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Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies
Colorectal cancer is one of the most prevalent cancer types. Although there have been breakthroughs in its treatments, a better understanding of the molecular mechanisms and genetic involvement in colorectal cancer will have a substantial role in producing novel and targeted treatments with better s...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312989/ https://www.ncbi.nlm.nih.gov/pubmed/35883434 http://dx.doi.org/10.3390/biom12070878 |
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author | Moshawih, Said Lim, Ai Fern Ardianto, Chrismawan Goh, Khang Wen Kifli, Nurolaini Goh, Hui Poh Jarrar, Qais Ming, Long Chiau |
author_facet | Moshawih, Said Lim, Ai Fern Ardianto, Chrismawan Goh, Khang Wen Kifli, Nurolaini Goh, Hui Poh Jarrar, Qais Ming, Long Chiau |
author_sort | Moshawih, Said |
collection | PubMed |
description | Colorectal cancer is one of the most prevalent cancer types. Although there have been breakthroughs in its treatments, a better understanding of the molecular mechanisms and genetic involvement in colorectal cancer will have a substantial role in producing novel and targeted treatments with better safety profiles. In this review, the main molecular pathways and driver genes that are responsible for initiating and propagating the cascade of signaling molecules reaching carcinoma and the aggressive metastatic stages of colorectal cancer were presented. Protein kinases involved in colorectal cancer, as much as other cancers, have seen much focus and committed efforts due to their crucial role in subsidizing, inhibiting, or changing the disease course. Moreover, notable improvements in colorectal cancer treatments with in silico studies and the enhanced selectivity on specific macromolecular targets were discussed. Besides, the selective multi-target agents have been made easier by employing in silico methods in molecular de novo synthesis or target identification and drug repurposing. |
format | Online Article Text |
id | pubmed-9312989 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93129892022-07-26 Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies Moshawih, Said Lim, Ai Fern Ardianto, Chrismawan Goh, Khang Wen Kifli, Nurolaini Goh, Hui Poh Jarrar, Qais Ming, Long Chiau Biomolecules Review Colorectal cancer is one of the most prevalent cancer types. Although there have been breakthroughs in its treatments, a better understanding of the molecular mechanisms and genetic involvement in colorectal cancer will have a substantial role in producing novel and targeted treatments with better safety profiles. In this review, the main molecular pathways and driver genes that are responsible for initiating and propagating the cascade of signaling molecules reaching carcinoma and the aggressive metastatic stages of colorectal cancer were presented. Protein kinases involved in colorectal cancer, as much as other cancers, have seen much focus and committed efforts due to their crucial role in subsidizing, inhibiting, or changing the disease course. Moreover, notable improvements in colorectal cancer treatments with in silico studies and the enhanced selectivity on specific macromolecular targets were discussed. Besides, the selective multi-target agents have been made easier by employing in silico methods in molecular de novo synthesis or target identification and drug repurposing. MDPI 2022-06-23 /pmc/articles/PMC9312989/ /pubmed/35883434 http://dx.doi.org/10.3390/biom12070878 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Moshawih, Said Lim, Ai Fern Ardianto, Chrismawan Goh, Khang Wen Kifli, Nurolaini Goh, Hui Poh Jarrar, Qais Ming, Long Chiau Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies |
title | Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies |
title_full | Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies |
title_fullStr | Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies |
title_full_unstemmed | Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies |
title_short | Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies |
title_sort | target-based small molecule drug discovery for colorectal cancer: a review of molecular pathways and in silico studies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312989/ https://www.ncbi.nlm.nih.gov/pubmed/35883434 http://dx.doi.org/10.3390/biom12070878 |
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