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A Pilot Study on Plasma and Urine Neurotransmitter Levels in Children with Tic Disorders
Background: Tic disorders (TDs), including Tourette syndrome, are childhood-onset neuropsychiatric disorders characterized by motor and/or vocal tics that commonly affect children’s physical and mental health. The pathogenesis of TDs may be related to abnormal neurotransmitters in the cortico-striat...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313232/ https://www.ncbi.nlm.nih.gov/pubmed/35884687 http://dx.doi.org/10.3390/brainsci12070880 |
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author | Qian, Qiao-Qiao Tan, Qian-Qian Sun, Dan Lu, Qing Xin, Ying-Ying Wu, Qian Zhou, Yong Liu, Yang-Xi Tian, Pei-Chao Liu, Zhi-Sheng |
author_facet | Qian, Qiao-Qiao Tan, Qian-Qian Sun, Dan Lu, Qing Xin, Ying-Ying Wu, Qian Zhou, Yong Liu, Yang-Xi Tian, Pei-Chao Liu, Zhi-Sheng |
author_sort | Qian, Qiao-Qiao |
collection | PubMed |
description | Background: Tic disorders (TDs), including Tourette syndrome, are childhood-onset neuropsychiatric disorders characterized by motor and/or vocal tics that commonly affect children’s physical and mental health. The pathogenesis of TDs may be related to abnormal neurotransmitters in the cortico-striatal-thalamo-cortical circuitry, especially dopaminergic, glutamatergic, and serotonergic neurotransmitters. The purpose of this study was to preliminarily investigate the differences in the three types of neurotransmitters in plasma and urine between children with TD and healthy children. Methods: We collected 94 samples of plasma and 69 samples of urine from 3–12-year-old Chinese Han children with TD before treatment. The plasma and urine of the same number of healthy Chinese Han children, matched for age and sex, participating in a physical examination, were collected. Ultra-performance liquid chromatography-tandem mass spectrometry was used to detect the three types of neurotransmitters in the above samples. Results: The plasma levels of norepinephrine, glutamic acid, and γ-aminobutyric acid, and the urine levels of normetanephrine and 5-hydroxyindoleacetic acid were higher in the TD children than in healthy children. The area under the curve (AUC) values of the above neurotransmitters in plasma and urine analyzed by receiver operating characteristic curve analysis were all higher than 0.6, with significant differences. Among them, the combined AUC of dopamine, norepinephrine, normetanephrine, glutamic acid, and γ-aminobutyric acid in the 8–12-year-old subgroup was 0.930, and the sensitivity and specificity for TD were 0.821 and 0.974, respectively (p = 0.000). Conclusions: There are differences in plasma and urine neurotransmitters between TD children and healthy children, which lays a foundation for further research on the pathogenesis of TD. |
format | Online Article Text |
id | pubmed-9313232 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93132322022-07-26 A Pilot Study on Plasma and Urine Neurotransmitter Levels in Children with Tic Disorders Qian, Qiao-Qiao Tan, Qian-Qian Sun, Dan Lu, Qing Xin, Ying-Ying Wu, Qian Zhou, Yong Liu, Yang-Xi Tian, Pei-Chao Liu, Zhi-Sheng Brain Sci Article Background: Tic disorders (TDs), including Tourette syndrome, are childhood-onset neuropsychiatric disorders characterized by motor and/or vocal tics that commonly affect children’s physical and mental health. The pathogenesis of TDs may be related to abnormal neurotransmitters in the cortico-striatal-thalamo-cortical circuitry, especially dopaminergic, glutamatergic, and serotonergic neurotransmitters. The purpose of this study was to preliminarily investigate the differences in the three types of neurotransmitters in plasma and urine between children with TD and healthy children. Methods: We collected 94 samples of plasma and 69 samples of urine from 3–12-year-old Chinese Han children with TD before treatment. The plasma and urine of the same number of healthy Chinese Han children, matched for age and sex, participating in a physical examination, were collected. Ultra-performance liquid chromatography-tandem mass spectrometry was used to detect the three types of neurotransmitters in the above samples. Results: The plasma levels of norepinephrine, glutamic acid, and γ-aminobutyric acid, and the urine levels of normetanephrine and 5-hydroxyindoleacetic acid were higher in the TD children than in healthy children. The area under the curve (AUC) values of the above neurotransmitters in plasma and urine analyzed by receiver operating characteristic curve analysis were all higher than 0.6, with significant differences. Among them, the combined AUC of dopamine, norepinephrine, normetanephrine, glutamic acid, and γ-aminobutyric acid in the 8–12-year-old subgroup was 0.930, and the sensitivity and specificity for TD were 0.821 and 0.974, respectively (p = 0.000). Conclusions: There are differences in plasma and urine neurotransmitters between TD children and healthy children, which lays a foundation for further research on the pathogenesis of TD. MDPI 2022-07-04 /pmc/articles/PMC9313232/ /pubmed/35884687 http://dx.doi.org/10.3390/brainsci12070880 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Qian, Qiao-Qiao Tan, Qian-Qian Sun, Dan Lu, Qing Xin, Ying-Ying Wu, Qian Zhou, Yong Liu, Yang-Xi Tian, Pei-Chao Liu, Zhi-Sheng A Pilot Study on Plasma and Urine Neurotransmitter Levels in Children with Tic Disorders |
title | A Pilot Study on Plasma and Urine Neurotransmitter Levels in Children with Tic Disorders |
title_full | A Pilot Study on Plasma and Urine Neurotransmitter Levels in Children with Tic Disorders |
title_fullStr | A Pilot Study on Plasma and Urine Neurotransmitter Levels in Children with Tic Disorders |
title_full_unstemmed | A Pilot Study on Plasma and Urine Neurotransmitter Levels in Children with Tic Disorders |
title_short | A Pilot Study on Plasma and Urine Neurotransmitter Levels in Children with Tic Disorders |
title_sort | pilot study on plasma and urine neurotransmitter levels in children with tic disorders |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313232/ https://www.ncbi.nlm.nih.gov/pubmed/35884687 http://dx.doi.org/10.3390/brainsci12070880 |
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