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Micro- and Nanosized Carriers for Nose-to-Brain Drug Delivery in Neurodegenerative Disorders
Neurodegenerative disorders (NDs) have become a serious health problem worldwide due to the rapid increase in the number of people that are affected and the constantly aging population. Among all NDs, Alzheimer’s and Parkinson’s disease are the most common, and many efforts have been made in the dev...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313014/ https://www.ncbi.nlm.nih.gov/pubmed/35885011 http://dx.doi.org/10.3390/biomedicines10071706 |
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author | Boyuklieva, Radka Pilicheva, Bissera |
author_facet | Boyuklieva, Radka Pilicheva, Bissera |
author_sort | Boyuklieva, Radka |
collection | PubMed |
description | Neurodegenerative disorders (NDs) have become a serious health problem worldwide due to the rapid increase in the number of people that are affected and the constantly aging population. Among all NDs, Alzheimer’s and Parkinson’s disease are the most common, and many efforts have been made in the development of effective and reliable therapeutic strategies. The intranasal route of drug administration offers numerous advantages, such as bypassing the blood–brain barrier and providing a direct entrance to the brain through the olfactory and trigeminal neurons. The present review summarizes the available information on recent advances in micro- and nanoscale nose-to-brain drug-delivery systems as a novel strategy for the treatment of Alzheimer’s and Parkinson’s disease. Specifically, polymer- and lipid-base micro- and nanoparticles have been studied as a feasible approach to increase the brain bioavailability of certain drugs. Furthermore, nanocomposites are discussed as a suitable formulation for administration into the nasal cavity. |
format | Online Article Text |
id | pubmed-9313014 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93130142022-07-26 Micro- and Nanosized Carriers for Nose-to-Brain Drug Delivery in Neurodegenerative Disorders Boyuklieva, Radka Pilicheva, Bissera Biomedicines Review Neurodegenerative disorders (NDs) have become a serious health problem worldwide due to the rapid increase in the number of people that are affected and the constantly aging population. Among all NDs, Alzheimer’s and Parkinson’s disease are the most common, and many efforts have been made in the development of effective and reliable therapeutic strategies. The intranasal route of drug administration offers numerous advantages, such as bypassing the blood–brain barrier and providing a direct entrance to the brain through the olfactory and trigeminal neurons. The present review summarizes the available information on recent advances in micro- and nanoscale nose-to-brain drug-delivery systems as a novel strategy for the treatment of Alzheimer’s and Parkinson’s disease. Specifically, polymer- and lipid-base micro- and nanoparticles have been studied as a feasible approach to increase the brain bioavailability of certain drugs. Furthermore, nanocomposites are discussed as a suitable formulation for administration into the nasal cavity. MDPI 2022-07-14 /pmc/articles/PMC9313014/ /pubmed/35885011 http://dx.doi.org/10.3390/biomedicines10071706 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Boyuklieva, Radka Pilicheva, Bissera Micro- and Nanosized Carriers for Nose-to-Brain Drug Delivery in Neurodegenerative Disorders |
title | Micro- and Nanosized Carriers for Nose-to-Brain Drug Delivery in Neurodegenerative Disorders |
title_full | Micro- and Nanosized Carriers for Nose-to-Brain Drug Delivery in Neurodegenerative Disorders |
title_fullStr | Micro- and Nanosized Carriers for Nose-to-Brain Drug Delivery in Neurodegenerative Disorders |
title_full_unstemmed | Micro- and Nanosized Carriers for Nose-to-Brain Drug Delivery in Neurodegenerative Disorders |
title_short | Micro- and Nanosized Carriers for Nose-to-Brain Drug Delivery in Neurodegenerative Disorders |
title_sort | micro- and nanosized carriers for nose-to-brain drug delivery in neurodegenerative disorders |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313014/ https://www.ncbi.nlm.nih.gov/pubmed/35885011 http://dx.doi.org/10.3390/biomedicines10071706 |
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