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Activation and Pharmacological Regulation of Inflammasomes

Inflammasomes are intracellular signaling complexes of the innate immune system, which is part of the response to exogenous pathogens or physiological aberration. The multiprotein complexes mainly consist of sensor proteins, adaptors, and pro-caspase-1. The assembly of the inflammasome upon extracel...

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Detalles Bibliográficos
Autores principales: Chen, Chen, Xu, Pinglong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313256/
https://www.ncbi.nlm.nih.gov/pubmed/35883561
http://dx.doi.org/10.3390/biom12071005
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author Chen, Chen
Xu, Pinglong
author_facet Chen, Chen
Xu, Pinglong
author_sort Chen, Chen
collection PubMed
description Inflammasomes are intracellular signaling complexes of the innate immune system, which is part of the response to exogenous pathogens or physiological aberration. The multiprotein complexes mainly consist of sensor proteins, adaptors, and pro-caspase-1. The assembly of the inflammasome upon extracellular and intracellular cues drives the activation of caspase-1, which processes pro-inflammatory cytokines IL-1β and IL-18 to maturation and gasdermin-D for pore formation, leading to pyroptosis and cytokine release. Inflammasome signaling functions in numerous infectious or sterile inflammatory diseases, including inherited autoinflammatory diseases, metabolic disorders, cardiovascular diseases, cancers, neurodegenerative disorders, and COVID-19. In this review, we summarized current ideas on the organization and activation of inflammasomes, with details on the molecular mechanisms, regulations, and interventions. The recent developments of pharmacological strategies targeting inflammasomes as disease therapeutics were also covered.
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spelling pubmed-93132562022-07-26 Activation and Pharmacological Regulation of Inflammasomes Chen, Chen Xu, Pinglong Biomolecules Review Inflammasomes are intracellular signaling complexes of the innate immune system, which is part of the response to exogenous pathogens or physiological aberration. The multiprotein complexes mainly consist of sensor proteins, adaptors, and pro-caspase-1. The assembly of the inflammasome upon extracellular and intracellular cues drives the activation of caspase-1, which processes pro-inflammatory cytokines IL-1β and IL-18 to maturation and gasdermin-D for pore formation, leading to pyroptosis and cytokine release. Inflammasome signaling functions in numerous infectious or sterile inflammatory diseases, including inherited autoinflammatory diseases, metabolic disorders, cardiovascular diseases, cancers, neurodegenerative disorders, and COVID-19. In this review, we summarized current ideas on the organization and activation of inflammasomes, with details on the molecular mechanisms, regulations, and interventions. The recent developments of pharmacological strategies targeting inflammasomes as disease therapeutics were also covered. MDPI 2022-07-20 /pmc/articles/PMC9313256/ /pubmed/35883561 http://dx.doi.org/10.3390/biom12071005 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chen, Chen
Xu, Pinglong
Activation and Pharmacological Regulation of Inflammasomes
title Activation and Pharmacological Regulation of Inflammasomes
title_full Activation and Pharmacological Regulation of Inflammasomes
title_fullStr Activation and Pharmacological Regulation of Inflammasomes
title_full_unstemmed Activation and Pharmacological Regulation of Inflammasomes
title_short Activation and Pharmacological Regulation of Inflammasomes
title_sort activation and pharmacological regulation of inflammasomes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313256/
https://www.ncbi.nlm.nih.gov/pubmed/35883561
http://dx.doi.org/10.3390/biom12071005
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