorders
por: Sagheddu, Claudia, et al.
Publicado: (2021)

Flotillin-1 is an evolutionary-conserved memory-related protein up-regulated in implicit and explicit learning paradigms
por: Monje, Francisco J., et al.
Publicado: (2013)

Effects of Hydroxylated Mephedrone Metabolites on Monoamine Transporter Activity in vitro
por: Niello, Marco, et al.
Publicado: (2021)

Persistent binding at dopamine transporters determines sustained psychostimulant effects
por: Niello, Marco, et al.
Publicado: (2023)

Allosteric Modulation of Neurotransmitter Transporters as a Therapeutic Strategy
por: Niello, Marco, et al.
Publicado: (2020)

A Novel Heterocyclic Compound CE-104 Enhances Spatial Working Memory in the Radial Arm Maze in Rats and Modulates the Dopaminergic System
por: Aher, Yogesh D., et al.
Publicado: (2016)

Striatal Transcriptome Reveals Differences Between Cognitively Impaired and Unimpaired Aged Male Rats
por: Korz, Volker, et al.
Publicado: (2021)

Occlusion of the human serotonin transporter is mediated by serotonin-induced conformational changes in the bundle domain
por: Gradisch, Ralph, et al.
Publicado: (2022)

Concerted Gene Expression of Hippocampal Steroid Receptors during Spatial Learning in Male Wistar Rats: A Correlation Analysis
por: Lubec, Gert, et al.
Publicado: (2016)

Combined α(2)- and D(2)-receptor blockade activates noradrenergic and dopaminergic neurons, but extracellular dopamine in the prefrontal cortex is determined by uptake and release from noradrenergic terminals
por: Sagheddu, Claudia, et al.
Publicado: (2023)

Dentate Gyrus Peroxiredoxin 6 Levels Discriminate Aged Unimpaired From Impaired Rats in a Spatial Memory Task
por: Lubec, Jana, et al.
Publicado: (2019)

The effect of modafinil on the rat dopamine transporter and dopamine receptors D1–D3 paralleling cognitive enhancement in the radial arm maze
por: Karabacak, Yasemin, et al.
Publicado: (2015)

Handling of intracellular K(+) determines voltage dependence of plasmalemmal monoamine transporter function
por: Bhat, Shreyas, et al.
Publicado: (2021)

Reduced Levels of the Synaptic Functional Regulator FMRP in Dentate Gyrus of the Aging Sprague-Dawley Rat
por: Smidak, Roman, et al.
Publicado: (2017)

Noradrenergic Source of Dopamine Assessed by Microdialysis in the Medial Prefrontal Cortex
por: Devoto, Paola, et al.
Publicado: (2020)

Age-Dependent and Pathway-Specific Bimodal Action of Nicotine on Synaptic Plasticity in the Hippocampus of Mice Lacking the miR-132/212 Genes
por: Stojanovic, Tamara, et al.
Publicado: (2022)

Are reprogrammed cells a useful tool for studying dopamine dysfunction in psychotic disorders? A review of the current evidence
por: Sauerzopf, Ulrich, et al.
Publicado: (2016)

Mass spectrometrical analysis of recombinant human growth hormone (Genotropin(®)) reveals amino acid substitutions in 2% of the expressed protein
por: Hepner, Felix, et al.
Publicado: (2005)

The Lack of Dopamine Transporter Is Associated With Conditional Associative Learning Impairments and Striatal Proteomic Changes
por: Savchenko, Artem, et al.
Publicado: (2022)

Age and cognitive status dependent differences in blood steroid and thyroid hormone concentrations in intact male rats
por: Maliković, Jovana, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_487lebcg7danqunp4nd195hbjp