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Physiological and Neural Changes with Rehabilitation Training in a 53-Year Amputee: A Case Study

Many people who received amputation wear sEMG prostheses to assist in their daily lives. How these prostheses promote muscle growth and change neural activity remains elusive. We recruited a subject who had his left hand amputated for over 53 years to participate in a six-week rehabilitation trainin...

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Autores principales: Mao, Lin, Lu, Xiao, Yu, Chao, Yin, Kuiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313058/
https://www.ncbi.nlm.nih.gov/pubmed/35884639
http://dx.doi.org/10.3390/brainsci12070832
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author Mao, Lin
Lu, Xiao
Yu, Chao
Yin, Kuiying
author_facet Mao, Lin
Lu, Xiao
Yu, Chao
Yin, Kuiying
author_sort Mao, Lin
collection PubMed
description Many people who received amputation wear sEMG prostheses to assist in their daily lives. How these prostheses promote muscle growth and change neural activity remains elusive. We recruited a subject who had his left hand amputated for over 53 years to participate in a six-week rehabilitation training using an sEMG prosthesis. We tracked the muscle growth of his left forearm and changes in neural activity over six weeks. The subject showed an increase in fast muscle fiber in his left forearm during the training period. In an analysis of complex networks of neural activity, we observed that the [Formula: see text]-band network decreased in efficiency but increased in its capability to integrate information. This could be due to an expansion of the network to accommodate new movements enabled by rehabilitation training. Differently, we found that in the [Formula: see text]-band network, a band frequency related to motor functions, the efficiency of the network initially decreased but started to increase after approximately three weeks. The ability to integrate network information showed an opposite trend compared with its efficiency. rMT values, a measure that negatively correlates with cortical excitability, showed a sharp decrease in the first three weeks, suggesting an increase in cortical excitability. In the last three weeks, there was little to no change. These data indicate that rehabilitation training promoted fast muscle fiber growth and introduced neural activity changes in the subject during the first three weeks of training. Our study gave insights into how rehabilitation training with an sEMG prosthesis could lead to physiological and neural changes in amputees.
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spelling pubmed-93130582022-07-26 Physiological and Neural Changes with Rehabilitation Training in a 53-Year Amputee: A Case Study Mao, Lin Lu, Xiao Yu, Chao Yin, Kuiying Brain Sci Case Report Many people who received amputation wear sEMG prostheses to assist in their daily lives. How these prostheses promote muscle growth and change neural activity remains elusive. We recruited a subject who had his left hand amputated for over 53 years to participate in a six-week rehabilitation training using an sEMG prosthesis. We tracked the muscle growth of his left forearm and changes in neural activity over six weeks. The subject showed an increase in fast muscle fiber in his left forearm during the training period. In an analysis of complex networks of neural activity, we observed that the [Formula: see text]-band network decreased in efficiency but increased in its capability to integrate information. This could be due to an expansion of the network to accommodate new movements enabled by rehabilitation training. Differently, we found that in the [Formula: see text]-band network, a band frequency related to motor functions, the efficiency of the network initially decreased but started to increase after approximately three weeks. The ability to integrate network information showed an opposite trend compared with its efficiency. rMT values, a measure that negatively correlates with cortical excitability, showed a sharp decrease in the first three weeks, suggesting an increase in cortical excitability. In the last three weeks, there was little to no change. These data indicate that rehabilitation training promoted fast muscle fiber growth and introduced neural activity changes in the subject during the first three weeks of training. Our study gave insights into how rehabilitation training with an sEMG prosthesis could lead to physiological and neural changes in amputees. MDPI 2022-06-26 /pmc/articles/PMC9313058/ /pubmed/35884639 http://dx.doi.org/10.3390/brainsci12070832 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Mao, Lin
Lu, Xiao
Yu, Chao
Yin, Kuiying
Physiological and Neural Changes with Rehabilitation Training in a 53-Year Amputee: A Case Study
title Physiological and Neural Changes with Rehabilitation Training in a 53-Year Amputee: A Case Study
title_full Physiological and Neural Changes with Rehabilitation Training in a 53-Year Amputee: A Case Study
title_fullStr Physiological and Neural Changes with Rehabilitation Training in a 53-Year Amputee: A Case Study
title_full_unstemmed Physiological and Neural Changes with Rehabilitation Training in a 53-Year Amputee: A Case Study
title_short Physiological and Neural Changes with Rehabilitation Training in a 53-Year Amputee: A Case Study
title_sort physiological and neural changes with rehabilitation training in a 53-year amputee: a case study
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313058/
https://www.ncbi.nlm.nih.gov/pubmed/35884639
http://dx.doi.org/10.3390/brainsci12070832
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