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Activation and Pharmacological Regulation of Inflammasomes
Inflammasomes are intracellular signaling complexes of the innate immune system, which is part of the response to exogenous pathogens or physiological aberration. The multiprotein complexes mainly consist of sensor proteins, adaptors, and pro-caspase-1. The assembly of the inflammasome upon extracel...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313256/ https://www.ncbi.nlm.nih.gov/pubmed/35883561 http://dx.doi.org/10.3390/biom12071005 |
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author | Chen, Chen Xu, Pinglong |
author_facet | Chen, Chen Xu, Pinglong |
author_sort | Chen, Chen |
collection | PubMed |
description | Inflammasomes are intracellular signaling complexes of the innate immune system, which is part of the response to exogenous pathogens or physiological aberration. The multiprotein complexes mainly consist of sensor proteins, adaptors, and pro-caspase-1. The assembly of the inflammasome upon extracellular and intracellular cues drives the activation of caspase-1, which processes pro-inflammatory cytokines IL-1β and IL-18 to maturation and gasdermin-D for pore formation, leading to pyroptosis and cytokine release. Inflammasome signaling functions in numerous infectious or sterile inflammatory diseases, including inherited autoinflammatory diseases, metabolic disorders, cardiovascular diseases, cancers, neurodegenerative disorders, and COVID-19. In this review, we summarized current ideas on the organization and activation of inflammasomes, with details on the molecular mechanisms, regulations, and interventions. The recent developments of pharmacological strategies targeting inflammasomes as disease therapeutics were also covered. |
format | Online Article Text |
id | pubmed-9313256 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93132562022-07-26 Activation and Pharmacological Regulation of Inflammasomes Chen, Chen Xu, Pinglong Biomolecules Review Inflammasomes are intracellular signaling complexes of the innate immune system, which is part of the response to exogenous pathogens or physiological aberration. The multiprotein complexes mainly consist of sensor proteins, adaptors, and pro-caspase-1. The assembly of the inflammasome upon extracellular and intracellular cues drives the activation of caspase-1, which processes pro-inflammatory cytokines IL-1β and IL-18 to maturation and gasdermin-D for pore formation, leading to pyroptosis and cytokine release. Inflammasome signaling functions in numerous infectious or sterile inflammatory diseases, including inherited autoinflammatory diseases, metabolic disorders, cardiovascular diseases, cancers, neurodegenerative disorders, and COVID-19. In this review, we summarized current ideas on the organization and activation of inflammasomes, with details on the molecular mechanisms, regulations, and interventions. The recent developments of pharmacological strategies targeting inflammasomes as disease therapeutics were also covered. MDPI 2022-07-20 /pmc/articles/PMC9313256/ /pubmed/35883561 http://dx.doi.org/10.3390/biom12071005 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chen, Chen Xu, Pinglong Activation and Pharmacological Regulation of Inflammasomes |
title | Activation and Pharmacological Regulation of Inflammasomes |
title_full | Activation and Pharmacological Regulation of Inflammasomes |
title_fullStr | Activation and Pharmacological Regulation of Inflammasomes |
title_full_unstemmed | Activation and Pharmacological Regulation of Inflammasomes |
title_short | Activation and Pharmacological Regulation of Inflammasomes |
title_sort | activation and pharmacological regulation of inflammasomes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313256/ https://www.ncbi.nlm.nih.gov/pubmed/35883561 http://dx.doi.org/10.3390/biom12071005 |
work_keys_str_mv | AT chenchen activationandpharmacologicalregulationofinflammasomes AT xupinglong activationandpharmacologicalregulationofinflammasomes |