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Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies

Colorectal cancer is one of the most prevalent cancer types. Although there have been breakthroughs in its treatments, a better understanding of the molecular mechanisms and genetic involvement in colorectal cancer will have a substantial role in producing novel and targeted treatments with better s...

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Autores principales: Moshawih, Said, Lim, Ai Fern, Ardianto, Chrismawan, Goh, Khang Wen, Kifli, Nurolaini, Goh, Hui Poh, Jarrar, Qais, Ming, Long Chiau
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312989/
https://www.ncbi.nlm.nih.gov/pubmed/35883434
http://dx.doi.org/10.3390/biom12070878
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author Moshawih, Said
Lim, Ai Fern
Ardianto, Chrismawan
Goh, Khang Wen
Kifli, Nurolaini
Goh, Hui Poh
Jarrar, Qais
Ming, Long Chiau
author_facet Moshawih, Said
Lim, Ai Fern
Ardianto, Chrismawan
Goh, Khang Wen
Kifli, Nurolaini
Goh, Hui Poh
Jarrar, Qais
Ming, Long Chiau
author_sort Moshawih, Said
collection PubMed
description Colorectal cancer is one of the most prevalent cancer types. Although there have been breakthroughs in its treatments, a better understanding of the molecular mechanisms and genetic involvement in colorectal cancer will have a substantial role in producing novel and targeted treatments with better safety profiles. In this review, the main molecular pathways and driver genes that are responsible for initiating and propagating the cascade of signaling molecules reaching carcinoma and the aggressive metastatic stages of colorectal cancer were presented. Protein kinases involved in colorectal cancer, as much as other cancers, have seen much focus and committed efforts due to their crucial role in subsidizing, inhibiting, or changing the disease course. Moreover, notable improvements in colorectal cancer treatments with in silico studies and the enhanced selectivity on specific macromolecular targets were discussed. Besides, the selective multi-target agents have been made easier by employing in silico methods in molecular de novo synthesis or target identification and drug repurposing.
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spelling pubmed-93129892022-07-26 Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies Moshawih, Said Lim, Ai Fern Ardianto, Chrismawan Goh, Khang Wen Kifli, Nurolaini Goh, Hui Poh Jarrar, Qais Ming, Long Chiau Biomolecules Review Colorectal cancer is one of the most prevalent cancer types. Although there have been breakthroughs in its treatments, a better understanding of the molecular mechanisms and genetic involvement in colorectal cancer will have a substantial role in producing novel and targeted treatments with better safety profiles. In this review, the main molecular pathways and driver genes that are responsible for initiating and propagating the cascade of signaling molecules reaching carcinoma and the aggressive metastatic stages of colorectal cancer were presented. Protein kinases involved in colorectal cancer, as much as other cancers, have seen much focus and committed efforts due to their crucial role in subsidizing, inhibiting, or changing the disease course. Moreover, notable improvements in colorectal cancer treatments with in silico studies and the enhanced selectivity on specific macromolecular targets were discussed. Besides, the selective multi-target agents have been made easier by employing in silico methods in molecular de novo synthesis or target identification and drug repurposing. MDPI 2022-06-23 /pmc/articles/PMC9312989/ /pubmed/35883434 http://dx.doi.org/10.3390/biom12070878 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Moshawih, Said
Lim, Ai Fern
Ardianto, Chrismawan
Goh, Khang Wen
Kifli, Nurolaini
Goh, Hui Poh
Jarrar, Qais
Ming, Long Chiau
Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies
title Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies
title_full Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies
title_fullStr Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies
title_full_unstemmed Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies
title_short Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies
title_sort target-based small molecule drug discovery for colorectal cancer: a review of molecular pathways and in silico studies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312989/
https://www.ncbi.nlm.nih.gov/pubmed/35883434
http://dx.doi.org/10.3390/biom12070878
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