Effect of Anti-Hypertensive Medication on Plasma Concentrations of Lysyl Oxidase: Evidence for Aldosterone-IL-6-Dependent Regulation of Lysyl Oxidase Blood Concentration

Lysyl oxidase (LOX) is a secretory protein that catalyzes elastin and collagen cross-linking. Lowering LOX expression and activity in endothelial cells is associated with a high risk of aneurysms and vascular malformation. Interleukin-6 (IL-6), elevated in hypertension, is known to suppress LOX expr...

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Detalles Bibliográficos
Autores principales: Schreckenberg, Rolf, Dörr, Oliver, Pankuweit, Sabine, Schieffer, Bernhard, Troidl, Christian, Nef, Holger, Hamm, Christian W., Rohrbach, Susanne, Li, Ling, Schlüter, Klaus-Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313098/
https://www.ncbi.nlm.nih.gov/pubmed/35885053
http://dx.doi.org/10.3390/biomedicines10071748

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