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The Multifaceted Role of Aquaporin-9 in Health and Its Potential as a Clinical Biomarker
Aquaporins (AQPs) are transmembrane channels essential for water, energy, and redox homeostasis, with proven involvement in a variety of pathophysiological conditions such as edema, glaucoma, nephrogenic diabetes insipidus, oxidative stress, sepsis, cancer, and metabolic dysfunctions. The 13 AQPs pr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313442/ https://www.ncbi.nlm.nih.gov/pubmed/35883453 http://dx.doi.org/10.3390/biom12070897 |
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author | da Silva, Inês V. Garra, Sabino Calamita, Giuseppe Soveral, Graça |
author_facet | da Silva, Inês V. Garra, Sabino Calamita, Giuseppe Soveral, Graça |
author_sort | da Silva, Inês V. |
collection | PubMed |
description | Aquaporins (AQPs) are transmembrane channels essential for water, energy, and redox homeostasis, with proven involvement in a variety of pathophysiological conditions such as edema, glaucoma, nephrogenic diabetes insipidus, oxidative stress, sepsis, cancer, and metabolic dysfunctions. The 13 AQPs present in humans are widely distributed in all body districts, drawing cell lineage-specific expression patterns closely related to cell native functions. Compelling evidence indicates that AQPs are proteins with great potential as biomarkers and targets for therapeutic intervention. Aquaporin-9 (AQP9) is the most expressed in the liver, with implications in general metabolic and redox balance due to its aquaglyceroporin and peroxiporin activities, facilitating glycerol and hydrogen peroxide (H(2)O(2)) diffusion across membranes. AQP9 is also expressed in other tissues, and their altered expression is described in several human diseases, such as liver injury, inflammation, cancer, infertility, and immune disorders. The present review compiles the current knowledge of AQP9 implication in diseases and highlights its potential as a new biomarker for diagnosis and prognosis in clinical medicine. |
format | Online Article Text |
id | pubmed-9313442 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93134422022-07-26 The Multifaceted Role of Aquaporin-9 in Health and Its Potential as a Clinical Biomarker da Silva, Inês V. Garra, Sabino Calamita, Giuseppe Soveral, Graça Biomolecules Review Aquaporins (AQPs) are transmembrane channels essential for water, energy, and redox homeostasis, with proven involvement in a variety of pathophysiological conditions such as edema, glaucoma, nephrogenic diabetes insipidus, oxidative stress, sepsis, cancer, and metabolic dysfunctions. The 13 AQPs present in humans are widely distributed in all body districts, drawing cell lineage-specific expression patterns closely related to cell native functions. Compelling evidence indicates that AQPs are proteins with great potential as biomarkers and targets for therapeutic intervention. Aquaporin-9 (AQP9) is the most expressed in the liver, with implications in general metabolic and redox balance due to its aquaglyceroporin and peroxiporin activities, facilitating glycerol and hydrogen peroxide (H(2)O(2)) diffusion across membranes. AQP9 is also expressed in other tissues, and their altered expression is described in several human diseases, such as liver injury, inflammation, cancer, infertility, and immune disorders. The present review compiles the current knowledge of AQP9 implication in diseases and highlights its potential as a new biomarker for diagnosis and prognosis in clinical medicine. MDPI 2022-06-27 /pmc/articles/PMC9313442/ /pubmed/35883453 http://dx.doi.org/10.3390/biom12070897 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review da Silva, Inês V. Garra, Sabino Calamita, Giuseppe Soveral, Graça The Multifaceted Role of Aquaporin-9 in Health and Its Potential as a Clinical Biomarker |
title | The Multifaceted Role of Aquaporin-9 in Health and Its Potential as a Clinical Biomarker |
title_full | The Multifaceted Role of Aquaporin-9 in Health and Its Potential as a Clinical Biomarker |
title_fullStr | The Multifaceted Role of Aquaporin-9 in Health and Its Potential as a Clinical Biomarker |
title_full_unstemmed | The Multifaceted Role of Aquaporin-9 in Health and Its Potential as a Clinical Biomarker |
title_short | The Multifaceted Role of Aquaporin-9 in Health and Its Potential as a Clinical Biomarker |
title_sort | multifaceted role of aquaporin-9 in health and its potential as a clinical biomarker |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313442/ https://www.ncbi.nlm.nih.gov/pubmed/35883453 http://dx.doi.org/10.3390/biom12070897 |
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