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APOE ε4 in Depression-Associated Memory Impairment—Evidence from Genetic and MicroRNA Analyses
(1) Background: The aim of this study was to replicate a reported interaction between APOE ε4 status and depression on memory function in two independent, nondemented samples from the general population and to examine the potential role of circulating plasma miRNAs. (2) Methods: The impact of the AP...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313258/ https://www.ncbi.nlm.nih.gov/pubmed/35884866 http://dx.doi.org/10.3390/biomedicines10071560 |
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author | Bonk, Sarah Kirchner, Kevin Ameling, Sabine Garvert, Linda Völzke, Henry Nauck, Matthias Völker, Uwe Grabe, Hans J. Van der Auwera, Sandra |
author_facet | Bonk, Sarah Kirchner, Kevin Ameling, Sabine Garvert, Linda Völzke, Henry Nauck, Matthias Völker, Uwe Grabe, Hans J. Van der Auwera, Sandra |
author_sort | Bonk, Sarah |
collection | PubMed |
description | (1) Background: The aim of this study was to replicate a reported interaction between APOE ε4 status and depression on memory function in two independent, nondemented samples from the general population and to examine the potential role of circulating plasma miRNAs. (2) Methods: The impact of the APOE ε4 allele on verbal memory and the interaction with depression is investigated in two large general-population cohorts from the Study of Health in Pomerania (SHIP, total n = 6286). Additionally, biological insights are gained by examining the potential role of circulating plasma miRNAs as potential epigenetic regulators. Analyses are performed using linear regression models adjusted for relevant biological and environmental covariates. (3) Results: Current depression as well as carrying the APOE ε4 allele were associated with impaired memory performance, with increasing effect for subjects with both risk factors. In a subcohort with available miRNA data subjects with current depressive symptoms and carrying APOE e4 revealed reduced levels of hsa-miR-107, a prominent risk marker for early Alzheimer’s Disease. (4) Conclusions: Our results confirm the effect of depressive symptoms and APOE ε4 status on memory performance. Additionally, miRNA analysis identified hsa-miR-107 as a possible biological link between APOE ε4, depressive symptoms, and cognitive impairment. |
format | Online Article Text |
id | pubmed-9313258 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93132582022-07-26 APOE ε4 in Depression-Associated Memory Impairment—Evidence from Genetic and MicroRNA Analyses Bonk, Sarah Kirchner, Kevin Ameling, Sabine Garvert, Linda Völzke, Henry Nauck, Matthias Völker, Uwe Grabe, Hans J. Van der Auwera, Sandra Biomedicines Article (1) Background: The aim of this study was to replicate a reported interaction between APOE ε4 status and depression on memory function in two independent, nondemented samples from the general population and to examine the potential role of circulating plasma miRNAs. (2) Methods: The impact of the APOE ε4 allele on verbal memory and the interaction with depression is investigated in two large general-population cohorts from the Study of Health in Pomerania (SHIP, total n = 6286). Additionally, biological insights are gained by examining the potential role of circulating plasma miRNAs as potential epigenetic regulators. Analyses are performed using linear regression models adjusted for relevant biological and environmental covariates. (3) Results: Current depression as well as carrying the APOE ε4 allele were associated with impaired memory performance, with increasing effect for subjects with both risk factors. In a subcohort with available miRNA data subjects with current depressive symptoms and carrying APOE e4 revealed reduced levels of hsa-miR-107, a prominent risk marker for early Alzheimer’s Disease. (4) Conclusions: Our results confirm the effect of depressive symptoms and APOE ε4 status on memory performance. Additionally, miRNA analysis identified hsa-miR-107 as a possible biological link between APOE ε4, depressive symptoms, and cognitive impairment. MDPI 2022-06-30 /pmc/articles/PMC9313258/ /pubmed/35884866 http://dx.doi.org/10.3390/biomedicines10071560 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bonk, Sarah Kirchner, Kevin Ameling, Sabine Garvert, Linda Völzke, Henry Nauck, Matthias Völker, Uwe Grabe, Hans J. Van der Auwera, Sandra APOE ε4 in Depression-Associated Memory Impairment—Evidence from Genetic and MicroRNA Analyses |
title | APOE ε4 in Depression-Associated Memory Impairment—Evidence from Genetic and MicroRNA Analyses |
title_full | APOE ε4 in Depression-Associated Memory Impairment—Evidence from Genetic and MicroRNA Analyses |
title_fullStr | APOE ε4 in Depression-Associated Memory Impairment—Evidence from Genetic and MicroRNA Analyses |
title_full_unstemmed | APOE ε4 in Depression-Associated Memory Impairment—Evidence from Genetic and MicroRNA Analyses |
title_short | APOE ε4 in Depression-Associated Memory Impairment—Evidence from Genetic and MicroRNA Analyses |
title_sort | apoe ε4 in depression-associated memory impairment—evidence from genetic and microrna analyses |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313258/ https://www.ncbi.nlm.nih.gov/pubmed/35884866 http://dx.doi.org/10.3390/biomedicines10071560 |
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