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NMOSD—Diagnostic Dilemmas Leading towards Final Diagnosis
(1) Background: The emergence of white matter lesions in the central nervous system (CNS) can lead to diagnostic dilemmas. They are a common radiological symptom and their patterns may overlap CNS or systemic diseases and provoke underdiagnosis or misdiagnosis. The aim of the study was to assess fac...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313254/ https://www.ncbi.nlm.nih.gov/pubmed/35884693 http://dx.doi.org/10.3390/brainsci12070885 |
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author | Szewczyk, Anna K. Papuć, Ewa Mitosek-Szewczyk, Krystyna Woś, Michał Rejdak, Konrad |
author_facet | Szewczyk, Anna K. Papuć, Ewa Mitosek-Szewczyk, Krystyna Woś, Michał Rejdak, Konrad |
author_sort | Szewczyk, Anna K. |
collection | PubMed |
description | (1) Background: The emergence of white matter lesions in the central nervous system (CNS) can lead to diagnostic dilemmas. They are a common radiological symptom and their patterns may overlap CNS or systemic diseases and provoke underdiagnosis or misdiagnosis. The aim of the study was to assess factors influencing the underdiagnosis of neuromyelitis optica spectrum disorder (NMOSD) as well as to estimate NMOSD epidemiology in Lubelskie voivodeship, Poland. (2) Methods: This retrospective study included 1112 patients, who were made a tentative or an established diagnosis of acute or subacute onset of neurological deficits. The evaluation was based on medical history, neurological examination, laboratory and radiographic results and fulfilment of diagnosis criteria. (3) Results: Up to 1.62 percent of patients diagnosed with white matter lesions and up to 2.2% of the patients previously diagnosed with MS may suffer from NMOSD. The duration of delayed diagnosis is longer for males, despite the earlier age of onset. Seropositive cases for antibodies against aquaporin-4 have worse prognosis for degree of disability. (4) Conclusions: Underdiagnosis or misdiagnosis in NMOSD still remains a problem in clinical practice and has important implications for patients. The incorrect diagnosis is caused by atypical presentation or NMOSD-mimics; however, covariates such as gender, onset and diagnosis age may also have an influence. |
format | Online Article Text |
id | pubmed-9313254 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93132542022-07-26 NMOSD—Diagnostic Dilemmas Leading towards Final Diagnosis Szewczyk, Anna K. Papuć, Ewa Mitosek-Szewczyk, Krystyna Woś, Michał Rejdak, Konrad Brain Sci Article (1) Background: The emergence of white matter lesions in the central nervous system (CNS) can lead to diagnostic dilemmas. They are a common radiological symptom and their patterns may overlap CNS or systemic diseases and provoke underdiagnosis or misdiagnosis. The aim of the study was to assess factors influencing the underdiagnosis of neuromyelitis optica spectrum disorder (NMOSD) as well as to estimate NMOSD epidemiology in Lubelskie voivodeship, Poland. (2) Methods: This retrospective study included 1112 patients, who were made a tentative or an established diagnosis of acute or subacute onset of neurological deficits. The evaluation was based on medical history, neurological examination, laboratory and radiographic results and fulfilment of diagnosis criteria. (3) Results: Up to 1.62 percent of patients diagnosed with white matter lesions and up to 2.2% of the patients previously diagnosed with MS may suffer from NMOSD. The duration of delayed diagnosis is longer for males, despite the earlier age of onset. Seropositive cases for antibodies against aquaporin-4 have worse prognosis for degree of disability. (4) Conclusions: Underdiagnosis or misdiagnosis in NMOSD still remains a problem in clinical practice and has important implications for patients. The incorrect diagnosis is caused by atypical presentation or NMOSD-mimics; however, covariates such as gender, onset and diagnosis age may also have an influence. MDPI 2022-07-06 /pmc/articles/PMC9313254/ /pubmed/35884693 http://dx.doi.org/10.3390/brainsci12070885 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Szewczyk, Anna K. Papuć, Ewa Mitosek-Szewczyk, Krystyna Woś, Michał Rejdak, Konrad NMOSD—Diagnostic Dilemmas Leading towards Final Diagnosis |
title | NMOSD—Diagnostic Dilemmas Leading towards Final Diagnosis |
title_full | NMOSD—Diagnostic Dilemmas Leading towards Final Diagnosis |
title_fullStr | NMOSD—Diagnostic Dilemmas Leading towards Final Diagnosis |
title_full_unstemmed | NMOSD—Diagnostic Dilemmas Leading towards Final Diagnosis |
title_short | NMOSD—Diagnostic Dilemmas Leading towards Final Diagnosis |
title_sort | nmosd—diagnostic dilemmas leading towards final diagnosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313254/ https://www.ncbi.nlm.nih.gov/pubmed/35884693 http://dx.doi.org/10.3390/brainsci12070885 |
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