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Gender Differences in Non-Persistence with Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers among Older Hypertensive Patients with Peripheral Arterial Disease

The beneficial effects of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) in hypertensive patients with peripheral arterial disease (PAD) depends on long-term persistence. The aims of our study were to analyse gender differences in non-persistence with ACEIs...

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Autores principales: Wawruch, Martin, Murin, Jan, Tesar, Tomas, Paduchova, Martina, Petrova, Miriam, Celovska, Denisa, Havelkova, Beata, Trnka, Michal, Masarykova, Lucia, Alfian, Sofa D., Aarnio, Emma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313155/
https://www.ncbi.nlm.nih.gov/pubmed/35884784
http://dx.doi.org/10.3390/biomedicines10071479
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author Wawruch, Martin
Murin, Jan
Tesar, Tomas
Paduchova, Martina
Petrova, Miriam
Celovska, Denisa
Havelkova, Beata
Trnka, Michal
Masarykova, Lucia
Alfian, Sofa D.
Aarnio, Emma
author_facet Wawruch, Martin
Murin, Jan
Tesar, Tomas
Paduchova, Martina
Petrova, Miriam
Celovska, Denisa
Havelkova, Beata
Trnka, Michal
Masarykova, Lucia
Alfian, Sofa D.
Aarnio, Emma
author_sort Wawruch, Martin
collection PubMed
description The beneficial effects of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) in hypertensive patients with peripheral arterial disease (PAD) depends on long-term persistence. The aims of our study were to analyse gender differences in non-persistence with ACEIs/ARBs, and to identify the characteristics associated with the likelihood of non-persistence. Our study cohort included 7080 hypertensive patients (4005 women and 3075 men) aged ≥65 years, treated with ACEIs/ARBs, in whom PAD was diagnosed between 1 January and 31 December 2012. Non-persistence was identified according to a treatment gap of 6 months without ACEI/ARB prescriptions. The characteristics associated with non-persistence were identified using the Cox regression model. At the end of the 5-year follow-up, 23.2% of the whole study cohort, 22.3% of men, and 23.9% of women were non-persistent with ACEIs/ARBs, with no significant gender differences in persistence. While a number of characteristics were associated with non-persistence, only three characteristics had consistent, statistically significant associations in both genders: being a new ACEI/ARB user increased the likelihood of non-persistence, and general practitioner as index prescriber and increasing the overall number of medications decreased the likelihood of non-persistence. Information on the differences in characteristics that are associated with non-persistence between genders may help to better identify patients for whom special attention should be paid to improve their persistence.
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spelling pubmed-93131552022-07-26 Gender Differences in Non-Persistence with Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers among Older Hypertensive Patients with Peripheral Arterial Disease Wawruch, Martin Murin, Jan Tesar, Tomas Paduchova, Martina Petrova, Miriam Celovska, Denisa Havelkova, Beata Trnka, Michal Masarykova, Lucia Alfian, Sofa D. Aarnio, Emma Biomedicines Article The beneficial effects of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) in hypertensive patients with peripheral arterial disease (PAD) depends on long-term persistence. The aims of our study were to analyse gender differences in non-persistence with ACEIs/ARBs, and to identify the characteristics associated with the likelihood of non-persistence. Our study cohort included 7080 hypertensive patients (4005 women and 3075 men) aged ≥65 years, treated with ACEIs/ARBs, in whom PAD was diagnosed between 1 January and 31 December 2012. Non-persistence was identified according to a treatment gap of 6 months without ACEI/ARB prescriptions. The characteristics associated with non-persistence were identified using the Cox regression model. At the end of the 5-year follow-up, 23.2% of the whole study cohort, 22.3% of men, and 23.9% of women were non-persistent with ACEIs/ARBs, with no significant gender differences in persistence. While a number of characteristics were associated with non-persistence, only three characteristics had consistent, statistically significant associations in both genders: being a new ACEI/ARB user increased the likelihood of non-persistence, and general practitioner as index prescriber and increasing the overall number of medications decreased the likelihood of non-persistence. Information on the differences in characteristics that are associated with non-persistence between genders may help to better identify patients for whom special attention should be paid to improve their persistence. MDPI 2022-06-22 /pmc/articles/PMC9313155/ /pubmed/35884784 http://dx.doi.org/10.3390/biomedicines10071479 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wawruch, Martin
Murin, Jan
Tesar, Tomas
Paduchova, Martina
Petrova, Miriam
Celovska, Denisa
Havelkova, Beata
Trnka, Michal
Masarykova, Lucia
Alfian, Sofa D.
Aarnio, Emma
Gender Differences in Non-Persistence with Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers among Older Hypertensive Patients with Peripheral Arterial Disease
title Gender Differences in Non-Persistence with Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers among Older Hypertensive Patients with Peripheral Arterial Disease
title_full Gender Differences in Non-Persistence with Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers among Older Hypertensive Patients with Peripheral Arterial Disease
title_fullStr Gender Differences in Non-Persistence with Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers among Older Hypertensive Patients with Peripheral Arterial Disease
title_full_unstemmed Gender Differences in Non-Persistence with Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers among Older Hypertensive Patients with Peripheral Arterial Disease
title_short Gender Differences in Non-Persistence with Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers among Older Hypertensive Patients with Peripheral Arterial Disease
title_sort gender differences in non-persistence with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers among older hypertensive patients with peripheral arterial disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313155/
https://www.ncbi.nlm.nih.gov/pubmed/35884784
http://dx.doi.org/10.3390/biomedicines10071479
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