Trogocytosis and fratricide killing impede MSLN-directed CAR T cell functionality

Successful translation of chimeric antigen receptor (CAR) T cell therapy for the treatment of solid tumors has proved to be troublesome, mainly due to the complex tumor microenvironment promoting T cell dysfunction and antigen heterogeneity. Mesothelin (MSLN) has emerged as an attractive target for...

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Detalles Bibliográficos
Autores principales: Schoutrop, Esther, Renken, Stefanie, Micallef Nilsson, Isabella, Hahn, Paula, Poiret, Thomas, Kiessling, Rolf, Wickström, Stina L, Mattsson, Jonas, Magalhaes, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313125/
https://www.ncbi.nlm.nih.gov/pubmed/35898704
http://dx.doi.org/10.1080/2162402X.2022.2093426

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