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Maternal Body Mass Index Is Associated with Profile Variation in Circulating MicroRNAs at First Trimester of Pregnancy

Many women enter pregnancy with overweight and obesity, which are associated with complications for both the expectant mother and her child. MicroRNAs (miRNAs) are short non-coding RNAs that regulate many biological processes, including energy metabolism. Our study aimed to identify first trimester...

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Autores principales: Thibeault, Kathrine, Légaré, Cécilia, Desgagné, Véronique, White, Frédérique, Clément, Andrée-Anne, Scott, Michelle S., Jacques, Pierre-Étienne, Guérin, Renée, Perron, Patrice, Hivert, Marie-France, Bouchard, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313007/
https://www.ncbi.nlm.nih.gov/pubmed/35885031
http://dx.doi.org/10.3390/biomedicines10071726
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author Thibeault, Kathrine
Légaré, Cécilia
Desgagné, Véronique
White, Frédérique
Clément, Andrée-Anne
Scott, Michelle S.
Jacques, Pierre-Étienne
Guérin, Renée
Perron, Patrice
Hivert, Marie-France
Bouchard, Luigi
author_facet Thibeault, Kathrine
Légaré, Cécilia
Desgagné, Véronique
White, Frédérique
Clément, Andrée-Anne
Scott, Michelle S.
Jacques, Pierre-Étienne
Guérin, Renée
Perron, Patrice
Hivert, Marie-France
Bouchard, Luigi
author_sort Thibeault, Kathrine
collection PubMed
description Many women enter pregnancy with overweight and obesity, which are associated with complications for both the expectant mother and her child. MicroRNAs (miRNAs) are short non-coding RNAs that regulate many biological processes, including energy metabolism. Our study aimed to identify first trimester plasmatic miRNAs associated with maternal body mass index (BMI) in early pregnancy. We sequenced a total of 658 plasma samples collected between the 4th and 16th week of pregnancy from two independent prospective birth cohorts (Gen3G and 3D). In each cohort, we assessed associations between early pregnancy maternal BMI and plasmatic miRNAs using DESeq2 R package, adjusting for sequencing run and lane, gestational age, maternal age at the first trimester of pregnancy and parity. A total of 38 miRNAs were associated (FDR q < 0.05) with BMI in the Gen3G cohort and were replicated (direction and magnitude of the fold change) in the 3D cohort, including 22 with a nominal p-value < 0.05. Some of these miRNAs were enriched in fatty acid metabolism-related pathways. We identified first trimester plasmatic miRNAs associated with maternal BMI. These miRNAs potentially regulate fatty acid metabolism-related pathways, supporting the hypothesis of their potential contribution to energy metabolism regulation in early pregnancy.
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spelling pubmed-93130072022-07-26 Maternal Body Mass Index Is Associated with Profile Variation in Circulating MicroRNAs at First Trimester of Pregnancy Thibeault, Kathrine Légaré, Cécilia Desgagné, Véronique White, Frédérique Clément, Andrée-Anne Scott, Michelle S. Jacques, Pierre-Étienne Guérin, Renée Perron, Patrice Hivert, Marie-France Bouchard, Luigi Biomedicines Article Many women enter pregnancy with overweight and obesity, which are associated with complications for both the expectant mother and her child. MicroRNAs (miRNAs) are short non-coding RNAs that regulate many biological processes, including energy metabolism. Our study aimed to identify first trimester plasmatic miRNAs associated with maternal body mass index (BMI) in early pregnancy. We sequenced a total of 658 plasma samples collected between the 4th and 16th week of pregnancy from two independent prospective birth cohorts (Gen3G and 3D). In each cohort, we assessed associations between early pregnancy maternal BMI and plasmatic miRNAs using DESeq2 R package, adjusting for sequencing run and lane, gestational age, maternal age at the first trimester of pregnancy and parity. A total of 38 miRNAs were associated (FDR q < 0.05) with BMI in the Gen3G cohort and were replicated (direction and magnitude of the fold change) in the 3D cohort, including 22 with a nominal p-value < 0.05. Some of these miRNAs were enriched in fatty acid metabolism-related pathways. We identified first trimester plasmatic miRNAs associated with maternal BMI. These miRNAs potentially regulate fatty acid metabolism-related pathways, supporting the hypothesis of their potential contribution to energy metabolism regulation in early pregnancy. MDPI 2022-07-18 /pmc/articles/PMC9313007/ /pubmed/35885031 http://dx.doi.org/10.3390/biomedicines10071726 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Thibeault, Kathrine
Légaré, Cécilia
Desgagné, Véronique
White, Frédérique
Clément, Andrée-Anne
Scott, Michelle S.
Jacques, Pierre-Étienne
Guérin, Renée
Perron, Patrice
Hivert, Marie-France
Bouchard, Luigi
Maternal Body Mass Index Is Associated with Profile Variation in Circulating MicroRNAs at First Trimester of Pregnancy
title Maternal Body Mass Index Is Associated with Profile Variation in Circulating MicroRNAs at First Trimester of Pregnancy
title_full Maternal Body Mass Index Is Associated with Profile Variation in Circulating MicroRNAs at First Trimester of Pregnancy
title_fullStr Maternal Body Mass Index Is Associated with Profile Variation in Circulating MicroRNAs at First Trimester of Pregnancy
title_full_unstemmed Maternal Body Mass Index Is Associated with Profile Variation in Circulating MicroRNAs at First Trimester of Pregnancy
title_short Maternal Body Mass Index Is Associated with Profile Variation in Circulating MicroRNAs at First Trimester of Pregnancy
title_sort maternal body mass index is associated with profile variation in circulating micrornas at first trimester of pregnancy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313007/
https://www.ncbi.nlm.nih.gov/pubmed/35885031
http://dx.doi.org/10.3390/biomedicines10071726
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