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Investigation of the Drug Carrier Properties of Insoluble Cyclodextrin Polymer Microspheres
The investigation of the usability of solid insoluble β-cyclodextrin polymers (βCDP) in micro-sized, controlled drug delivery systems has only recently attracted interest. Our aim was to form complexes with poorly soluble active pharmaceutical ingredients (APIs) with two types of βCDP for drug deliv...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313285/ https://www.ncbi.nlm.nih.gov/pubmed/35883488 http://dx.doi.org/10.3390/biom12070931 |
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author | Haimhoffer, Ádám Vas, Alexandra Árvai, Gabriella Fenyvesi, Éva Jicsinszky, László Budai, István Bényei, Attila Regdon, Géza Rusznyák, Ágnes Vasvári, Gábor Váradi, Judit Bácskay, Ildikó Vecsernyés, Miklós Fenyvesi, Ferenc |
author_facet | Haimhoffer, Ádám Vas, Alexandra Árvai, Gabriella Fenyvesi, Éva Jicsinszky, László Budai, István Bényei, Attila Regdon, Géza Rusznyák, Ágnes Vasvári, Gábor Váradi, Judit Bácskay, Ildikó Vecsernyés, Miklós Fenyvesi, Ferenc |
author_sort | Haimhoffer, Ádám |
collection | PubMed |
description | The investigation of the usability of solid insoluble β-cyclodextrin polymers (βCDP) in micro-sized, controlled drug delivery systems has only recently attracted interest. Our aim was to form complexes with poorly soluble active pharmaceutical ingredients (APIs) with two types of βCDP for drug delivery applications. Solid insoluble cyclodextrin polymer of irregular shape (βCDPIS) and cyclodextrin microbeads (βCDPB) were used in the experiments. Morphology, surface area, size distribution and swelling capacity of carriers were investigated. We created complexes with two APIs, curcumin and estradiol, and applied powder X-ray diffraction, FTIR and thermal analysis (TGA/DSC) to prove the complexation. Finally, the dissolution, biocompatibility and permeation of APIs on Caco-2 cells were investigated. The size of the beads was larger than 100 µm, their shape was spherical and surfaces were smooth; while the βCDPIS particles were around 4 µm with irregular shape and surface. None of the polymers showed any cytotoxic effect on Caco-2 cells. Both carriers were able to extract curcumin and estradiol from aqueous solutions, and the dissolution test showed prolonged estradiol release. Caco-2 permeability tests were in accordance with the complexation abilities and dissolution of the complexes. This study offers useful data for further pharmaceutical applications of insoluble cyclodextrin polymers. |
format | Online Article Text |
id | pubmed-9313285 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93132852022-07-26 Investigation of the Drug Carrier Properties of Insoluble Cyclodextrin Polymer Microspheres Haimhoffer, Ádám Vas, Alexandra Árvai, Gabriella Fenyvesi, Éva Jicsinszky, László Budai, István Bényei, Attila Regdon, Géza Rusznyák, Ágnes Vasvári, Gábor Váradi, Judit Bácskay, Ildikó Vecsernyés, Miklós Fenyvesi, Ferenc Biomolecules Article The investigation of the usability of solid insoluble β-cyclodextrin polymers (βCDP) in micro-sized, controlled drug delivery systems has only recently attracted interest. Our aim was to form complexes with poorly soluble active pharmaceutical ingredients (APIs) with two types of βCDP for drug delivery applications. Solid insoluble cyclodextrin polymer of irregular shape (βCDPIS) and cyclodextrin microbeads (βCDPB) were used in the experiments. Morphology, surface area, size distribution and swelling capacity of carriers were investigated. We created complexes with two APIs, curcumin and estradiol, and applied powder X-ray diffraction, FTIR and thermal analysis (TGA/DSC) to prove the complexation. Finally, the dissolution, biocompatibility and permeation of APIs on Caco-2 cells were investigated. The size of the beads was larger than 100 µm, their shape was spherical and surfaces were smooth; while the βCDPIS particles were around 4 µm with irregular shape and surface. None of the polymers showed any cytotoxic effect on Caco-2 cells. Both carriers were able to extract curcumin and estradiol from aqueous solutions, and the dissolution test showed prolonged estradiol release. Caco-2 permeability tests were in accordance with the complexation abilities and dissolution of the complexes. This study offers useful data for further pharmaceutical applications of insoluble cyclodextrin polymers. MDPI 2022-07-02 /pmc/articles/PMC9313285/ /pubmed/35883488 http://dx.doi.org/10.3390/biom12070931 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Haimhoffer, Ádám Vas, Alexandra Árvai, Gabriella Fenyvesi, Éva Jicsinszky, László Budai, István Bényei, Attila Regdon, Géza Rusznyák, Ágnes Vasvári, Gábor Váradi, Judit Bácskay, Ildikó Vecsernyés, Miklós Fenyvesi, Ferenc Investigation of the Drug Carrier Properties of Insoluble Cyclodextrin Polymer Microspheres |
title | Investigation of the Drug Carrier Properties of Insoluble Cyclodextrin Polymer Microspheres |
title_full | Investigation of the Drug Carrier Properties of Insoluble Cyclodextrin Polymer Microspheres |
title_fullStr | Investigation of the Drug Carrier Properties of Insoluble Cyclodextrin Polymer Microspheres |
title_full_unstemmed | Investigation of the Drug Carrier Properties of Insoluble Cyclodextrin Polymer Microspheres |
title_short | Investigation of the Drug Carrier Properties of Insoluble Cyclodextrin Polymer Microspheres |
title_sort | investigation of the drug carrier properties of insoluble cyclodextrin polymer microspheres |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313285/ https://www.ncbi.nlm.nih.gov/pubmed/35883488 http://dx.doi.org/10.3390/biom12070931 |
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