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Motoric Cognitive Risk Syndrome, Subtypes and 8-Year All-Cause Mortality in Aging Phenotypes: The Salus in Apulia Study

Background: This study aims to establish the key clinical features of different motoric cognitive risk (MCR) subtypes based on individual quantitative measures of cognitive impairment and to compare their predictive power on survival over an 8-year observation time. Methods: We analyzed data from a...

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Autores principales: Bortone, Ilaria, Zupo, Roberta, Castellana, Fabio, Aresta, Simona, Lampignano, Luisa, Sciarra, Sabrina, Griseta, Chiara, Stallone, Tommaso Antonio, Sborgia, Giancarlo, Lozupone, Madia, Panza, Francesco, Lagravinese, Gianvito, Battista, Petronilla, Sardone, Rodolfo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313038/
https://www.ncbi.nlm.nih.gov/pubmed/35884669
http://dx.doi.org/10.3390/brainsci12070861
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author Bortone, Ilaria
Zupo, Roberta
Castellana, Fabio
Aresta, Simona
Lampignano, Luisa
Sciarra, Sabrina
Griseta, Chiara
Stallone, Tommaso Antonio
Sborgia, Giancarlo
Lozupone, Madia
Panza, Francesco
Lagravinese, Gianvito
Battista, Petronilla
Sardone, Rodolfo
author_facet Bortone, Ilaria
Zupo, Roberta
Castellana, Fabio
Aresta, Simona
Lampignano, Luisa
Sciarra, Sabrina
Griseta, Chiara
Stallone, Tommaso Antonio
Sborgia, Giancarlo
Lozupone, Madia
Panza, Francesco
Lagravinese, Gianvito
Battista, Petronilla
Sardone, Rodolfo
author_sort Bortone, Ilaria
collection PubMed
description Background: This study aims to establish the key clinical features of different motoric cognitive risk (MCR) subtypes based on individual quantitative measures of cognitive impairment and to compare their predictive power on survival over an 8-year observation time. Methods: We analyzed data from a population-based study of 1138 subjects aged 65 years and older in south Italy. These individuals were targeted and allocated to subtypes of the MCR phenotype according to the slowness criterion plus one other different cognitive domain for each characterized phenotype (Subjective Cognitive Complaint [SCC]; Global Function [Mini Mental State Examination (MMSE) < 24]; or a combination of both). Clinical evaluation and laboratory assays, along with a comprehensive battery of neuropsychological and physical tests, completed the sample investigation. Results: MCR prevalence was found to be 9.8% (n = 112), 3.6% (n = 41), 3.4% (n = 39) and 1.8% (n = 21) for the MCR, MCR-GlobalFunction, MCR-StructuredSCC and MCR-SCC and GlobalFunction, respectively. Univariate Cox survival analysis showed an association only of the MCR-GlobalFunction subtype with an almost three-fold increased risk of overall death as compared to the other counterparts (HR 2.53, 95%CI 1.28 to 4.99) over an 8-year observation period. Using Generalized Estimating Equations (GEE) for clustered survival data, we found that MCR males had an increased and significant mortality risk with respect to MCR female subjects. Conclusions: MCR phenotypes assigned to the MMSE cognitive domain are more likely to have an increased risk of overall mortality, and gender showed a huge effect on the risk of death for MCR subjects over the 8-year observation.
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spelling pubmed-93130382022-07-26 Motoric Cognitive Risk Syndrome, Subtypes and 8-Year All-Cause Mortality in Aging Phenotypes: The Salus in Apulia Study Bortone, Ilaria Zupo, Roberta Castellana, Fabio Aresta, Simona Lampignano, Luisa Sciarra, Sabrina Griseta, Chiara Stallone, Tommaso Antonio Sborgia, Giancarlo Lozupone, Madia Panza, Francesco Lagravinese, Gianvito Battista, Petronilla Sardone, Rodolfo Brain Sci Article Background: This study aims to establish the key clinical features of different motoric cognitive risk (MCR) subtypes based on individual quantitative measures of cognitive impairment and to compare their predictive power on survival over an 8-year observation time. Methods: We analyzed data from a population-based study of 1138 subjects aged 65 years and older in south Italy. These individuals were targeted and allocated to subtypes of the MCR phenotype according to the slowness criterion plus one other different cognitive domain for each characterized phenotype (Subjective Cognitive Complaint [SCC]; Global Function [Mini Mental State Examination (MMSE) < 24]; or a combination of both). Clinical evaluation and laboratory assays, along with a comprehensive battery of neuropsychological and physical tests, completed the sample investigation. Results: MCR prevalence was found to be 9.8% (n = 112), 3.6% (n = 41), 3.4% (n = 39) and 1.8% (n = 21) for the MCR, MCR-GlobalFunction, MCR-StructuredSCC and MCR-SCC and GlobalFunction, respectively. Univariate Cox survival analysis showed an association only of the MCR-GlobalFunction subtype with an almost three-fold increased risk of overall death as compared to the other counterparts (HR 2.53, 95%CI 1.28 to 4.99) over an 8-year observation period. Using Generalized Estimating Equations (GEE) for clustered survival data, we found that MCR males had an increased and significant mortality risk with respect to MCR female subjects. Conclusions: MCR phenotypes assigned to the MMSE cognitive domain are more likely to have an increased risk of overall mortality, and gender showed a huge effect on the risk of death for MCR subjects over the 8-year observation. MDPI 2022-06-29 /pmc/articles/PMC9313038/ /pubmed/35884669 http://dx.doi.org/10.3390/brainsci12070861 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bortone, Ilaria
Zupo, Roberta
Castellana, Fabio
Aresta, Simona
Lampignano, Luisa
Sciarra, Sabrina
Griseta, Chiara
Stallone, Tommaso Antonio
Sborgia, Giancarlo
Lozupone, Madia
Panza, Francesco
Lagravinese, Gianvito
Battista, Petronilla
Sardone, Rodolfo
Motoric Cognitive Risk Syndrome, Subtypes and 8-Year All-Cause Mortality in Aging Phenotypes: The Salus in Apulia Study
title Motoric Cognitive Risk Syndrome, Subtypes and 8-Year All-Cause Mortality in Aging Phenotypes: The Salus in Apulia Study
title_full Motoric Cognitive Risk Syndrome, Subtypes and 8-Year All-Cause Mortality in Aging Phenotypes: The Salus in Apulia Study
title_fullStr Motoric Cognitive Risk Syndrome, Subtypes and 8-Year All-Cause Mortality in Aging Phenotypes: The Salus in Apulia Study
title_full_unstemmed Motoric Cognitive Risk Syndrome, Subtypes and 8-Year All-Cause Mortality in Aging Phenotypes: The Salus in Apulia Study
title_short Motoric Cognitive Risk Syndrome, Subtypes and 8-Year All-Cause Mortality in Aging Phenotypes: The Salus in Apulia Study
title_sort motoric cognitive risk syndrome, subtypes and 8-year all-cause mortality in aging phenotypes: the salus in apulia study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313038/
https://www.ncbi.nlm.nih.gov/pubmed/35884669
http://dx.doi.org/10.3390/brainsci12070861
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