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No Association of Hair Zinc Concentration with Coronary Artery Disease Severity and No Relation with Acute Coronary Syndromes

Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Although zinc (Zn) was reported to have antioxidant, anti-inflammatory and protective properties in CVDs, its association with coronary artery disease (CAD) is still unclear. As methods commonly used to assess Zn levels in bloo...

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Autores principales: Dziedzic, Ewelina A., Gąsior, Jakub S., Tuzimek, Agnieszka, Paleczny, Justyna, Kwaśny, Mirosław, Dąbrowski, Marek, Jankowski, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313242/
https://www.ncbi.nlm.nih.gov/pubmed/35883417
http://dx.doi.org/10.3390/biom12070862
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author Dziedzic, Ewelina A.
Gąsior, Jakub S.
Tuzimek, Agnieszka
Paleczny, Justyna
Kwaśny, Mirosław
Dąbrowski, Marek
Jankowski, Piotr
author_facet Dziedzic, Ewelina A.
Gąsior, Jakub S.
Tuzimek, Agnieszka
Paleczny, Justyna
Kwaśny, Mirosław
Dąbrowski, Marek
Jankowski, Piotr
author_sort Dziedzic, Ewelina A.
collection PubMed
description Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Although zinc (Zn) was reported to have antioxidant, anti-inflammatory and protective properties in CVDs, its association with coronary artery disease (CAD) is still unclear. As methods commonly used to assess Zn levels in blood and urine do not show the full picture of the microelement supply, in this study, the nutritional status of Zn in patients with angiographically confirmed CAD was assessed using inductively coupled plasma optical emission spectrometry. We found no association between Zn and the severity of CAD evaluated with the Coronary Artery Surgery Study Score (p = 0.67). There were no statistically significant differences in Zn levels between patients with acute coronary syndrome and those with stable CAD (p = 0.937). A statically significant negative correlation was observed between Zn content and serum triglyceride concentration (p < 0.05). Patients with type 2 diabetes mellitus were found to have a significantly lower hair Zn content compared to non-diabetic individuals (p < 0.01). The role of Zn in the pathogenesis of CAD and its complications need further well-designed research as the moderation and supplementation of Zn dietary intake could be a simple intervention to reduce the CVDs risk.
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spelling pubmed-93132422022-07-26 No Association of Hair Zinc Concentration with Coronary Artery Disease Severity and No Relation with Acute Coronary Syndromes Dziedzic, Ewelina A. Gąsior, Jakub S. Tuzimek, Agnieszka Paleczny, Justyna Kwaśny, Mirosław Dąbrowski, Marek Jankowski, Piotr Biomolecules Article Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Although zinc (Zn) was reported to have antioxidant, anti-inflammatory and protective properties in CVDs, its association with coronary artery disease (CAD) is still unclear. As methods commonly used to assess Zn levels in blood and urine do not show the full picture of the microelement supply, in this study, the nutritional status of Zn in patients with angiographically confirmed CAD was assessed using inductively coupled plasma optical emission spectrometry. We found no association between Zn and the severity of CAD evaluated with the Coronary Artery Surgery Study Score (p = 0.67). There were no statistically significant differences in Zn levels between patients with acute coronary syndrome and those with stable CAD (p = 0.937). A statically significant negative correlation was observed between Zn content and serum triglyceride concentration (p < 0.05). Patients with type 2 diabetes mellitus were found to have a significantly lower hair Zn content compared to non-diabetic individuals (p < 0.01). The role of Zn in the pathogenesis of CAD and its complications need further well-designed research as the moderation and supplementation of Zn dietary intake could be a simple intervention to reduce the CVDs risk. MDPI 2022-06-21 /pmc/articles/PMC9313242/ /pubmed/35883417 http://dx.doi.org/10.3390/biom12070862 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dziedzic, Ewelina A.
Gąsior, Jakub S.
Tuzimek, Agnieszka
Paleczny, Justyna
Kwaśny, Mirosław
Dąbrowski, Marek
Jankowski, Piotr
No Association of Hair Zinc Concentration with Coronary Artery Disease Severity and No Relation with Acute Coronary Syndromes
title No Association of Hair Zinc Concentration with Coronary Artery Disease Severity and No Relation with Acute Coronary Syndromes
title_full No Association of Hair Zinc Concentration with Coronary Artery Disease Severity and No Relation with Acute Coronary Syndromes
title_fullStr No Association of Hair Zinc Concentration with Coronary Artery Disease Severity and No Relation with Acute Coronary Syndromes
title_full_unstemmed No Association of Hair Zinc Concentration with Coronary Artery Disease Severity and No Relation with Acute Coronary Syndromes
title_short No Association of Hair Zinc Concentration with Coronary Artery Disease Severity and No Relation with Acute Coronary Syndromes
title_sort no association of hair zinc concentration with coronary artery disease severity and no relation with acute coronary syndromes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313242/
https://www.ncbi.nlm.nih.gov/pubmed/35883417
http://dx.doi.org/10.3390/biom12070862
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